scholarly journals On Ice: The impact of vitrification on the use of eggs in fertility treatment

2019 ◽  
Vol 3 (6) ◽  
pp. 713-717
Author(s):  
Kylie Baldwin ◽  
Douglas Gray ◽  
Nicky Hudson
Keyword(s):  
Intracytoplasmic Sperm Injection ◽  
Scientific Community ◽  
Clinical Pregnancy ◽  
Fertility Treatment ◽  
Egg Donation ◽  
Men And Women ◽  
Clinical Pregnancy Rates ◽  
The Impact ◽  
Egg Freezing ◽  
Social Egg Freezing

The possibility to freeze sperm and embryos has long been available to men and women facing infertility as a result of an illness or medical treatment. However, the ability to successfully cryopreserve human eggs is comparatively recent. The introduction and increasing use of egg vitrification from the mid-2000s onwards, alongside the use of intracytoplasmic sperm injection, has seen improved ongoing clinical pregnancy rates compared with slow freezing methods. Despite concerns, the technology has been widely embraced by the scientific community and in recent years has been applied in a greater variety of contexts. In this short perspective paper, we consider two specific applications for the vitrification of human eggs in routine assisted reproduction practice: social egg freezing and the use of frozen eggs in egg donation. We suggest that vitrification is transforming the reproductive landscape in novel and complex ways and that we must be alert to the challenges, complexities and ethics of such developments, especially for those who may be excluded or marginalised by these techniques.

Does the Modification of Starting Gonadotropin Dose During ICSI Cycle Have Any Significant Impact on Cycle Outcome?

2017 ◽  
Vol 23 (3) ◽  
pp. 138
Author(s):  
Enis Özkaya ◽  
Yavuz Şahin ◽  
Semra Kayatas Eser ◽  
Betul Albayrak ◽  
Oguzhan Bulduk ◽  
...  
Keyword(s):  
Intracytoplasmic Sperm Injection ◽  
Pregnancy Rates ◽  
Clinical Pregnancy ◽  
High Response ◽  
Estradiol Level ◽  
Standard Group ◽  
Clinical Pregnancy Rates ◽  
The Impact ◽  
Injection Cycle ◽  
Gonadotropin Dosage

<p><strong>OBJECTIVE:</strong> The aim of this study was to figure out the impact of gonadotropin dose alteration requirements due to high response or unresponsiveness on intracytoplasmic sperm injection cycle outcomes in a standard group of patients.</p><p><strong>STUDY DESIGN:</strong> One hundred cycles with same gonadotropin dosage along the stimulation were compared with 100 cycles in which gonadotropin dose alterations were needed due to high response or unresponsiveness. Groups were compared in terms of age, body mass index, serum follicle stimulating hormone and estradiol levels, antral follicle count, gonadotropin dosage, duration of stimulation, endometrial thickness at trigger day, number of total, mature and immature oocytes and finally the clinical pregnancy rates.</p><p><strong>RESULTS:</strong> There were significant differences between groups with regard to gonadotropin starting dose, total gonadotropin dose, duration of stimulation, estradiol level at trigger day, number of total oocytes and metaphase 1 oocyte number. Clinical pregnancy rates were similar between groups.</p><p><strong>CONCLUSION:</strong> Dose alteration requirement along intracytoplasmic sperm injection cycle result in high number of total and metaphase 1 oocyte yields, higher starting gonadotropin and total gonadotropin dose, duration of stimulation and estradiol level at trigger day, however clinical pregnancy rates were similar between groups.</p>

scholarly journals Social egg freezing under public health perspective: Just a medical reality or a women’s right? An ethical case analysis

2018 ◽  
Author(s):  
Ana Borovecki ◽  
Pamela Tozzo ◽  
Nicoletta Cerri ◽  
Luciana Caenazzo
Keyword(s):  
Public Health ◽  
Point Of View ◽  
Reproductive Age ◽  
Public Healthcare ◽  
Proper Solution ◽  
Public Health Perspective ◽  
Age Related ◽  
The Impact ◽  
Egg Freezing ◽  
Social Egg Freezing

