scholarly journals Sensitivity analysis of FDA´s benchmark nozzle regarding in vitro imperfections - Do we need asymmetric CFD benchmarks?

2020 ◽  
Vol 6 (3) ◽  
pp. 78-81
Author(s):  
Michael Stiehm ◽  
Christoph Brandt-Wunderlich ◽  
Stefan Siewert ◽  
Klaus-Peter Schmitz ◽  
Niels Grabow ◽  
...  
Keyword(s):  
Reynolds Number ◽  
Flow Field ◽  
In Silico ◽  
Nozzle Geometry ◽  
Geometrical Imperfection ◽  
Custom Made ◽  
Inlet Conditions ◽  
Silicone Model ◽  
Bench Testing

AbstractModern technologies and methods such as computer simulation, so-called in silico methods, foster the development of medical devices. For accelerating the uptake of computer simulations and to increase credibility and reliability the U.S. Food and Drug Administration organized an inter-laboratory round robin study of a generic nozzle geometry. In preparation of own bench testing experiment using Particle Image Velocimetry, a custom made silicone nozzle was manufactured. By using in silico computational fluid dynamics method the influence of in vitro imperfections, such as inflow variations and geometrical deviations, on the flow field were evaluated. Based on literature the throat Reynolds number was varied Rethroat = 500 ± 50. It could be shown that the flow field errors resulted from variations of inlet conditions can be largely eliminated by normalizing if the Reynolds number is known. Furthermore, a symmetric imperfection of the silicone model within manufacturing tolerance does not affect the flow as much as an asymmetric failure such as an unintended curvature of the nozzle. In brief, we can conclude that geometrical imperfection of the reference experiment should be considered accordingly to in silico modelling. The question arises, if an asymmetric benchmark for biofluid analysis needs to be established. An eccentric nozzle benchmark could be a suitable case and will be further investigated.

scholarly journals Framework for patient-ventilator asynchrony during long-term non-invasive ventilation

Thorax ◽  
2019 ◽  
Vol 74 (7) ◽  
pp. 715-717 ◽  
Author(s):  
Jesus Gonzalez-Bermejo ◽  
Jean-Paul Janssens ◽  
Claudio Rabec ◽  
Christophe Perrin ◽  
Frédéric Lofaso ◽  
...  
Keyword(s):  
Present Report ◽  
Time Windows ◽  
Clinical Impact ◽  
Positive Pressure ◽  
Systematic Analysis ◽  
Non Invasive ◽  
Non Invasive Ventilation ◽  
Polygraphic Recordings ◽  
Bench Testing

Episodes of patient-ventilator asynchrony (PVA) occur during acute and chronic non-invasive positive pressure ventilation (NIV). In long-term NIV, description and quantification of PVA is not standardised, thus limiting assessment of its clinical impact. The present report provides a framework for a systematic analysis of polygraphic recordings of patients under NIV for the detection and classification of PVA validated by bench testing. The algorithm described uses two different time windows: rate asynchrony and intracycle asynchrony. This approach should facilitate further studies on prevalence and clinical impact of PVA in long-term NIV.

System Level Bench Test for Trailing Arm Strength Estimation

2006 ◽  
Author(s):  
Jaychandar Muthu ◽  
Kanak Soundrapandian ◽  
Jyoti Mukherjee
Keyword(s):  
Failure Mode ◽  
Real Life ◽  
Element Model ◽  
Suspension System ◽  
System Level ◽  
Bench Test ◽  
Component Level ◽  
Arm Strength ◽  
Bench Testing ◽  
Nonlinear Finite Element Model

For suspension components, bench testing for strength is mostly accomplished at component level. However, replicating loading and boundary conditions at the component level in order to simulate the suspension system environment may be difficult. Because of this, the component's bench test failure mode may not be similar to its real life failure mode in vehicle environment. A suspension system level bench test eliminates most of the discrepancies between simulated component level and real life vehicle level environments resulting in higher quality bench tests yielding realistic test results. Here, a suspension level bench test to estimate the strength of its trailing arm link is presented. A suspension system level nonlinear finite element model was built and analyzed using ABAQUS software. The strength loading was applied at the wheel end. The analysis results along with the hardware test correlations are presented. The reasons why a system level test is superior to a component level one are also highlighted.

Bench Testing of Manual Riveting Hammers

2021 ◽  
Vol 41 (11) ◽  
pp. 999-1008
Author(s):  
V. S. Vanaev
Keyword(s):  
Bench Testing
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