QUASI-MOLECULAR EFFECTS IN ION-ATOM COLLISIONS AT ION ENERGIES IN THE HUNDRED-keV REGION

1979 ◽  
Vol 40 (C1) ◽  
pp. C1-246-C1-249
Author(s):  
E. G. Bøving ◽  
K. Edlund ◽  
G. Sørensen
Keyword(s):  
Ion Energies ◽  
Molecular Effects

The cellular and molecular effects of the androgen receptor agonist, Cl-4AS-1, on breast cancer cells

2016 ◽  
Author(s):  
Mamoun Ahram ◽  
Ebtihal Mustafa ◽  
Shatha Abu Hammad ◽  
Mariam Hodhod ◽  
Malek Zihlif
Keyword(s):  
Breast Cancer ◽  
Androgen Receptor ◽  
Cancer Cells ◽  
Receptor Agonist ◽  
Breast Cancer Cells ◽  
Molecular Effects

Cellular and Molecular Effects of Hydroxycarbamide in Sickle Cell Patients

2014 ◽  
Vol 12 (2) ◽  
pp. 114-122
Author(s):  
Ana Silva-Pinto ◽  
Rita Carrara ◽  
Patricia Palma ◽  
Marco Zago ◽  
Jacques Elion ◽  
...  
Keyword(s):  
Sickle Cell ◽  
Molecular Effects

OP0188 Tocilizumab and Rituximab, but Not Adalimumab, Display Highly Concordant Molecular Effects in the Rheumatoid Arthritis Synovium

2013 ◽  
Vol 72 (Suppl 3) ◽  
pp. A116.2-A116
Author(s):  
J. Ducreux ◽  
P. Durez ◽  
A. Nzeusseu Toukap ◽  
F. A. Houssiau ◽  
B. R. Lauwerys
Keyword(s):  
Rheumatoid Arthritis ◽  
Rheumatoid Arthritis Synovium ◽  
Molecular Effects

scholarly journals Molecular effects and retinopathy induced by hydroxychloroquine during SARS-CoV-2 therapy: Role of CYP450 isoforms and epigenetic modulations

2020 ◽  
Vol 886 ◽  
pp. 173454 ◽  
Author(s):  
Alireza Paniri ◽  
Mohammad Mahdi Hosseini ◽  
Ahmad Rasoulinejad ◽  
Haleh Akhavan-Niaki
Keyword(s):  
Molecular Effects

scholarly journals Insights on autophagosome–lysosome tethering from structural and biochemical characterization of human autophagy factor EPG5

2021 ◽  
Vol 4 (1) ◽  
Author(s):  
Sung-Eun Nam ◽  
Yiu Wing Sunny Cheung ◽  
Thanh Ngoc Nguyen ◽  
Michael Gong ◽  
Samuel Chan ◽  
...  
Keyword(s):  
Biochemical Characterization ◽  
Late Endosome ◽  
Multisystem Disorder ◽  
Cytoplasmic Material ◽  
Disease Mutations ◽  
Evolutionarily Conserved ◽  
Overall Stability ◽  
Transport Vesicle ◽  
Molecular Effects

AbstractPivotal to the maintenance of cellular homeostasis, macroautophagy (hereafter autophagy) is an evolutionarily conserved degradation system that involves sequestration of cytoplasmic material into the double-membrane autophagosome and targeting of this transport vesicle to the lysosome/late endosome for degradation. EPG5 is a large-sized metazoan protein proposed to serve as a tethering factor to enforce autophagosome–lysosome/late endosome fusion specificity, and its deficiency causes a severe multisystem disorder known as Vici syndrome. Here, we show that human EPG5 (hEPG5) adopts an extended “shepherd’s staff” architecture. We find that hEPG5 binds preferentially to members of the GABARAP subfamily of human ATG8 proteins critical to autophagosome–lysosome fusion. The hEPG5–GABARAPs interaction, which is mediated by tandem LIR motifs that exhibit differential affinities, is required for hEPG5 recruitment to mitochondria during PINK1/Parkin-dependent mitophagy. Lastly, we find that the Vici syndrome mutation Gln336Arg does not affect the hEPG5’s overall stability nor its ability to engage in interaction with the GABARAPs. Collectively, results from our studies reveal new insights into how hEPG5 recognizes mature autophagosome and establish a platform for examining the molecular effects of Vici syndrome disease mutations on hEPG5.

scholarly journals Chirality Matters: Biological Activity of Optically Pure Silybin and Its Congeners

2021 ◽  
Vol 22 (15) ◽  
pp. 7885
Author(s):  
Vladimír Křen
Keyword(s):  
Neurological Diseases ◽  
Biological Effects ◽  
Drug Metabolizing Enzymes ◽  
Metabolizing Enzymes ◽  
Biological Targets ◽  
Molecular Effects ◽  
Anisotropic Systems ◽  
Specific Activities ◽  
Optically Pure

This review focuses on the specific biological effects of optically pure silymarin flavo-nolignans, mainly silybins A and B, isosilybins A and B, silychristins A and B, and their 2,3-dehydro derivatives. The chirality of these flavonolignans is also discussed in terms of their analysis, preparative separation and chemical reactions. We demonstrated the specific activities of the respective diastereomers of flavonolignans and also the enantiomers of their 2,3-dehydro derivatives in the 3D anisotropic systems typically represented by biological systems. In vivo, silymarin flavonolignans do not act as redox antioxidants, but they play a role as specific ligands of biological targets, according to the “lock-and-key” concept. Estrogenic, antidiabetic, anticancer, antiviral, and antiparasitic effects have been demonstrated in optically pure flavonolignans. Potential application of pure flavonolignans has also been shown in cardiovascular and neurological diseases. Inhibition of drug-metabolizing enzymes and modulation of multidrug resistance activity by these compounds are discussed in detail. The future of “silymarin applications” lies in the use of optically pure components that can be applied directly or used as valuable lead structures, and in the exploration of their true molecular effects.

scholarly journals Functional and Molecular Effects of Arginine Butyrate and Prednisone on Muscle and Heart in the mdx Mouse Model of Duchenne Muscular Dystrophy

PLoS ONE ◽  
2010 ◽  
Vol 5 (6) ◽  
pp. e11220 ◽  
Author(s):  
Alfredo D. Guerron ◽  
Rashmi Rawat ◽  
Arpana Sali ◽  
Christopher F. Spurney ◽  
Emidio Pistilli ◽  
...  
Keyword(s):  
Duchenne Muscular Dystrophy ◽  
Muscular Dystrophy ◽  
Mouse Model ◽  
Mdx Mouse ◽  
Molecular Effects ◽  
Arginine Butyrate
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