scholarly journals Smith predictor and self-tuning control of muscle-relaxant drug administration

1985 ◽  
Vol 132 (5) ◽  
pp. 212 ◽  
Author(s):  
D.A. Linkens ◽  
M. Menad ◽  
A.J. Asbury
Keyword(s):  
Drug Administration ◽  
Muscle Relaxant ◽  
Smith Predictor ◽  
Self Tuning ◽  
Muscle Relaxant Drug

Self-Tuning PID Control of Muscle-Relaxant Drug Administration in Operating Theatres

1990 ◽  
Vol 23 (1) ◽  
pp. 271-276
Author(s):  
D.A. Linkens ◽  
M. Denai ◽  
A.J. Asbury ◽  
A.D. Macleod ◽  
W.M. Gray
Keyword(s):  
Drug Administration ◽  
Pid Control ◽  
Muscle Relaxant ◽  
Operating Theatres ◽  
Self Tuning ◽  
Muscle Relaxant Drug

A NEW MUSCLE RELAXANT DRUG, PRESTONAL

1959 ◽  
Vol 3 (1) ◽  
pp. 28???29
Author(s):  
J. R. WOODSIDE ◽  
J. DEL ROSARIO ◽  
J. McKEWEN ◽  
D. STUBBS ◽  
GORDON M. WYANT
Keyword(s):  
Muscle Relaxant ◽  
Muscle Relaxant Drug

scholarly journals Sugammadex-Associated Hypotension, Bradycardia, Asystole, and Death

2020 ◽  
Vol 2020 ◽  
pp. 1-2
Author(s):  
Kazim Mirza ◽  
Kathryn Landoski ◽  
Dilip Thakar ◽  
Jagtar Heir-Singh ◽  
Timothy Jackson ◽  
...  
Keyword(s):  
United States ◽  
Case Report ◽  
Drug Administration ◽  
Muscle Relaxant ◽  
Case Reports ◽  
The United States ◽  
Binding Agent ◽  
Reversal Agent ◽  
The Family ◽  
Gamma Cyclodextrin

On December 16, 2015, the Food and Drug Administration (FDA) in the United States approved sugammadex (Bridion, Merck and Co), a modified gamma-cyclodextrin, to be used as a reversal agent. It is a first and unique selective nondepolarizing steroidal muscle relaxant (NDSMR) binding agent with a great affinity for rocuronium and vecuronium. However, there have been several recently published case reports of bradycardia and asystole immediately after sugammadex administration for the reversal. This report presents a case of sugammadex administration followed by rapidly progressing bradycardia leading to asystole and subsequent death. The family has provided the written consent to share this case report.

scholarly journals GAMBARAN LAMA KERJA ROKURONIUM PADA PASIEN YANG MENJALANI ANESTESIA UMUM DI INSTALASI BEDAH SENTRAL RSUP. PROF. DR. R. D. KANDOU MANADO

e-CliniC ◽  
2014 ◽  
Vol 2 (2) ◽  
Author(s):  
Ni Wayan Ira L. Dewi ◽  
Harold Tambajong ◽  
Diana Ch. Lalenoh
Keyword(s):  
Endotracheal Tube ◽  
Endotracheal Intubation ◽  
Muscle Relaxant ◽  
Muscle Relaxation ◽  
Muscle Paralysis ◽  
Tube Insertion ◽  
Common Procedure ◽  
Duration Of Action ◽  
Muscle Relaxant Drug ◽  
Descriptive Method

Abstrak: Intubasi endotrakeal merupakan salah satu tindakan yang sering dilakukan, khususnya pada pasien yang menjalani operasi dengan anestesia umum. Intubasi endotrakeal dilakukan dengan memasukan pipa endotrakeal ke dalam trakea. Keberhasilan pemasangan pipa endotrakeal tergantung beberapa hal seperti relaksasi otot, kedalaman anestesia, dan keterampilan operator. Penggunaan obat pelumpuh otot khusunya pelumpuh otot non-depolarisasi lebih sering digunakan karena menghasilkan kondisi intubasi yang cepat dengan efek samping yang lebih minimal. Rokuronium merupakan salah satu obat pelumpuh otot yang banyak digunakan di Indonesia. Lama kerja obat perlu diketahui dengan pasti agar relaksasi otot cukup optimal untuk dilakukannya pembedahan dan derajat kelumpuhan otot dapat dipertahankan dengan melakukan penambahan dosis obat. Penelitian ini bertujuan untuk mengetahui lama kerja dari obat pelumpuh otot rokuronium agar dapat menentukan waktu penambahan dosis obat yang tepat. Penelitian ini menggunakan metode deskriptif dengan sampel sebanyak 10 orang. Hasil penelitian didapatkan lama kerja rokuronium yaitu 34,90 menit. Lama kerja pada laki-laki lebih lama daripada perempuan. Kelompok berat badan 66-75 kg dan kelompok umur 41-47 tahun memiliki lama kerja yang paling panjang. Kata kunci: Lama kerja, rokuronium.     Abstract: Endotracheal intubation is one of the most common procedure, especially on a patient undergoing surgery with general anesthesia. Endotracheal intubation is done by inserting endotracheal tube into trachea. The success of endotracheal tube insertion depends on several things such as muscle relaxation, the depth of anesthesia, and the operator’s skill. The use of muscle relaxant drugs especially non-depolarization muscle relaxant is more frequently because it produces rapid intubation conditions with minimal side effect. Rocuronium is a muscle relaxant drug that is widely used in Indonesia. Duration of action of drugs need to be known for certain so the optimal muscle relaxation sufficient to do the surgery and the degree of muscle paralysis can be maintained by adding a dose of the drug. This study aims to determine the duration of action of rocuronium in order to determine the time to administer proper dose addition. This study used a descriptive method with a sample of 10 people. The results showed that the duration of action of rocuronium is 34,90 minutes. The duration of action on men is longer than women. Longest duration of action occurs on 66-75 Kg weight group and 41-47 age group Keyword: Duration of action, rocuronium.

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