scholarly journals Controlling of chaos in a tumour growth cancer model: an experimental study

2018 ◽  
Vol 54 (20) ◽  
pp. 1160-1162
Author(s):  
S. Sabarathinam ◽  
K. Thamilmaran
Keyword(s):  
Experimental Study ◽  
Tumour Growth ◽  
Cancer Model ◽  
Controlling Of Chaos

scholarly journals Nonlinear active control of a cancerous tumour

2018 ◽  
Vol 7 (2.21) ◽  
pp. 72 ◽  
Author(s):  
Bhabani Shankar Dey ◽  
Manas Kumar Bera ◽  
Binoy Krishna Roy
Keyword(s):  
Active Control ◽  
Immune Cells ◽  
Normal Cell ◽  
Tumour Growth ◽  
Three Dimensional ◽  
Tumour Cells ◽  
Host Cells ◽  
Cancer Model ◽  
Control Objective ◽  
Simulation Results

This paper deals with the control of a cancerous tumour growth. The model used is a Three-Dimensional Cancer Model (TDCM). The competition terms include tumour cells, healthy cells, and immune cells. Nature of the competition among the populations of tumour cells, healthy host cells, and immune cells results in a chaotic behaviour. In this paper, a nonlinear active control has been used to control the growth of a tumour. Effect of chemotherapy drug on the different cell populations has been studied. Our control objective is to control the tumour growth and minimize its population to a small value which can be considered as harmless.Along with the above objective, the normal cell population is also be maintained at a particular level. This work has been done completely inin-sillico environment. The simulation results are shown extensively to support the theoretical analysis and confirmed that the preliminary objectives of the paper are attained.  

scholarly journals Aerosolised 5-azacytidine suppresses tumour growth and reprogrammes the epigenome in an orthotopic lung cancer model

2013 ◽  
Vol 109 (7) ◽  
pp. 1775-1781 ◽  
Author(s):  
M D Reed ◽  
C S Tellez ◽  
M J Grimes ◽  
M A Picchi ◽  
M Tessema ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Tumour Growth ◽  
Cancer Model ◽  
Lung Cancer Model

BLOOD TRANSFUSION AND TUMOUR GROWTH: AN EXPERIMENTAL STUDY

1985 ◽  
Vol 55 (5) ◽  
pp. 503-506 ◽  
Author(s):  
R. T. Judson ◽  
L. Robb ◽  
A. J. F. D'Apice
Keyword(s):  
Experimental Study ◽  
Blood Transfusion ◽  
Tumour Growth

scholarly journals Effect of Haishengsu on transplanted K562 and drug-resistant K562/ADM tumors: An experimental study

2009 ◽  
Vol 32 (2) ◽  
pp. 117 ◽  
Author(s):  
Ji-Zhu Liu ◽  
Ming Yang ◽  
Da-Peng Li ◽  
Bin Zhang ◽  
Shou-Guo Chen ◽  
...  
Keyword(s):  
Experimental Study ◽  
Combination Therapy ◽  
Tumour Growth ◽  
Low Dose ◽  
K562 Cells ◽  
Pathological Examination ◽  
Drug Resistant ◽  
Inhibitory Rate ◽  
Extensive Necrosis ◽  
Anti Tumour Effect

Purpose: To evaluate the effect of Haishengsu (HSS) on transplanted K562 and drug-resistant K562/ADM tumors. Methods: Mice were inoculated subcutaneously with K562 and K562/ADM cells, respectively. Tumour-bearing animals were divided into HSS, adriamycin, combination therapy (adriamycin plus HSS) and placebo groups. The anti-tumour effect was assessed by tumour growth curve and tumour inhibitory rate (IR). Results: In animals inoculated with K562 cells, the inhibitory rates of high (1800mg/kg) and medium (900mg/kg ) dose HSS groups were 100% and 96.4%, respectively, which was higher than that in the adriamycin (88.9%) or the combination therapy groups (85.8%, P < 0.05). The inhibitory rate in the low-dose HSS group (53.4%) was lower than in all other groups (P < 0.01). In mice inoculated with K562/ADM cells, the inhibitory rates in the high, medium and low dose HSS groups were 100%, 95.9%, and 44.1%, respectively. In the adriamycin group, the inhibitory rate was 23.07%, which was lower than in the HSS group (P < 0.01). Pathological examination of tumour tissues from HSS-treated animals showed extensive necrosis and bleeding. Conclusions: Haishengsu inhibits the growth of transplanted K562 tumours in mice. It is also effective in suppressing the growth of drug-resistant K562/ADM tumors in this animal model.

scholarly journals Alphavirus-driven Interferon Gamma (IFNg) Expression Inhibits Tumour Growth in Orthotopic 4T1 Breast Cancer Model

2021 ◽  
Author(s):  
Olga Trofimova ◽  
Ksenija Korotkaja ◽  
Dace Skrastina ◽  
Juris Jansons ◽  
Karina Spunde ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Interferon Gamma ◽  
Tumour Growth ◽  
Semliki Forest Virus ◽  
Myeloid Cell ◽  
T Cell Response ◽  
Lymphoid Cells ◽  
Cancer Model ◽  
Virus Particles ◽  
Breast Cancer Model

Interferon gamma (IFNg) is a pleiotropic cytokine that can potentially reprogramme the tumour microenvironment. However, the antitumour immunomodulatory properties of IFNg still need to be validated due to variable therapeutic outcomes in preclinical and clinical studies. We developed a replication-deficient Semliki Forest virus vector expressing IFNg (SFV/IFNg) and evaluated its immunomodulatory antitumour potential in vitro in a model of 3D spheroids and in vivo in immunocompetent 4T1 mouse breast cancer model. We demonstrated that SFV-derived IFN-g stimulated bone marrow macrophages to acquire the tumoricidal M1 phenotype in 3D nonattached conditions. Coculturing SFV/IFNg-infected 4T1 spheroids with BMDMs inhibited spheroid growth. In the orthotopic 4T1 mouse model, intratumoural administration of SFV/IFNg virus particles alone or in combination with the Pam3CSK4 TLR2/1 ligand led to significant inhibition of tumour growth compared to the administration of the control SFV/Luc virus particles. Analysis of the composition of intra-tumoural lymphoid cells isolated from tumours after SFV/IFNg treatment revealed an increase in CD4+ and CD8+ and a decrease in T-reg (CD4+/CD25+/FoxP3+) cell populations. Furthermore, a significant decrease in the populations of cells bearing myeloid cell markers CD11b, CD38 and CD206 was observed. In conclusion, the SFV/IFNg vector induces a therapeutic antitumour T-cell response and inhibits myeloid cell infiltration in treated tumours.

scholarly journals Targeting cMET with INC280 impairs tumour growth and improves efficacy of gemcitabine in a pancreatic cancer model

BMC Cancer ◽  
2015 ◽  
Vol 15 (1) ◽  
Author(s):  
Franziska Brandes ◽  
Katharina Schmidt ◽  
Christine Wagner ◽  
Julia Redekopf ◽  
Hans Jürgen Schlitt ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Tumour Growth ◽  
Cancer Model
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