scholarly journals An apolipoprotein B100 mimotope prevents obesity in mice

2015 ◽  
Vol 130 (2) ◽  
pp. 105-116 ◽  
Author(s):  
Hyo Joon Kim ◽  
Hee Jong Lee ◽  
Jung Soon Choi ◽  
Jemin Han ◽  
Ji Young Kim ◽  
...  
Keyword(s):  
High Fat Diet ◽  
High Fat ◽  
Diet Induced Obesity ◽  
Antibody Titres ◽  
Lipoprotein Uptake ◽  
Obesity In Mice ◽  
Uptake And Metabolism ◽  
Vitro Data ◽  
In Vitro Data

Immunization with an ApoB100 mimotope prevents high-fat-diet-induced obesity in mice. Antibody titres parallel the weight decrements. In vitro data implicate increased lipolysis and reduced lipoprotein uptake by adipocytes, as well as increased uptake and metabolism of native lipoprotein by macrophages.

scholarly journals The Resin fromProtium heptaphyllumPrevents High-Fat Diet-Induced Obesity in Mice: Scientific Evidence and Potential Mechanisms

2015 ◽  
Vol 2015 ◽  
pp. 1-13 ◽  
Author(s):  
Karine Maria Martins Bezerra Carvalho ◽  
José Delano Barreto Marinho Filho ◽  
Tiago Sousa de Melo ◽  
Ana Jérsia Araújo ◽  
Josiane da Silva Quetz ◽  
...  
Keyword(s):  
High Fat Diet ◽  
Scientific Evidence ◽  
Net Energy ◽  
High Fat ◽  
Beneficial Effects ◽  
Proinflammatory Mediators ◽  
Glucose And Lipid Metabolism ◽  
Diet Induced Obesity ◽  
Obesity In Mice

Herbal compounds rich in triterpenes are well known to regulate glucose and lipid metabolism and to have beneficial effects on metabolic disorders. The present study investigated the antiobesity properties of resin fromProtium heptaphyllum(RPH) and the possible mechanisms in mice fed a high-fat diet (HFD) for 15 weeks. Mice treated with RPH showed decreases in body weight, net energy intake, abdominal fat accumulation, plasma glucose, amylase, lipase, triglycerides, and total cholesterol relative to their respective controls, which were RPH unfed. Additionally, RPH treatment, while significantly elevating the plasma level of ghrelin hormone, decreased the levels of insulin, leptin, and resistin. Besides, HFD-induced increases in plasma levels of proinflammatory mediators TNF-α, IL-6, and MCP-1 were significantly lowered by RPH. Furthermore,in vitrostudies revealed that RPH could significantly inhibit the lipid accumulation in 3T3-L1 adipocytes (measured by Oil-Red O staining) at concentrations up to 50 μg/mL. These findings suggest that the antiobese potential of RPH is largely due to its modulatory effects on various hormonal and enzymatic secretions related to fat and carbohydrate metabolism and to the regulation of obesity-associated inflammation.

An ursolic acid-enriched Cynomorium songarium extract attenuates high fat diet-induced obesity in mice possibly through mitochondrial uncoupling

2014 ◽  
Vol 9 ◽  
pp. 211-224 ◽  
Author(s):  
Jihang Chen ◽  
Hoi Shan Wong ◽  
Hoi Yan Leung ◽  
Pou Kuan Leong ◽  
Wing Man Chan ◽  
...  
Keyword(s):  
Ursolic Acid ◽  
High Fat Diet ◽  
High Fat ◽  
Mitochondrial Uncoupling ◽  
Diet Induced Obesity ◽  
Obesity In Mice

scholarly journals Magnesium deficiency prevents high-fat-diet-induced obesity in mice

Diabetologia ◽  
2018 ◽  
Vol 61 (9) ◽  
pp. 2030-2042 ◽  
Author(s):  
Steef Kurstjens ◽  
Janna A. van Diepen ◽  
Caro Overmars-Bos ◽  
Wynand Alkema ◽  
René J. M. Bindels ◽  
...  
Keyword(s):  
High Fat Diet ◽  
Magnesium Deficiency ◽  
High Fat ◽  
Diet Induced Obesity ◽  
Obesity In Mice

scholarly journals Euphorbia supina extract results in inhibition of high‑fat‑diet‑induced obesity in mice

