In vivo evidence of an age-related increase in ATP cost of contraction in the plantar flexor muscles

2013 ◽  
Vol 126 (8) ◽  
pp. 581-592 ◽  
Author(s):  
Gwenael Layec ◽  
Joel D. Trinity ◽  
Corey R. Hart ◽  
Seong-Eun Kim ◽  
Henderik Jonathan Groot ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Exercise Capacity ◽  
The Elderly ◽  
Plantar Flexor ◽  
Age Related ◽  
Flexor Muscles ◽  
Response To Exercise ◽  
Plantar Flexor Muscles ◽  
Related Increase

The present study reveals that impaired skeletal muscle efficiency potentially contributes to the age-related decline in exercise capacity and may explain the altered haemodynamic response to exercise in the elderly.

In Vivo Evidence Of An Age-related Increase In ATP Cost Of Contraction In The Plantar Flexor Muscles

2014 ◽  
Vol 46 ◽  
pp. 456
Author(s):  
gwenael layec ◽  
Joel D. Trinity ◽  
Corey R. Hart ◽  
Seong-Eun Kim ◽  
Henderik J. Groot ◽  
...  
Keyword(s):  
Plantar Flexor ◽  
Age Related ◽  
Flexor Muscles ◽  
Plantar Flexor Muscles ◽  
Related Increase

Chronic effects of muscle and nerve-directed stretching on tissue mechanics

2020 ◽  
Vol 129 (5) ◽  
pp. 1011-1023 ◽  
Author(s):  
Ricardo J. Andrade ◽  
Sandro R. Freitas ◽  
François Hug ◽  
Guillaume Le Sant ◽  
Lilian Lacourpaille ◽  
...  
Keyword(s):  
Mechanical Properties ◽  
Sciatic Nerve ◽  
Peripheral Nerves ◽  
Tissue Mechanics ◽  
Plantar Flexor ◽  
Chronic Effects ◽  
Flexor Muscles ◽  
Plantar Flexor Muscles

This study demonstrates that the mechanical properties of plantar flexor muscles and sciatic nerve can adapt mechanically to long-term stretching programs. Although interventions targeting muscular or nonmuscular structures are both effective at increasing maximal range of motion, the changes in tissue mechanical properties (stiffness) are specific to the structure being preferentially stretched by each program. We provide the first in vivo evidence that stiffness of peripheral nerves adapts to long-term loading stimuli using appropriate nerve-directed stretching.

scholarly journals Age-Related Changes in Twitch Properties of Plantar Flexor Muscles in Prepubertal Children

2005 ◽  
Vol 58 (5) ◽  
pp. 966-970 ◽  
Author(s):  
Jean-Francois Grosset ◽  
Isabelle Mora ◽  
Daniel Lambertz ◽  
Chantal Perot
Keyword(s):  
Plantar Flexor ◽  
Prepubertal Children ◽  
Age Related ◽  
Flexor Muscles ◽  
Plantar Flexor Muscles ◽  
Age Related Changes

Differences in age-related changes in the plantar flexor muscles and Achilles tendon in men

2006 ◽  
Vol 39 ◽  
pp. S547
Author(s):  
K. Kubo ◽  
M. Morimoto ◽  
T. Komuro ◽  
N. Tsunoda ◽  
H. Kanehisa ◽  
...  
Keyword(s):  
Achilles Tendon ◽  
Plantar Flexor ◽  
Age Related ◽  
Flexor Muscles ◽  
Plantar Flexor Muscles ◽  
Age Related Changes

Age-Related Differences in the Properties of the Plantar Flexor Muscles and Tendons

2007 ◽  
Vol 39 (3) ◽  
pp. 541-547 ◽  
Author(s):  
KEITARO KUBO ◽  
MASANORI MORIMOTO ◽  
TERUAKI KOMURO ◽  
NAOYA TSUNODA ◽  
HIROAKI KANEHISA ◽  
...  
Keyword(s):  
Plantar Flexor ◽  
Age Related ◽  
Flexor Muscles ◽  
Plantar Flexor Muscles

scholarly journals Age-related changes in collagen synthesis and degradation in rat tissues. Importance of degradation of newly synthesized collagen in regulating collagen production

