scholarly journals Regulation of amino acid transporter trafficking by mTORC1 in primary human trophoblast cells is mediated by the ubiquitin ligase Nedd4-2

2016 ◽  
Vol 130 (7) ◽  
pp. 499-512 ◽  
Author(s):  
Fredrick J. Rosario ◽  
Kris Genelyn Dimasuay ◽  
Yoshikatsu Kanai ◽  
Theresa L. Powell ◽  
Thomas Jansson
Keyword(s):  
Plasma Membrane ◽  
Amino Acid ◽  
Ubiquitin Ligase ◽  
Membrane Trafficking ◽  
Molecular Mechanisms ◽  
Acid Transport ◽  
Trophoblast Cells ◽  
Human Trophoblast ◽  
Mtor Complex 1 ◽  
Human Trophoblast Cells

We demonstrate that mTOR complex 1 modulates amino acid transport in primary human trophoblast cells by regulating Nedd4-2 mediated ubiquitination and plasma membrane trafficking of specific transporter isoforms, which may constitute a molecular mechanisms underlying abnormal human fetal growth.

scholarly journals Oleic acid stimulates system A amino acid transport in primary human trophoblast cells mediated by toll-like receptor 4

2012 ◽  
Vol 54 (3) ◽  
pp. 725-733 ◽  
Author(s):  
Susanne Lager ◽  
Francesca Gaccioli ◽  
Vanessa I. Ramirez ◽  
Helen N. Jones ◽  
Thomas Jansson ◽  
...  
Keyword(s):  
Oleic Acid ◽  
Amino Acid ◽  
Amino Acid Transport ◽  
Toll Like Receptor ◽  
Acid Transport ◽  
Trophoblast Cells ◽  
Toll Like Receptor 4 ◽  
Human Trophoblast ◽  
System A ◽  
Human Trophoblast Cells

scholarly journals Increased ubiquitination and reduced plasma membrane trafficking of placental amino acid transporter SNAT-2 in human IUGR

2015 ◽  
Vol 129 (12) ◽  
pp. 1131-1141 ◽  
Author(s):  
Yi-Yung Chen ◽  
Fredrick J. Rosario ◽  
Majida Abu Shehab ◽  
Theresa L. Powell ◽  
Madhulika B. Gupta ◽  
...  
Keyword(s):  
Plasma Membrane ◽  
Amino Acid ◽  
Ubiquitin Ligase ◽  
Membrane Trafficking ◽  
Amino Acid Transporter ◽  
Acid Transport ◽  
Mechanistic Target Of Rapamycin ◽  
Neutral Amino Acid Transporter ◽  
Acid Transporter ◽  
Mtor Signalling

Inhibition of placental mechanistic target of rapamycin (mTOR) signalling, which activates NEDD4-2 (neural precursor cell expressed developmentally down-regulated protein 4-2) ubiquitin ligase leading to increased sodium-coupled neutral amino acid transporter 2 (SNAT-2) ubiquitination and removal from the syncytiotrophoblast plasma membrane may constitute a key mechanism underlying decreased placental amino acid transport in human IUGR.

Vasoactive Intestinal Peptide induces glucose and neutral amino acid uptake through mTOR pathways in human trophoblast cells

Placenta ◽  
2019 ◽  
Vol 83 ◽  
pp. e60-e61
Author(s):  
Fatima Merech ◽  
Elizabeth Soczewski ◽  
Vanesa Hauk ◽  
Daniel Paparini ◽  
Rosanna Ramhorst ◽  
...  
Keyword(s):  
Amino Acid ◽  
Vasoactive Intestinal Peptide ◽  
Amino Acid Uptake ◽  
Neutral Amino Acid ◽  
Acid Uptake ◽  
Trophoblast Cells ◽  
Human Trophoblast ◽  
Human Trophoblast Cells
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