scholarly journals Although it is rapidly metabolized in cultured rat hepatocytes, lauric acid is used for protein acylation

2003 ◽  
Vol 43 (5) ◽  
pp. 419-430 ◽  
Author(s):  
Vincent Rioux ◽  
Stéphanie Daval ◽  
Hervé Guillou ◽  
Sophie Jan ◽  
Philippe Legrand
Keyword(s):  
Lauric Acid ◽  
Rat Hepatocytes ◽  
Cultured Rat Hepatocytes ◽  
Protein Acylation

scholarly journals The acylation of proteins by xenobiotic amphipathic carboxylic acids in cultured rat hepatocytes

1988 ◽  
Vol 254 (1) ◽  
pp. 39-44 ◽  
Author(s):  
R Hertz ◽  
J Bar−Tana
Keyword(s):  
Protein Synthesis ◽  
Carboxylic Acids ◽  
Mode Of Action ◽  
Biological Effects ◽  
Rat Hepatocytes ◽  
Protein Adducts ◽  
Cultured Rat Hepatocytes ◽  
Acylated Proteins ◽  
Dose Dependent ◽  
Protein Acylation

Three xenobiotic amphipathic carboxylates, namely MEDICA 16, nafenopin and bezafibrate, which differ remarkably in their hydrophobic backbones, were found to acylate membrane and cytosolic liver proteins in cultured rat hepatocytes. The acylation patterns observed were time- and dose-dependent, and the acylated residue consisted of the original xenobiotic. The acylation patterns generated by the three xenobiotic carboxylates included common proteins which were acylated by the three xenobiotics (e.g. proteins of 32, 52, 56 and 72 kDa) as well as unique proteins which were specifically acylated by the respective xenobiotics. The acylation of liver proteins by either MEDICA 16 or nafenopin remained unaffected under conditions where protein synthesis was completely inhibited by cycloheximide. Protein acylation thus offers a common mode of action of xenobiotic amphipathic carboxylates, which may, however, result in diverse xenobiotyl-protein adducts. The xenobiotyl-acylated proteins might be involved in triggering some of the biological effects exerted by xenobiotic amphipathic carboxylates employed as hypolipidaemic effectors, peroxisomal proliferators or preadipocyte convertors.

Nutrition and somatomedin. XXVI. Molecular regulation of IGF-I by insulin in cultured rat hepatocytes

Diabetes ◽  
1991 ◽  
Vol 40 (11) ◽  
pp. 1525-1530 ◽  
Author(s):  
L. S. Phillips ◽  
S. Goldstein ◽  
C. I. Pao
Keyword(s):  
Rat Hepatocytes ◽  
Molecular Regulation ◽  
Igf I ◽  
Cultured Rat Hepatocytes
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