1991 ◽  
Vol 276 (2) ◽  
pp. 307-313 ◽  
Author(s):  
P K Mays ◽  
R J McAnulty ◽  
J S Campa ◽  
G J Laurent
Keyword(s):  
Skeletal Muscle ◽  
Collagen Synthesis ◽  
Rat Tissues ◽  
Age Related ◽  
Developmental Growth ◽  
Cross Links ◽  
Fractional Synthesis ◽  
Synthesis And Degradation ◽  
Age Related Changes

During developmental growth, collagens are believed to be continuously deposited into an extracellular matrix which is increasingly stabilized by the formation of covalent cross-links throughout life. However, the age-related changes in rates of synthetic and degradative processes are less well understood. In the present study we measured rates of collagen synthesis in vivo using a flooding dose of unlabelled proline given with [14C]proline and determining production of hydroxy[14C]proline. Degradation of newly synthesized collagen was estimated from the amount of free hydroxy [14C]proline in tissues 30 min after injection. Collagen fractional synthesis rates ranged from about 5%/day in skeletal muscle to 20%/day in hearts of rats aged 1 month. At 15 months of age, collagen fractional synthesis rates had decreased markedly in lung and skin, but in skeletal muscle and heart, rates were unchanged. At 24 months of age, synthesis rates had decreased by at least 10-fold in all tissues, compared with rates at 1 month. The proportion of newly synthesized collagen degraded ranged from 6.4 +/- 0.4% in skin to 61.6 +/- 5.0% in heart at 1 month of age. During aging the proportion degraded increased in all tissues to maximal values at 15 months, ranging from 56 +/- 7% in skin to 96 +/- 1% in heart. These data suggest that there are marked age-related changes in rates of collagen metabolism. They also indicate that synthesis is active even in old animals, where the bulk of collagens produced are destined to be degraded.

scholarly journals Superoxide Anion Production and Bioenergetic Profile in Young and Elderly Human Primary Myoblasts

2018 ◽  
Vol 2018 ◽  
pp. 1-16 ◽  
Author(s):  
Mariangela Marrone ◽  
Rita Maria Laura La Rovere ◽  
Simone Guarnieri ◽  
Ester Sara Di Filippo ◽  
Giovanni Monaco ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Oxidative Phosphorylation ◽  
Energy Demand ◽  
The Elderly ◽  
Compensatory Mechanisms ◽  
Superoxide Anion Production ◽  
Age Related ◽  
Primary Myoblasts ◽  
Production Variability ◽  
And Function

Sarcopenia is the age-related loss of skeletal muscle mass, strength, and function. It is associated with regenerative difficulties by satellite cells, adult muscle stem cells, and alteration of oxidative management, mainly the increase in superoxide anions (O2•−). We aimed to investigate the relation between regenerative deficit in elderly and increase in O2•− production along with mitochondrial alterations. Myoblasts and myotubes from skeletal muscle of young and elderly healthy subjects (27.8 ± 6 and 72.4 ± 6.5 years old) were measured: (1) superoxide dismutase activity and protein content, (2) mitochondrial O2•− production levels, (3) O2•− production variability, and (4) mitochondrial bioenergetic profile. Compared to young myoblasts, elderly myoblasts displayed decreased SOD2 protein expression, elevated mitochondrial O2•− baseline levels, and decreased oxidative phosphorylation and glycolysis. Additionally, elderly versus young myotubes showed elevated mitochondrial O2•− levels when stressed with N-acetyl cysteine or high glucose and higher glycolysis despite showing comparable oxidative phosphorylation levels. Altogether, the elderly may have less metabolic plasticity due to the impaired mitochondrial function caused by O2•−. However, the increased energy demand related to the differentiation process appears to activate compensatory mechanisms for the partial mitochondrial dysfunction.

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