Picodroplet Mass Spectrometry for Miniaturized High Throughput Analysis of Synthetic Biology Microbial Clones

2016 ◽  
Author(s):  
X. Li ◽  
M.J. Brown ◽  
C.A. Smith ◽  
G. Cooper ◽  
X. Liu ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Synthetic Biology ◽  
High Throughput ◽  
High Throughput Analysis ◽  
Throughput Analysis

scholarly journals Novel Interface for High-Throughput Analysis of Biotherapeutics by Electrospray Mass Spectrometry

2019 ◽  
Vol 92 (2) ◽  
pp. 2186-2193 ◽  
Author(s):  
Hae-Min Park ◽  
Valerie J. Winton ◽  
Jared J. Drader ◽  
Sheri Manalili Wheeler ◽  
Greg A. Lazar ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
High Throughput ◽  
Electrospray Mass Spectrometry ◽  
High Throughput Analysis ◽  
Throughput Analysis

High-throughput analysis of peptides and proteins by laserspray ionization mass spectrometry

2010 ◽  
Vol 25 (1) ◽  
pp. 247-250 ◽  
Author(s):  
Alicia L. Richards ◽  
Darrell D. Marshall ◽  
Ellen D. Inutan ◽  
Charles N. McEwen ◽  
Sarah Trimpin
Keyword(s):  
Mass Spectrometry ◽  
High Throughput ◽  
Ionization Mass Spectrometry ◽  
Ionization Mass ◽  
High Throughput Analysis ◽  
Throughput Analysis ◽  
Laserspray Ionization

scholarly journals High-Throughput Analysis from Complex Matrices: Acoustic Ejection Mass Spectrometry from Phase-Separated Fluid Samples

Metabolites ◽  
2021 ◽  
Vol 11 (11) ◽  
pp. 789
Author(s):  
Yuzhu Guo ◽  
Michael Forbush ◽  
Thomas R. Covey ◽  
Lucien Ghislain ◽  
Chang Liu
Keyword(s):  
Mass Spectrometry ◽  
High Throughput ◽  
Complex Matrices ◽  
Two Phase ◽  
High Throughput Analysis ◽  
Throughput Analysis ◽  
Bioanalytical Applications ◽  
Analytical Technology ◽  
Better Than

Acoustic ejection mass spectrometry is a novel high-throughput analytical technology that delivers high reproducibility without carryover observed. It eliminates the chromatography step used to separate analytes from matrix components. Fully-automated liquid–liquid extraction is widely used for sample cleanup, especially in high-throughput applications. We introduce a workflow for direct AEMS analysis from phase-separated liquid samples and explore high-throughput analysis from complex matrices. We demonstrate the quantitative determination of fentanyl from urine using this two-phase AEMS approach, with a LOD lower than 1 ng/mL, quantitation precision of 15%, and accuracy better than ±10% over the range of evaluation (1–100 ng/mL). This workflow offers simplified sample preparation and higher analytical throughput for some bioanalytical applications, in comparison to an LC-MS based approach.

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