2008 Zemlin Award in Speech Sciences Memorial Lecture: The Role of Auditory Feedback for the Control of Voice Fundamental Frequency and Amplitude

2009 ◽  
Vol 19 (1) ◽  
pp. 6-17
Author(s):  
Charles R. Larson
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Fundamental Frequency ◽  
Auditory Feedback ◽  
Event Related Potential ◽  
Neural Mechanisms ◽  
Cortical Activation ◽  
Memorial Lecture ◽  
Voice Fundamental Frequency ◽  
The Voice

Abstract Previous research has failed to identify precise neural mechanisms involved in auditory feedback regulation of vocalization. The goal of this research project was to improve our understanding of neural mechanisms controlling the voice. Participants were instructed to sustain a vowel or repeat phrases during which perturbations in voice pitch or loudness feedback were presented. Voice signal averaging, neuroimaging, laryngeal electromyography, and cortical event-related potential techniques were used to measure vocal and neural responses to perturbed feedback. Pitch- and loudness-shifted voice feedback triggers small automatic corrective responses in voice fundamental frequency and amplitude during vowel or speech production. Larger responses during speech suggest task modulation of these responses. Larger responses were also recorded in individuals with Parkinson's disease and children with autism than in normal controls. Neural recording techniques revealed cortical activation during these responses. Cortical mechanisms are involved in generating corrective vocal responses to perturbations in voice auditory feedback. This system helps control the voice during speech and dynamically adjusts responses to meet vocal goals. Abnormally large responses in individuals with Parkinson's disease and autism suggest that the audio-vocal mechanisms just described may be involved in the speech and vocalizations of these individuals as well.

Effect of Duration of Pitch-Shifted Feedback on Vocal Responses in Patients With Parkinson's Disease

2001 ◽  
Vol 44 (5) ◽  
pp. 975-987 ◽  
Author(s):  
Swathi Kiran ◽  
Charles R. Larson
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Basal Ganglia ◽  
Fundamental Frequency ◽  
Auditory Feedback ◽  
Peak Time ◽  
Positive Effects ◽  
End Times ◽  
Voice Fundamental Frequency ◽  
Pitch Shift

Study of the pitch-shift reflex is useful for the investigation of how auditory feedback is used in the control of voice fundamental frequency. The present study was an attempt to learn if the basal ganglia are involved in central mechanisms of the pitch-shift reflex by comparing measures of the reflex in a group of Parkinson's disease patients with those measures in a group of control participants. The effect of varying duration of the pitch-shift stimulus (PSS) on the voice fundamental frequency (F0) response in 10 Parkinson's disease (PD) patients and 10 age-matched unaffected participants was investigated. Participants were instructed to vocalize into a microphone while their voice was fed back to them over headphones. This feedback of the vocal signal was shifted in pitch either up or down, with the duration of this shift systematically manipulated at 100 ms, 500 ms, and 1000 ms. Although the participants were on medication, making interpretation of the results problematic with regard to basal ganglia function, it was reasoned that positive effects could nevertheless suggest basal ganglia involvement in this reflex and motivate further research. Results indicated that both groups responded to increased stimulus duration of the pitch-shift stimulus with increases in reflex peak time, magnitude, and end times. However, PD patients had significantly longer peak times and end times than control participants for stimulus durations of 100 ms. These results suggest that basal ganglia dysfunction may affect mechanisms relating to the execution and termination of the pitch-shift reflex for brief stimulus durations. The results also support hypotheses of impaired sensory integration of auditory feedback in PD patients.

scholarly journals Sensorimotor adaptation of voice fundamental frequency in Parkinson's disease

PLoS ONE ◽  
2018 ◽  
Vol 13 (1) ◽  
pp. e0191839 ◽  
Author(s):  
Defne Abur ◽  
Rosemary A. Lester-Smith ◽  
Ayoub Daliri ◽  
Ashling A. Lupiani ◽  
Frank H. Guenther ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Fundamental Frequency ◽  
Sensorimotor Adaptation ◽  
Voice Fundamental Frequency

scholarly journals Idiopathic Parkinson's disease: vocal and quality of life analysis

