E-cadherin expression in pleomorphic lobular carcinoma: An aid to differentiation from ductal carcinoma

2002 ◽  
Vol 6 (6) ◽  
pp. 349-351 ◽  
Author(s):  
Amer Wahed ◽  
John Connelly ◽  
Tommy Reese
Keyword(s):  
Ductal Carcinoma ◽  
Lobular Carcinoma ◽  
Pleomorphic Lobular Carcinoma ◽  
E Cadherin

Lobular Neoplasia of the Breast: An Update

2009 ◽  
Vol 133 (7) ◽  
pp. 1116-1120 ◽  
Author(s):  
Alejandro Contreras ◽  
Husain Sattar
Keyword(s):  
Carcinoma In Situ ◽  
Ductal Carcinoma ◽  
Lobular Carcinoma ◽  
Lobular Neoplasia ◽  
Therapeutic Interventions ◽  
High Grade ◽  
Lobular Carcinoma In Situ ◽  
Molecular Studies ◽  
Pleomorphic Lobular Carcinoma

Abstract Context.—Lobular neoplasias (LNs) of the breast include atypical lobular neoplasia and lobular carcinoma in situ. Recent evidence suggests that LN is not only a risk factor for invasive lobular carcinoma, but is also a nonobligate precursor. Pleomorphic lobular carcinoma in situ (PLCIS) is a subtype of LN that has high-grade nuclei and other features that may mimic high-grade ductal carcinoma in situ. The management and follow-up of patients diagnosed with LN on core biopsy is a current issue of debate. However, recent genomic and molecular studies have identified candidate genes that may be important in understanding the pathogenesis of atypical lobular neoplasia and lobular carcinoma in situ, and thus may lead to other therapeutic interventions. Objective.—To review the literature on LN of the breast and discuss current issues in the diagnosis and management of this entity, with particular attention to the relatively newly recognized lesion PLCIS. Because the management of PLCIS varies from the other LN lesions, the recognition of PLCIS by the pathologist is necessary. Current issues in the molecular pathogenesis of LN are also presented. Data Sources.—Extensive review of the literature. Hematoxylin-eosin–stained and immunohistochemical-stained tissue from the author's personal collection. Conclusions.—Although morphology and immunohistochemical stains, such as E-cadherin, are important in the diagnosis and understanding of LN, genomic and molecular studies may guide the way these lesions are handled in the future. Recognizing PLCIS is important both for patient management and for our future understanding of LN pathogenesis.

Pleomorphic lobular carcinoma in situ: A distinct entity of controversial significance.

2012 ◽  
Vol 30 (27_suppl) ◽  
pp. 177-177
Author(s):  
Marina De Brot ◽  
Shirin Muhsen ◽  
Victor P. Andrade ◽  
Starr Koslow Mautner ◽  
Melissa Murray ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Carcinoma In Situ ◽  
Ductal Carcinoma ◽  
Lobular Carcinoma ◽  
Previous History ◽  
Prior History ◽  
Lobular Carcinoma In Situ ◽  
Pleomorphic Lobular Carcinoma ◽  
History Of

177 Background: Pleomorphic lobular carcinoma in situ (PLCIS) is an increasingly diagnosed variant of lobular carcinoma in situ. Histologically, it resembles ductal carcinoma in situ (DCIS), leading to controversy over proper management. Yet, the natural history of PLCIS is unknown. Here we describe our experience with PLCIS. Methods: Review of pathology reports (1995–2012) identified 233 cases of LCIS variants. Patients with synchronous ipsilateral DCIS or invasive cancer (IC) were excluded leaving 25 cases for review. Consensus review by 3 pathologists further excluded 7; leaving 18 cases, 12 of which were classified as PLCIS and 6 as LCIS with pleomorphic features (LCIS-PF). (Table) PLCIS was defined by cellular dyshesion, nuclear pleomorphism with a 2-3 fold size variation, conspicuous nucleoli, mitoses and abundant cytoplasm; lesions not meeting all parameters were classified as LCIS-PF. Loss of e-cadherin was confirmed; clinical data were obtained from medical records. Results: Mean patient age at diagnosis of PLCIS/LCIS-PF was 57 yrs (42-67 yrs). All cases presented with imaging abnormalities. A previous history of breast cancer was present in 7/18 (39%) pts (3/7, ipsilateral; 4/7, contralateral). Following PLCIS/LCIS-PF diagnosis, 6/18 (33%) pts underwent mastectomy and 12/18 had excision alone, with (n=3) or without chemoprevention (n=9). Margin status was negative in 4/12 pts; close in 3/12 pts and positive in 5/12 pts undergoing excision. At a median follow-up of 27 mos (2-148 mos), 2/12 pts treated with excision developed ipsilateral breast cancer (1 DCIS; 1 IC). Both had close margins at initial excision; median time to cancer, 54 mos. Conclusions: Pure PLCIS is an uncommon lesion. Synchronous malignancy or prior history of breast cancer are often present in patients with PLCIS, contributing to the difficulty in determining the actual risk conferred by this lesion and appropriate management. Efforts to systematically characterize LCIS variants and prospective documentation of outcomes are needed to clarify the significance of these lesions. [Table: see text]

scholarly journals Pleomorphic Lobular Carcinoma in a Male Breast: A Rare Occurrence

