Analysis of long-term absolute-frequency stabilisation of a bulk 1.5 [micro sign]m erbium microlaser to a grid of nine different wavelengths

1998 ◽  
Vol 34 (1) ◽  
pp. 81 ◽  
Author(s):  
S. Taccheo ◽  
G. Sorbello ◽  
P. Laporta ◽  
C. Svelto
Keyword(s):  
Absolute Frequency ◽  
Frequency Stabilisation

Long-term stable operation and absolute frequency stabilization of a doubly resonant parametric oscillator

1998 ◽  
Vol 66 (6) ◽  
pp. 733-739 ◽  
Author(s):  
R. Al-Tahtamouni ◽  
K. Bencheikh ◽  
R. Storz ◽  
K. Schneider ◽  
M. Lang ◽  
...  
Keyword(s):  
Frequency Stabilization ◽  
Parametric Oscillator ◽  
Stable Operation ◽  
Absolute Frequency

Absolute frequency stabilisation of a 637 nm laser diode using Doppler-free I2 spectra

1995 ◽  
Vol 31 (10) ◽  
pp. 796-797 ◽  
Author(s):  
C.S. Edwards ◽  
P. Gill ◽  
W.R.C. Rowley ◽  
G.P. Barwood
Keyword(s):  
Laser Diode ◽  
Absolute Frequency ◽  
Frequency Stabilisation

scholarly journals Persistence of leukemia stem cells in chronic myelogenous leukemia patients in prolonged remission with imatinib treatment

Blood ◽  
2011 ◽  
Vol 118 (20) ◽  
pp. 5565-5572 ◽  
Author(s):  
Su Chu ◽  
Tinisha McDonald ◽  
Allen Lin ◽  
Sujata Chakraborty ◽  
Qin Huang ◽  
...  
Keyword(s):  
Stem Cells ◽  
Chronic Myelogenous Leukemia ◽  
Myelogenous Leukemia ◽  
Leukemia Cells ◽  
Prolonged Treatment ◽  
Molecular Response ◽  
Imatinib Treatment ◽  
Absolute Frequency

Abstract Imatinib mesylate treatment markedly reduces the burden of leukemia cells in chronic myelogenous leukemia (CML) patients. However, patients remain at risk for relapse on discontinuing treatment. We have previously shown that residual BCR-ABL+ progenitors can be detected in CML patients within the first 2 years of imatinib treatment. However, reduced rates of relapse and continued decline of BCR-ABL levels with prolonged treatment, together with the ability of selected patients to maintain remission after discontinuing treatment, led us to investigate whether prolonged imatinib exposure resulted in reduction or elimination of BCR-ABL+ stem cells. We evaluated BCR-ABL expression in CD34+CD38+ (38+) committed progenitors and CD34+CD38− (38−) stem/primitive progenitor cells in samples from CML patients on imatinib treatment for at least 4 years with cytogenetic and molecular response. High levels of BCR-ABL expression were maintained over time in the 38− stem cell fraction. The absolute frequency of BCR-ABL+ cells as determined by limiting dilution analysis was consistently higher in 38− compared with 38+ cells. Transplantation into NOD/SCID-IL2Rγ-chain knockout mice demonstrated that BCR-ABL+ cells had long-term in vivo repopulating capacity. These results directly demonstrate that BCR-ABL+ stem cells persist in CML patients despite prolonged treatment with imatinib, and support ongoing efforts to target this population.

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