scholarly journals Effect of different levels and sources of zinc supplementation on quantitative and qualitative semen attributes and serum testosterone level in crossbred cattle (Bos indicus×Bos taurus) bulls

2006 ◽  
Vol 46 (6) ◽  
pp. 663-675 ◽  
Author(s):  
Nishant Kumar ◽  
Ramesh Prashad Verma ◽  
Lallan Prasad Singh ◽  
Vijay Prakash Varshney ◽  
Ram Sharan Dass
Keyword(s):  
Testosterone Level ◽  
Zinc Supplementation ◽  
Bos Taurus ◽  
Bos Indicus ◽  
Serum Testosterone ◽  
Serum Testosterone Level ◽  
Crossbred Cattle ◽  
Different Levels

Effect of zinc supplementation on serum testosterone level in adult male sickle cell anemia subjects

1981 ◽  
Vol 10 (2) ◽  
pp. 119-127 ◽  
Author(s):  
Ananda S. Prasad ◽  
Ali A. Abbasi ◽  
Parviz Rabbani ◽  
Elizabeth Dumouchelle
Keyword(s):  
Sickle Cell ◽  
Adult Male ◽  
Sickle Cell Anemia ◽  
Testosterone Level ◽  
Zinc Supplementation ◽  
Serum Testosterone ◽  
Serum Testosterone Level

scholarly journals Genetically determined serum testosterone level and Covid-19 illness level: A mendelian randomization study

2021 ◽  
Author(s):  
Juan Xiong ◽  
Ziyong Ma ◽  
Ruicheng Miao ◽  
Jie Huang ◽  
Xue-Jun Kong ◽  
...  
Keyword(s):  
Critical Illness ◽  
Testosterone Level ◽  
Mendelian Randomization ◽  
Case Fatality ◽  
Serum Testosterone ◽  
Serum Testosterone Level ◽  
Genome Wide ◽  
Genetically Determined ◽  
Different Levels

Background: It is hypothesized that different levels of hormones especially serum testosterone level could explain the sex differences between men and women on the susceptibility and case fatality rate of COVID-19. However, traditional observational studies that support this hypothesis could not effectively establish the causal effects. Objective: Utilizing recently published genome-wide associations studies (GWAS) on serum Testosterone level and on COVID-19 related phenotypes, we sought to assess the causality through Mendelian Randomization (MR) analyses. We further applied a suite of statistical genomics methods to further explore the biological mechanisms. Results: We found that testosterone level is significantly associated with Covid-19 critical illness. All six MR methods yielded significant associations. There is no significant association between Testosterone and COVID-19 respiratory failure or COVID-19 susceptibility. Conclusion: Based on the GWAS currently available, we provide support for a causal role of Testosterone on COVID-19 critical illness. Nevertheless, we recognize that the COVID-19 susceptibility GWAS effort is still ongoing and there is no such strong locus as CCR5 for HIV discovered for COVID-19.

scholarly journals Effects of exogenous adiponectin supplementation in early pregnant PCOS mice on the metabolic syndrome of adult female offspring

2021 ◽  
Vol 14 (1) ◽  
Author(s):  
Meng Zuo ◽  
Guotao Liao ◽  
Wenqian Zhang ◽  
Dan Xu ◽  
Juan Lu ◽  
...  
Keyword(s):  
Adult Female ◽  
Early Pregnancy ◽  
Testosterone Level ◽  
Metabolic Disorders ◽  
Serum Testosterone ◽  
Female Offspring ◽  
Metabolic Phenotype ◽  
Serum Testosterone Level ◽  
The Metabolic Syndrome ◽  
Pcos Group

