Early‐stage microfluidic network design framework using graph sparsificiation based optimisation

2019 ◽  
Vol 55 (19) ◽  
pp. 1034-1037
Author(s):  
Shunjie Dong ◽  
Weiqing Ji ◽  
Hailong Yao ◽  
Cheng Zhuo
Keyword(s):  
Network Design ◽  
Early Stage ◽  
Design Framework ◽  
Microfluidic Network

Five-cross microfluidic network design free of coupling between electrophoretic motion and electro-osmotic flow

2006 ◽  
Vol 89 (8) ◽  
pp. 084101 ◽  
Author(s):  
Xin Hu ◽  
Shengnian Wang ◽  
Yi-Je Juang ◽  
L. James Lee
Keyword(s):  
Network Design ◽  
Osmotic Flow ◽  
Microfluidic Network ◽  
Electro Osmotic Flow

scholarly journals A Parametric Product Design Framework for the Development of Mass Customized Head/Face (Eyewear) Products

2021 ◽  
Vol 11 (12) ◽  
pp. 5382
Author(s):  
Xiaobo Bai ◽  
Omar Huerta ◽  
Ertu Unver ◽  
James Allen ◽  
Jane E. Clayton
Keyword(s):  
Product Development ◽  
Product Design ◽  
New Product Development ◽  
Mass Customization ◽  
Parametric Design ◽  
Early Stage ◽  
New Product ◽  
Parametric Modelling ◽  
Design Framework ◽  
Human Face

This study led to the development of a parametric design method for mass-customised head/face products. A systematic review of different approaches for mass customization was conducted, identifying advantages and limitations for their application to new product development. A parametric modelling algorithm of a 3D human face was developed using selected scanned 3D head models. The algorithm was developed from a set of measurable and adjustable parameter points related to the facial geometry. These parameters were defined using planimetry. Using the assigned parameter values as input, the parametric model generated 3D models of a human face that served as a reference for the design of customized eyewear. The current challenges and opportunities of mass customized head/face products are described, along with the possibilities for new parametric product design approaches to enable rapid manufacturing and mass customization. This study also explored whether a new parametric design framework for mass customization could be effectively implemented as an early-stage new product development strategy for head/face products.

Alterations in the number of motoneurons containing immunoreactive calcitonin gene-related peptide(CGRP)& choline acetyltransferase(ChAT) in the cervical spinal cord of the wobbler mouse during the development of the motoneuron disease

1995 ◽  
Vol 53 ◽  
pp. 970-971
Author(s):  
L. Vacca-Galloway ◽  
Y.Q. Zhang ◽  
P. Bose ◽  
S.H. Zhang
Keyword(s):  
Spinal Cord ◽  
Early Stage ◽  
Cervical Spinal Cord ◽  
Wild Type Mouse ◽  
Reflex Response ◽  
Mouse Strains ◽  
Behavioral Tests ◽  
Wobbler Mouse ◽  
Stage 4 ◽  
Stage 1

The Wobbler mouse (wr) has been studied as a model for inherited human motoneuron diseases (MNDs). Using behavioral tests for forelimb power, walking, climbing, and the “clasp-like reflex” response, the progress of the MND can be categorized into early (Stage 1, age 21 days) and late (Stage 4, age 3 months) stages. Age-and sex-matched normal phenotype littermates (NFR/wr) were used as controls (Stage 0), as well as mice from two related wild-type mouse strains: NFR/N and a C57BI/6N. Using behavioral tests, we also detected pre-symptomatic Wobblers at postnatal ages 7 and 14 days. The mice were anesthetized and perfusion-fixed for immunocytochemical (ICC) of CGRP and ChAT in the spinal cord (C3 to C5).Using computerized morphomety (Vidas, Zeiss), the numbers of IR-CGRP labelled motoneurons were significantly lower in 14 day old Wobbler specimens compared with the controls (Fig. 1). The same trend was observed at 21 days (Stage 1) and 3 months (Stage 4). The IR-CGRP-containing motoneurons in the Wobbler specimens declined progressively with age.

Automated high-resolution microscopy: the approaches so far

1987 ◽  
Vol 45 ◽  
pp. 58-61
Author(s):  
W. O. Saxton
Keyword(s):  
High Resolution ◽  
Early Stage ◽  
Automatic Recording ◽  
Microprocessor Control ◽  
Alternative Systems ◽  
Electron Image ◽  
Complete Automation ◽  
Analysis System ◽  
High Resolution Microscopy

Recent commercial microscopes with internal microprocessor control of all major functions have already demonstrated some of the benefits anticipated from such systems, such as continuous magnification, rotation-free diffraction and magnification, automatic recording of mutually registered focal series, and fewer control knobs. Complete automation of the focusing, stigmating and alignment of a high resolution microscope, allowing focal series to be recorded at preselected focus values as well, is still imminent rather than accomplished, however; some kind of image pick-up and analysis system, fed with the electron image via a TV camera, is clearly essential for this, but several alternative systems and algorithms are still being explored. This paper reviews the options critically in turn, and stresses the need to consider alignment and focusing at an early stage, and not merely as an optional extension to a basic proposal.

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