2018 ◽  
Author(s):  
Sarmila Nepali ◽  
Do‑Kuk Kim ◽  
Hoon‑Yeon Lee ◽  
Hyeon‑Hui Ki ◽  
Bo‑Ram Kim ◽  
...  
Keyword(s):  
High Fat Diet ◽  
High Fat ◽  
Diet Induced Obesity ◽  
Obesity In Mice

scholarly journals Combined effects of Diospyros lotus leaf and grape stalk extract in high-fat-diet-induced obesity in mice

2019 ◽  
Vol 28 (4) ◽  
pp. 1207-1215 ◽  
Author(s):  
Denis Nchang Che ◽  
Hyun Ju Kang ◽  
Byoung Ok Cho ◽  
Jae Young Shin ◽  
Seon Il Jang
Keyword(s):  
High Fat Diet ◽  
Combined Effects ◽  
High Fat ◽  
Lotus Leaf ◽  
Diet Induced Obesity ◽  
Diospyros Lotus ◽  
Obesity In Mice

scholarly journals Glial A2B Adenosine Receptors Modulate Abnormal Tachykininergic Responses and Prevent Enteric Inflammation Associated with High Fat Diet-Induced Obesity

Cells ◽  
2020 ◽  
Vol 9 (5) ◽  
pp. 1245 ◽  
Author(s):  
Vanessa D’Antongiovanni ◽  
Laura Benvenuti ◽  
Matteo Fornai ◽  
Carolina Pellegrini ◽  
Renè van den Wijngaard ◽  
...  
Keyword(s):  
Glial Cell ◽  
High Fat Diet ◽  
Enzyme Linked Immunosorbent Assay ◽  
Standard Diet ◽  
Tlr4 Expression ◽  
High Fat ◽  
Toll Like Receptor 4 ◽  
Diet Induced Obesity ◽  
Adenosine A2b

The role played by adenosine A2B receptors (A2BRs) in the regulation of enteric glial cell (EGC) functions remains unclear. This study was aimed at investigating the involvement of A2BRs in the control of EGC functions in a model of obesity. C57BL/6 mice were fed with standard diet (SD) or high fat diet (HFD) for eight weeks. Colonic tachykininergic contractions were recorded in the presence of BAY60-6583 (A2BRs agonist), MRS1754 (A2BRs antagonist), and the gliotoxin fluorocitrate. Immunofluorescence distribution of HuC/D, S100β, and A2BRs was assessed in whole mount preparations of colonic myenteric plexus. To mimic HFD, EGCs were incubated in vitro with palmitate (PA) and lipopolysaccharide (LPS), in the absence or in the presence of A2BR ligands. Toll-like receptor 4 (TLR4) expression was assessed by Western blot analysis. Interleukin-1β (IL-1β), substance P (SP), and glial cell derived neurotrophic factor (GDNF) release were determined by enzyme-linked immunosorbent assay (ELISA) assays. MRS1754 enhanced electrically evoked tachykininergic contractions of colonic preparations from HFD mice. BAY60-6583 decreased the evoked tachykininergic contractions, with higher efficacy in HFD mice. Such effects were blunted upon incubation with fluorocitrate. In in vitro experiments on EGCs, PA and LPS increased TLR4 expression as well as IL-1β, GDNF, and SP release. Incubation with BAY60-6583 reduced TLR4 expression as well as IL-1β, GDNF, and SP release. Such effects were blunted by MRS1754. The present results suggest that A2BRs, expressed on EGCs, participate in the modulation of enteric inflammation and altered tachykininergic responses associated with obesity, thus representing a potential therapeutic target.

scholarly journals P133Atrial fibrillation vulnerability and action potential shortening in high fat diet-induced obesity in mice

2018 ◽  
Vol 114 (suppl_1) ◽  
pp. S34-S34
Author(s):  
V Galand ◽  
N Mougenot ◽  
A Coulombe ◽  
N Suffee-Mosbah ◽  
N Doisne ◽  
...  
Keyword(s):  
Action Potential ◽  
High Fat Diet ◽  
High Fat ◽  
Diet Induced Obesity ◽  
Obesity In Mice ◽  
Action Potential Shortening

scholarly journals Nrf2 Represses FGF21 During Long-Term High-Fat Diet-Induced Obesity in Mice

Diabetes ◽  
2011 ◽  
Vol 60 (10) ◽  
pp. 2465-2473 ◽  
Author(s):  
D. V. Chartoumpekis ◽  
P. G. Ziros ◽  
A. I. Psyrogiannis ◽  
A. G. Papavassiliou ◽  
V. E. Kyriazopoulou ◽  
...  
Keyword(s):  
High Fat Diet ◽  
High Fat ◽  
Diet Induced Obesity ◽  
Obesity In Mice
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