2012 ◽  
Vol 70 (9) ◽  
pp. 674-679 ◽  
Author(s):  
Luiza Furtado e Silva ◽  
Ana Cristina Côrtes Gama ◽  
Francisco Eduardo Costa Cardoso ◽  
César Augusto da Conceição Reis ◽  
Iara Barreto Bassi
Keyword(s):  
Quality Of Life ◽  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Fundamental Frequency ◽  
Control Group ◽  
Idiopathic Parkinson’S Disease ◽  
Self Perception ◽  
Idiopathic Parkinson's Disease ◽  
The Voice

OBJECTIVE: To compare voice and life quality of male patients with idiopathic Parkinson's disease, with individuals without disease (Control Group). METHODS: A cross-sectional study that evaluated the voice of individuals with Parkinson's disease, the group was composed of 27 subjects, aged from 39 to 79 years-old (average 59.96). The Control Group was matched on sex and age. Participants underwent voice recording. Perceptual evaluation was made using GRBASI scale, which considers G as the overall degree of dysphonia, R as roughness, B as breathiness, A as asthenia, S as strain and I as instability. The acoustic parameters analyzed were: fundamental frequency, jitter, shimmer, and harmonic to noise ratio (NHR). For vocal self-perception analysis, we used the Voice Related Quality of Life protocol. RESULTS: Fundamental frequency and jitter presented higher values in the Parkinson's group. NHR values were higher in the Control Group. Perceptual analysis showed a deviation ranging. The vocal disorder self-perception demonstrated a worse impact on quality of life. CONCLUSIONS: Individuals with Parkinson's disease have an altered voice quality and a negative impact on quality of life.

Event-related potential P3 change in mild Parkinson's disease

1996 ◽  
Vol 11 (1) ◽  
pp. 32-42 ◽  
Author(s):  
Joanne Green ◽  
John L. Woodard ◽  
Brett E. Sirockman ◽  
Gregory O. Zakers ◽  
Claire L. Maier ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Event Related Potential

scholarly journals Deficits in monitoring self-produced speech in Parkinson’s disease

2019 ◽  
Author(s):  
Henry Railo ◽  
Niklas Nokelainen ◽  
Saara Savolainen ◽  
Valtteri Kaasinen
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Neural Mechanisms ◽  
Speech Impairment ◽  
Self Monitoring ◽  
Evoked Activity ◽  
And Control ◽  
N1 Wave ◽  
Electrophysiological Correlate

AbstractObjectiveSpeech deficits are common in Parkinson’s disease, and behavioural findings suggest that the deficits may be due to impaired monitoring of self-produced speech. The neural mechanisms of speech deficits are not well understood. We examined a well-documented electrophysiological correlate of speech self-monitoring in patients with Parkinson’s disease and control participants.MethodsWe measured evoked electroencephalographic responses to self-produced and passively heard sounds (/a/ phonemes) in age-matched controls (N=18), and Parkinson’s disease patients who had minor speech impairment, but reported subjectively experiencing no speech deficits (N=17).ResultsDuring speaking, auditory evoked activity 100 ms after phonation (N1 wave) was less suppressed in Parkinson’s disease than controls when compared to the activity evoked by passively heard phonemes. This difference between the groups was driven by increased amplitudes to self-produced phonemes, and reduced amplitudes passively heard phonemes in Parkinson’s disease.ConclusionsThe finding indicates that auditory evoked activity is abnormally modulated during speech in Parkinson’s patients who do not subjectively notice speech impairment. This mechanism could play a role in producing speech deficits in as the disease progresses.

scholarly journals Lexical ambiguity resolution during sentence processing in Parkinson’s disease: An event-related potential study

PLoS ONE ◽  
2017 ◽  
Vol 12 (5) ◽  
pp. e0176281 ◽  
Author(s):  
Anthony J. Angwin ◽  
Nadeeka N. W. Dissanayaka ◽  
Katie L. McMahon ◽  
Peter A. Silburn ◽  
David A. Copland
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Sentence Processing ◽  
Ambiguity Resolution ◽  
Lexical Ambiguity ◽  
Event Related Potential ◽  
Lexical Ambiguity Resolution ◽  
Potential Study
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