Abstract Objective PCOS is a heterogeneous endocrine disorder with both reproductive and metabolic abnormalities. At present, PCOS has been confirmed to have a certain genetic background. Compared with healthy women, the vast majority of PCOS patients have hyperandrogenemia, and this excessive androgen exposure during pregnancy may affect the development of female fetuses. The aim of the current study was to investigate the effect of adiponectin intervention during early pregnancy of obese mice with PCOS on the metabolic phenotype of adult female offspring. Methods After the PCOS model was established, C57BL/6J mice were divided into maternal-control, maternal-PCOS, and maternal-PCOS + APN groups. DHEA-induced PCOS mice were supplemented with adiponectin (10 mg/kg/day) in the early pregnancy in order to eliminate adverse hormone exposure and then traced for endocrine indicators in their adult female offspring, which were observed for metabolism syndrome or endocrine disturbance and exhibited the main effects of APN. To further explore the underlying mechanism, the relative expressions of phosphorylated AMPK, PI3K, and Akt were detected in the ovaries of offspring mice. Results The serum testosterone level of the maternal-PCOS + APN group in early pregnancy was significantly lower than that of the maternal-PCOS group (p < 0.01). The serum testosterone level in the offspring-PCOS + APN group was significantly lower than in the offspring-PCOS group (p <0.05), the diestrus time characterized by massive granulocyte aggregation in the estrus cycle was significantly shorter than in the offspring-PCOS group (p<0.05), and the phenotypes of PCOS-like reproductive disorders and metabolic disorders, such as obesity, insulin resistance, impaired glucose tolerance, and hyperlipidemia, were also significantly improved in the offspring-PCOS + APN group (p < 0.05). Compared with the control group, the expression levels of phosphorylated AMPK, PI3K, and Akt in the offspring-PCOS group were significantly decreased (p < 0.05), while those in the offspring-PCOS + APN group were significantly increased (p < 0.05). Conclusions APN intervention in early pregnancy significantly reduced the adverse effects of maternal obesity and high androgen levels during pregnancy on female offspring and corrected the PCOS-like endocrine phenotype and metabolic disorders of adult female offspring. This effect may be caused by the activation of the AMPK/PI3K-Akt signaling pathway in PCOS offspring mice.

Correlation Between Serum Testosterone Level and Concentrations of Copper and Zinc in Hair Tissue

2011 ◽  
Vol 144 (1-3) ◽  
pp. 264-271 ◽  
Author(s):  
Chung Soo Chang ◽  
Jong Bo Choi ◽  
Hae Jin Kim ◽  
Sat Byul Park
Keyword(s):  
Testosterone Level ◽  
Serum Testosterone ◽  
Serum Testosterone Level ◽  
Copper And Zinc

Vitamin C ameliorates the adverse effects of dexamethasone on sperm motility, testosterone level, and spermatogenesis indexes in mice

2018 ◽  
Vol 38 (4) ◽  
pp. 409-418 ◽  
Author(s):  
F Sadeghzadeh ◽  
MS Mehranjani ◽  
M Mahmoodi
Keyword(s):  
Adverse Effects ◽  
Vitamin C ◽  
Sperm Motility ◽  
Testosterone Level ◽  
Leydig Cells ◽  
Serum Testosterone ◽  
Serum Testosterone Level ◽  
Control Group ◽  
The Mean ◽  
Vit C

Background: Dexamethasone (DEX) is a common medicine that is capable of causing malformation in the male reproductive system. The aim of this study was to investigate the effect of vitamin C (Vit-C) on spermatogenesis indexes and daily sperm production (DSP) in adult mice treated with DEX. Methods: Male Naval Medical Research Institute (NMRI) mice were divided into four groups: Control, DEX (7 mg/kg/day), Vit-C (100 mg/kg/day), and DEX +Vit-C and treated for 7 days with intraperitoneal injection. Results: A significant increase in the mean levels of serum and tissue malondialdehyde (MDA) and apoptosis of Leydig cells was found in the DEX group compared to the control group. Sperm motility, DSP, tubular differentiation index, meiotic index, spermatogenesis index, the mean number of spermatocytes, round and long spermatids, and Leydig cells, and also serum testosterone level decreased in the DEX group compared to the control group. The results of this study indicate that Vit-C can significantly prevent the adverse effects of DEX on the mean number of spermatocyte, spermatid, and Leydig cells, tubular differentiation, meiotic and spermatogenesis index, DSP, sperm motility, and the mean levels of serum MDA. Conclusion: In conclusion, our results showed that coadministration of Vit-C and DEX prevents the adverse effects of DEX on the spermatogenesis indexes and DSP.

Sign in / Sign up

Export Citation Format

Share Document