scholarly journals Numerical Modeling of The Quorum Sensing In a Bacterial Biofilm

2018 ◽  
Vol 62 ◽  
pp. 17-29
Author(s):  
A. Blouza ◽  
L. El Alaoui
Keyword(s):  
Quorum Sensing ◽  
Pathogenic Bacteria ◽  
Reaction Diffusion ◽  
Euler Method ◽  
Bacterial Biofilm ◽  
Finite Element Scheme ◽  
Quorum Sensing Inhibitors ◽  
Reaction Diffusion Model ◽  
Linear Reaction ◽  
Uniqueness Of A Solution

In the present paper we propose a bi-dimensional non-linear reaction-diffusion model de-scribing the action of antibiotics as well as quorum sensing inhibitors agents on the virulence of bacteria biofilms. We thus approximate the system by a standard finite element scheme in space and an implicit Euler method in time. We prove the existence and uniqueness of a solution to this system and prove its convergence to a weak solution of the model we introduce. We present numerical results for simulating the quorum sensing of the very human pathogenic bacteria Pseudomenas aeruginosa.

scholarly journals Numerical solution of a coupled reaction-diffusion model using barycentric interpolation collocation method

2020 ◽  
Vol 24 (4) ◽  
pp. 2561-2567
Author(s):  
Yu Zhang ◽  
Wei Zhang ◽  
Chenhui Zhao ◽  
Yulan Wang
Keyword(s):  
Approximate Solution ◽  
Numerical Solution ◽  
Collocation Method ◽  
Diffusion Model ◽  
Numerical Experiments ◽  
Reaction Diffusion ◽  
Barycentric Interpolation ◽  
Reaction Diffusion Model ◽  
Linear Reaction ◽  
Coupled Reaction

In thermal science, chemical and mechanics, the non-linear reaction-diffusion model is very important, and an approximate solution with high precision is always needed. In this article, the barycentric interpolation collocation method is proposed for this purpose. Numerical experiments show that the proposed approach is highly reliable.

Quorum sensing of pathogenic bacteria and quorum-sensing inhibitors

2012 ◽  
Vol 57 (21) ◽  
pp. 1964-1977 ◽  
Author(s):  
ZongHui YUAN ◽  
ZhenLi LIU ◽  
MengHong DAI ◽  
HaiHong HAO ◽  
GuYue CHENG
Keyword(s):  
Quorum Sensing ◽  
Pathogenic Bacteria ◽  
Quorum Sensing Inhibitors

scholarly journals Reduction of exoprotease production in Aeromonas hydrophila by tomato fruits extract (Lycopersicon esculentum Mill.)

2006 ◽  
Vol 4 (2) ◽  
pp. 55-64
Author(s):  
NUR AINI ◽  
SUTARNO SUTARNO ◽  
ARI SUSILOWATI
Keyword(s):  
Quorum Sensing ◽  
Ethyl Acetate ◽  
Aeromonas Hydrophila ◽  
Pathogenic Bacteria ◽  
Methanol Extract ◽  
Signal Molecule ◽  
Tomato Fruits ◽  
Sensing System ◽  
Quorum Sensing Inhibitors ◽  
Assay Result

Aeromonas hydrophila is pathogenic bacteria in fish. One of its virulence factors is exoprotease. The production of exoprotease is controlled by a quorum sensing system. Quorum sensing is an intercellular communication of bacteria that using a signal molecule of C4-HSL. The exoprotease production of A. hydrophila can be blocked by using quorum sensing inhibitors. The inhibition of quorum sensing of A. hydrophila can be conducted by C4-HSL analogs molecules. In this research, the molecules that predicted as quorum sensing inhibitors and act as C4-HSL analog molecules were furanone from tomato fruits. The inhibition of quorum sensing of A. hydrophila could be shown by a reduction of exoprotease production. The aim of this research was to determine the reduction of exoprotease production of A. hydrophila by extracts of n-hexane, ethyl acetate and methanol of tomato fruits with the concentrations of 0%, 2%, 4%, 6% and 8%, respectively. The qualitative exoprotease assay result showed that n-hexane extract of tomato had no effect on growth and exoprotease production of A. hydrophila. As much as 4% of ethyl acetate extract of tomato fruits could inhibit exoprotease production, but affect A. hydrophilla growth. Meanwhile, 4% methanol extract of tomato fruits could inhibit exoprotease production, without affect A. hydrophilla growth. The quantitative exoprotease assay result showed that 4% of methanol extract could inhibit exoprotease production by 71.68% without affect the growth of A. hydrophila.

Influence of Polyphenols on Bacterial Biofilm Formation and Quorum-sensing

2003 ◽  
Vol 58 (11-12) ◽  
pp. 879-884 ◽  
Author(s):  
Birgit Huber ◽  
Leo Eberl ◽  
Walter Feucht ◽  
Jürgen Polster
Keyword(s):  
Gene Regulation ◽  
Quorum Sensing ◽  
Biofilm Formation ◽  
Pathogenic Bacteria ◽  
Bacterial Biofilm ◽  
Signal Molecules ◽  
Bacterial Cells ◽  
Regulatory Systems ◽  
Bacterial Quorum Sensing ◽  
Bacterial Quorum

Abstract Many bacteria utilize sophisticated regulatory systems to ensure that some functions are only expressed when a particular population density has been reached. The term ‘quorumsensing’ has been coined to describe this form of density-dependent gene regulation which relies on the production and perception of small signal molecules by bacterial cells. As in many pathogenic bacteria the production of virulence factors is quorum-sensing regulated, it has been suggested that this form of gene regulation allows the bacteria to remain invisible to the defence systems of the host until the population is sufficiently large to successfully establish the infection. Here we present first evidence that polyphenolic compounds can interfere with bacterial quorum-sensing. Since polyphenols are widely distributed in the plant kingdom, they may be important for promoting plant fitness.

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