Is there hope for preventing or slowing the progression of chronic renal disease? More support for the role of growth factors

2001 ◽  
Vol 38 (3) ◽  
pp. 652-654
Author(s):  
Errol D. Crook
Keyword(s):  
Growth Factors ◽  
Renal Disease ◽  
Chronic Renal Disease

scholarly journals Evolving role of growth factors in the renal response to acute and chronic disease.

1992 ◽  
Vol 2 (7) ◽  
pp. 1163-1170
Author(s):  
L G Fine ◽  
M R Hammerman ◽  
H E Abboud
Keyword(s):  
Growth Factors ◽  
Growth Factor ◽  
Renal Disease ◽  
Egf Receptor ◽  
Chronic Renal Disease ◽  
Collecting Duct ◽  
Platelet Derived Growth Factor ◽  
Glomerular Mesangial Cells ◽  
Hypertrophic Growth

The roles of growth factors in the pathogenesis of various forms of acute and chronic renal disease are largely putative. Nevertheless, there is a growing body of information that links specific growth factors to particular forms of renal injury. In all instances, it is supposed that such associations are not necessarily unique and that multiple cytokines probably interact to determine the pattern of injury or the regenerative response to such injury. Regeneration of tubular epithelium after acute tubular necrosis involves upregulation of the epidermal growth factor (EGF) receptor. Early studies of exogenously administered EGF indicate that the severity and duration of renal failure may be attenuated by this growth factor. Thus far, the observed responses have been limited and the role of EGF as a therapeutic agent requires more study. The mechanism of generation of tubulointerstitial injury in most forms of renal disease is difficult to understand. Early in vitro studies of growth factor production by tubular cells (in the absence of any infiltrating cells) indicate that platelet-derived growth factor produced by the medullary collecting duct is mitogenic for renal medullary fibroblasts, suggesting a paracrine growth system in this region of the kidney. Insulin-like growth factor I has also been shown to be produced by collecting duct cells. Its production is increased by EGF, and its association with certain forms of renal hypertrophy, i.e., diabetes and hypersomatotrophic states, implies its participation in the hypertrophic growth response. Platelet-derived growth factor is a potent mitogen for glomerular mesangial cells, and its production is regulated by a variety of cytokines.(ABSTRACT TRUNCATED AT 250 WORDS)

Role of the Renin-Angiotensin-Aldosterone System in the Regulation of Plasma Potassium in Chronic Renal Disease

Nephron ◽  
1975 ◽  
Vol 15 (1) ◽  
pp. 35-49 ◽  
Author(s):  
P. Weidmann ◽  
M.H. Maxwell ◽  
P. Rowe ◽  
R. Winer ◽  
S.G. Massry
Keyword(s):  
Renal Disease ◽  
Chronic Renal Disease ◽  
Plasma Potassium ◽  
Renin Angiotensin Aldosterone System ◽  
Renin Angiotensin

Role of Renal Prostaglandin E2 in Chronic Renal Disease Hypertension

Nephron ◽  
1982 ◽  
Vol 32 (3) ◽  
pp. 202-206 ◽  
Author(s):  
L. Ruilope ◽  
Garcia Robles ◽  
C. Bernis ◽  
A. Barrientos ◽  
J. Alcazar ◽  
...  
Keyword(s):  
Renal Disease ◽  
Chronic Renal Disease ◽  
Prostaglandin E

scholarly journals Role of dietary factors in the progression of chronic renal disease

1983 ◽  
Vol 24 (5) ◽  
pp. 579-587 ◽  
Author(s):  
Saulo Klahr ◽  
John Buerkert ◽  
Mabel L. Purkerson
Keyword(s):  
Renal Disease ◽  
Chronic Renal Disease ◽  
Dietary Factors

ROLE OF HAEMODIALYSIS AND HEPATITIS C VIRUS INFECTION IN SPONTANEOUS AND INDUCED CYTOKINE PRODUCTION OF PATIENTS WITH CHRONIC RENAL DISEASE

Cytokine ◽  
2000 ◽  
Vol 12 (8) ◽  
pp. 1248-1252 ◽  
Author(s):  
Julio Martı́n ◽  
Patricia de Sequera ◽  
Juan Antonio Quiroga ◽  
Miguel Rico ◽  
Mario Fernández ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Virus Infection ◽  
Renal Disease ◽  
Cytokine Production ◽  
Chronic Renal Disease ◽  
Hepatitis C Virus Infection
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