scholarly journals Design of NW TFET biosensor for enhanced sensitivity and sensing speed by using cavity extension and additional source electrode

2019 ◽  
Vol 14 (8) ◽  
pp. 901-905 ◽  
Author(s):  
Deepak Soni ◽  
Dheeraj Sharma
2003 ◽  
Author(s):  
Cynthia L. Pickett ◽  
Wendi L. Gardner ◽  
Megan Knowles

Author(s):  
Maria Ntinou

Wood charcoal analysis at the Sanctuary of Poseidon at Kalaureia, Poros aims to provide information on the vegetation of the area and its management and on the range of plants used in the activities taking place at the sanctuary. During the excavations of 2003–2005 in Areas D and C, systematic samples from fills and features from all the excavated strata were recovered and water flotation was used for the separation of wood charcoal from the sediment. Wood charcoal was found in two pits dated to the Early Iron Age, near the supposed altar of the Archaic period (Feature 05), in a deposit of the Hellenistic period (the “dining deposit”), in floor deposits (Early Iron Age and Late Classical/Early Hellenistic periods), and fills of different chrono-cultural periods (Archaic–Early Roman). All the taxa identified in the wood charcoal assemblages are thermophilous Mediterranean elements, most of them evergreen broad-leaved. The assemblages show that the most frequent taxon is the olive, followed by the prickly oak, the Fabaceae, and the heather. In most assemblages mock privet/buckthorn, strawberry tree, the pear and Prunus family species are present, while Aleppo pine, lentisc, the fig, and the carob trees are less frequent. Olive cultivation was an important economic activity during the whole life of the sanctuary and probably olive pruning constantly provided the sanctuary with fuel. The woodland would be the additional source of firewood for the sanctuary’s needs for fuel for mundane activities such as heating and cooking, for more formal ones, such as sacrifice, but also for industrial activities such as tile firing. Activities related to the reorganization of space and the expansion of the sanctuary may be reflected in charcoal of carpentry by-products as the fir, cypress, and maybe pine remains.


Analgesia ◽  
1995 ◽  
Vol 1 (4) ◽  
pp. 461-464 ◽  
Author(s):  
A. Honkanen ◽  
E.R. Korpi ◽  
L. Ahtee
Keyword(s):  

2019 ◽  
Vol 16 (4) ◽  
pp. 267-276
Author(s):  
Qurat ul Ain Farooq ◽  
Noor ul Haq ◽  
Abdul Aziz ◽  
Sara Aimen ◽  
Muhammad Inam ul Haq

Background: Mass spectrometry is a tool used in analytical chemistry to identify components in a chemical compound and it is of tremendous importance in the field of biology for high throughput analysis of biomolecules, among which protein is of great interest. Objective: Advancement in proteomics based on mass spectrometry has led the way to quantify multiple protein complexes, and proteins interactions with DNA/RNA or other chemical compounds which is a breakthrough in the field of bioinformatics. Methods: Many new technologies have been introduced in electrospray ionization (ESI) and Matrixassisted Laser Desorption/Ionization (MALDI) techniques which have enhanced sensitivity, resolution and many other key features for the characterization of proteins. Results: The advent of ambient mass spectrometry and its different versions like Desorption Electrospray Ionization (DESI), DART and ELDI has brought a huge revolution in proteomics research. Different imaging techniques are also introduced in MS to map proteins and other significant biomolecules. These drastic developments have paved the way to analyze large proteins of >200kDa easily. Conclusion: Here, we discuss the recent advancement in mass spectrometry, which is of great importance and it could lead us to further deep analysis of the molecules from different perspectives and further advancement in these techniques will enable us to find better ways for prediction of molecules and their behavioral properties.


Author(s):  
Breandán Mac Suibhne

Financial concerns were a factor in McGlynn’s decision to contact Cruise in late March 1856. So too was a fear that he would be connected to a letter threatening Gallagher which he had written at the behest of the Mollies. That anxiety, in turn, stemmed from the fractious politics of the local lodge. The previous year, its ‘master’ had survived a challenge from militants who thought that he should be ordering more ‘outrages’. However, the militants remained a strong faction in the lodge. McGlynn’s fear heightened when the savage beating of a man in a neighbouring parish caused the Catholic clergy to condemn the Mollies. McGlynn’s information revealed Gallagher’s neglect of his aged father, John, to have been an additional source of the Mollies’ animosity to him; so too, it seems, was the death of a man struck with a whip by a relative of his wife.


BioTechniques ◽  
2004 ◽  
Vol 36 (2) ◽  
pp. 334-336 ◽  
Author(s):  
Keqin Gregg ◽  
Wenli Zhou ◽  
Wan Ji ◽  
Sara Davis
Keyword(s):  

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Arkadiusz Miazek ◽  
Michał Zalas ◽  
Joanna Skrzymowska ◽  
Bryan A. Bogin ◽  
Krzysztof Grzymajło ◽  
...  

AbstractThe neuronal membrane-associated periodic spectrin skeleton (MPS) contributes to neuronal development, remodeling, and organization. Post-translational modifications impinge on spectrin, the major component of the MPS, but their role remains poorly understood. One modification targeting spectrin is cleavage by calpains, a family of calcium-activated proteases. Spectrin cleavage is regulated by activated calpain, but also by the calcium-dependent binding of calmodulin (CaM) to spectrin. The physiologic significance of this balance between calpain activation and substrate-level regulation of spectrin cleavage is unknown. We report a strain of C57BL/6J mice harboring a single αII spectrin point mutation (Sptan1 c.3293G > A:p.R1098Q) with reduced CaM affinity and intrinsically enhanced sensitivity to calpain proteolysis. Homozygotes are embryonic lethal. Newborn heterozygotes of either gender appear normal, but soon develop a progressive ataxia characterized biochemically by accelerated calpain-mediated spectrin cleavage and morphologically by disruption of axonal and dendritic integrity and global neurodegeneration. Molecular modeling predicts unconstrained exposure of the mutant spectrin’s calpain-cleavage site. These results reveal the critical importance of substrate-level regulation of spectrin cleavage for the maintenance of neuronal integrity. Given that excessive activation of calpain proteases is a common feature of neurodegenerative disease and traumatic encephalopathy, we propose that damage to the spectrin MPS may contribute to the neuropathology of many disorders.


2021 ◽  
Author(s):  
Meng Yang ◽  
Feng Xie ◽  
Shan-Shan Li ◽  
Chu-Hong Lin ◽  
Xing-Jiu Huang ◽  
...  

A novel zero-valent iron nanomaterial (Fe0@Fe2MnO4) was synthesized and achieved an ultrasensitive electrochemical detection of As(III). It was found that the enhanced sensitivity is attributed to the surficial catalytic redox...


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