In recent years, a social trend toward delaying childbearing has been observed in women of reproductive age. A novel technomedical innovation was commercialized for non-medical reasons to healthy, ostensibly fertile women, who wished to postpone motherhood for various reasons such as educational or career demands, or because they had not yet found a partner. As a consequence, these women may be affected by age-related infertility when they decide to conceive, and fertility preservation techniques can be obtained through the so-called social egg freezing. This paper examines, from an ethical point of view, the impact of social egg freezing under some aspects that can involve policy making and resources allocation in public health. Due to the increasing demand for this procedure, some debated issues regard if it is reasonable to include social egg freezing in Public Healthcare System and consequently how to manage the storage of cryopreserved oocytes also from individual donors, how to support these egg banks and how to face, in the future, with the possibility that egg freezing will play a role in enabling childbearing for gays, lesbians, and unmarried persons. Social freezing may be advertised to harmonise gender differences, but we wonder if it is the proper solution to the problem or if it could also create further challenges. An ethical argumentation on these topics should address some questions that will be discussed.

scholarly journals The impact of social relations among men and women in fertility treatment on the decision to terminate treatment

2012 ◽  
Vol 27 (12) ◽  
pp. 3502-3512 ◽  
Author(s):  
D. Vassard ◽  
R. Lund ◽  
A. Pinborg ◽  
J. Boivin ◽  
L. Schmidt
Keyword(s):  
Social Relations ◽  
Fertility Treatment ◽  
Men And Women ◽  
The Impact

scholarly journals Endometriosis and ART outcome: a retrospective analysis

2021 ◽  
Vol 10 (2) ◽  
pp. 536
Author(s):  
Janani S. ◽  
Kundavi Shankar ◽  
Geetha V. ◽  
Abdul Basith
Keyword(s):  
Retrospective Analysis ◽  
Live Birth ◽  
Birth Rate ◽  
Implantation Rate ◽  
Live Birth Rate ◽  
Clinical Pregnancy ◽  
Fertility Treatment ◽  
Male Factor ◽  
Cumulative Live Birth Rate ◽  
The Impact

Background: Endometriosis affects up to 30-40% of women seeking fertility treatment and is known to reduce fecundity. There remains a debate on the effect of endometriosis on the IVF outcome, with live birth not reported in most studies. This study looks at the impact of endometriosis on live birth rates after IVF and compares the chances of success with those without endometriosis.Methods: Retrospective analysis of women who underwent IVF at our institution for 2 years were included. Multiple factor infertility, ovulation disorders and donor program were excluded. The outcomes were compared for 4 cohorts - women with endometriosis, male factor infertility, tubal factor infertility and unexplained infertility. The primary outcome was live birth rate. Other outcome measures were total dose of gonadotropins used, mean number of oocytes collected, M2 oocyte rate, fertilization rate, implantation rate, and clinical pregnancy rate.Results: Patients diagnosed with endometriosis had lower mean number of oocytes collected (6.86 vs 7.69, 7.94, 7.45) and lower mean number of M2 oocytes (5.31 vs 6.21, 6.44, 5.91) but was not statistically significant. Endometriosis patients required significantly higher dose of gonadotropins when compared to controls (5365.79 IU;  p-0.001). The per ET implantation rate (10.4% vs 17.8%, 22.5%, 19.2%), clinical pregnancy rate (8% vs 15%, 20%, 17%), live birth rate (7.92% vs 16.6%, 15.14%, 12%) and the cumulative live birth rate (27.9% vs 46.5%, 60%, 46.7%) were significantly less in women with endometriosis (p-0.039, p-0.021, p-0.001, p-0.039 respectively) and the effect is more pronounced with increasing disease severity.Conclusions: Endometriosis affects all aspects of IVF outcomes including folliculogenesis, embryo development and implantation. Though ovarian factor can be overruled by increasing the stimulation doses as in our study, methods to improve the implantation rates should be thought about in future. 

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