2010 ◽  
Vol 2010 ◽  
pp. 1-3 ◽  
Author(s):  
Bhatia Rohini ◽  
P. A. Singh ◽  
Misra Vatsala ◽  
Dhingra Vishal ◽  
Singhal Mitali ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Ductal Carcinoma ◽  
Single Case ◽  
Lobular Carcinoma ◽  
Male Breast ◽  
Classical Type ◽  
Histological Subtypes ◽  
Infiltrating Ductal Carcinoma ◽  
Pleomorphic Lobular Carcinoma

Carcinoma of male breast is uncommon as it accounts for 0.7% of total breast cancer. The pathology of male breast cancer is remarkably similar to that of cancers seen in women. The same histological subtypes of invasive cancer are present, although papillary carcinomas (both invasive and in situ) are more common and lobular carcinomas are less common. The predominant histological type, in males, as in females, reported in large series has been infiltrating ductal carcinoma with scattered reports of infiltrating lobular carcinoma, all of them of classical type except for a single case of pleomorphic infiltrating lobular carcinoma. Herein, we describe a case of pleomorphic lobular carcinoma occurring in male breast.

Pleomorphic Lobular Carcinoma of the Breast: A Morphologically and Clinically Distinct Variant of Lobular Carcinoma

2013 ◽  
Vol 137 (11) ◽  
pp. 1688-1692 ◽  
Author(s):  
Dawn Butler ◽  
Marilin Rosa
Keyword(s):  
Protein Function ◽  
Patient Survival ◽  
Ductal Carcinoma ◽  
Lobular Carcinoma ◽  
Genetic Alterations ◽  
Chromosome Band ◽  
Carcinoma Of The Breast ◽  
Molecular Alterations ◽  
Pleomorphic Lobular Carcinoma ◽  
Breast Malignancies

Pleomorphic lobular carcinoma is an uncommon variant of lobular carcinoma, characterized by significant cytologic atypia that contrasts with the low pleomorphism of classical lobular carcinoma. It accounts for approximately 1% of all epithelial breast malignancies. In addition to its pleomorphism, it is characterized by aggressive behavior and shortened patient survival. Although the morphologic features of pleomorphic lobular carcinoma are well described, it often eludes accurate pathologic characterization. Some controversy surrounds the pathogenesis of pleomorphic lobular carcinoma; however, it is now considered a well-defined variant of invasive lobular carcinoma. Pleomorphic lobular carcinoma shares molecular alterations with classical lobular carcinoma, such as alterations in the gene CDH1 on chromosome band 16q22 that results in changes in E-cadherin protein function. The aggressive biology of pleomorphic lobular carcinoma relates to the acquisition of genetic alterations typical of high-grade ductal carcinoma, such as overexpression of HER2/neu and c-myc.

scholarly journals Frequent E-cadherin Gene Inactivation by Loss of Heterozygosity in Pleomorphic Lobular Carcinoma of the Breast

2003 ◽  
Vol 16 (7) ◽  
pp. 674-678 ◽  
Author(s):  
José Palacios ◽  
David Sarrió ◽  
María C García-Macias ◽  
Bonita Bryant ◽  
Mark E Sobel ◽  
...  
Keyword(s):  
Loss Of Heterozygosity ◽  
Lobular Carcinoma ◽  
Gene Inactivation ◽  
Carcinoma Of The Breast ◽  
Pleomorphic Lobular Carcinoma ◽  
E Cadherin

The Spectrum of Morphomolecular Abnormalities of the E-Cadherin/Catenin Complex in Pleomorphic Lobular Carcinoma of the Breast

2007 ◽  
Vol 15 (3) ◽  
pp. 260-266 ◽  
Author(s):  
David J. Dabbs ◽  
Malathy Kaplai ◽  
Mamatha Chivukula ◽  
Anisa Kanbour ◽  
Amal Kanbour-Shakir ◽  
...  
Keyword(s):  
Lobular Carcinoma ◽  
Carcinoma Of The Breast ◽  
Pleomorphic Lobular Carcinoma ◽  
E Cadherin
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