Assessing the physical and mechanical properties of poly 3‐hydroxybutyrate‐chitosan‐multi‐walled carbon nanotube/silk nano–micro composite scaffold for long‐term healing tissue engineering applications

2018 ◽  
Vol 13 (6) ◽  
pp. 829-834 ◽  
Author(s):  
Mohammad H. Mirmusavi ◽  
Saeed Karbasi ◽  
Dariush Semnani ◽  
Mohammad Rafienia ◽  
Anousheh Zargar Kharazi
CORD ◽  
2011 ◽  
Vol 27 (1) ◽  
pp. 8
Author(s):  
U.S. Sarma

Coir geotextiles find application in revegetation of slopes by stabilizing the soil through erosion control. It has been found that the longevity of coir geotextiles although highest among all the natural fibres, it is required to last for at least 5 years so as to sustain the vegetation on the slopes for a long term solution. Normally it is found that coir geotextiles lose their 50% strength in 6 months in contact with soil, therefore it is required to strengthen the coir geotextiles. This work involves the coating of coir geotextiles with natural rubber latex which could enhance the longevity of coir geotextiles in various civil/bio engineering applications. The rubber latex coated coir geotextiles which are eco-friendly have superior mechanical properties and better durability compared to the conventional uncoated coir geotextiles. This paper reports the coating of coir geotextile using natural rubber latex and a comparative study of the physical and mechanical properties of the treated and untreated coir geotextiles.


Author(s):  
Linus H. Leung ◽  
Amanda DiRosa ◽  
Hani E. Naguib

Tissue engineering using bioscaffolds is a promising technique that may provide new treatments for various diseases and injuries. These bioscaffolds can be temporary or permanent materials that can be implanted in a patient for tissue repair. Poly(ε-caprolactone) (PCL) is a biocompatible and biodegradable polymer, and hence suitable for usage in tissue engineering applications. Depending on the targeted tissue to be repaired, scaffold properties need to be altered to match that of the tissue. In load bearing applications, such as bone repair, the mechanical properties need to be sufficiently high to prevent material failure. To strengthen the scaffold, various composites have been proposed in the literature, and one of these composites includes PCL with hydroxyapatite (HA). To be able to control the processing of these materials into scaffolds, the characterization of fundamental material properties need to be investigated. In this study, the physical, thermal, mechanical, and viscoelastic properties of PCL:HA at three different weight compositions of 80:20, 70:30, and 60:40 wt% were characterized and compared to neat PCL. PCL/HA composites were fabricated by blending using a twin-screw compounder, and disc-shaped samples were fabricated by compression molding at an elevated temperature. Analysis using a differential scanning calorimeter demonstrated that the glass transition and melting temperatures of the composites remained nearly unaffected by the HA content at −56 °C and 56 °C, respectively; however, depending on the cooling method used for processing, the degree of crystallinity can be controlled. Thermogravimetric analysis was also performed to study the thermal degradation profile. PCL-HA composite samples were tested in compression to determine the effects of HA content on the mechanical properties. Compared to neat PCL, incorporating HA at 40 wt% increased the modulus nearly twofold from 85 to 155 MPa. Lastly, to study the viscoelastic properties of the solid materias, frequency dependency and creep experiments were performed using a dynamic mechanical analyzer. The composites at high HA concentrations were more compliant to creep and other viscoelastic effects. The results found in this study are important in developing novel processing techniques or scaffolds and in controlling final scaffold properties such that any desired properties may be fabricated.


2010 ◽  
Vol 6 (3) ◽  
pp. 735-742 ◽  
Author(s):  
Superb K. Misra ◽  
F. Ohashi ◽  
Sabeel P. Valappil ◽  
Jonathan C. Knowles ◽  
I. Roy ◽  
...  

2015 ◽  
Vol 3 (23) ◽  
pp. 4679-4689 ◽  
Author(s):  
Ya-Ping Guo ◽  
Jun-Jie Guan ◽  
Jun Yang ◽  
Yang Wang ◽  
Chang-Qing Zhang ◽  
...  

A bioinspired strategy has been developed to fabricate a hybrid nanostructured hydroxyapatite–chitosan composite scaffold for bone tissue engineering.


2016 ◽  
Vol 7 (14) ◽  
pp. 2553-2564 ◽  
Author(s):  
Yating Jia ◽  
Weizhong Wang ◽  
Xiaojun Zhou ◽  
Wei Nie ◽  
Liang Chen ◽  
...  

A poly(glycerol sebacate)-based elastomeric copolyesters with improved mechanical properties and higher water uptake capacity.


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