scholarly journals ACE gene insertion/deletion polymorphism modulates capillary permeability in hypertension

2006 ◽  
Vol 111 (6) ◽  
pp. 357-364 ◽  
Author(s):  
Giulia Dell'omo ◽  
Giuseppe Penno ◽  
Laura Pucci ◽  
Daniela Lucchesi ◽  
Carmen Fotino ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Essential Hypertension ◽  
Smoking Habits ◽  
Capillary Endothelium ◽  
Genetic Profile ◽  
Atherosclerotic Vascular Disease ◽  
Deletion Polymorphism ◽  
Ace Gene ◽  
Urine Albumin ◽  
Albumin Permeation

A D/D (deletion/deletion) polymorphism within the ACE (angiotensin 1-converting enzyme) gene increases the risk of microalbuminuria, a predictor of atherosclerotic vascular disease, in essential hypertension. It is unknown, however, whether this genetic profile is accompanied by disturbed macromolecular permeability of systemic capillary endothelium, possibly in the context of generalized endothelial dysfunction. In the present study, the ACE gene polymorphism was determined by PCR in 79 never-treated uncomplicated hypertensive men and 16 normotensive men as controls. Evaluation variables were TERalb (transcapillary escape rate of albumin; the 1-h decline rate of intravenous 125I-albumin, a measure of integrity of systemic capillary endothelium), albuminuria and forearm vasodilation to intra-arterial acetylcholine, an index of NO (nitric oxide)-mediated vasomotion, in addition to a series of sensitive parameters of albumin permeation (blood pressure, metabolic status and smoking habits). Analyses were done by comparing D/D homozygotes with grouped I/D (insertion/deletion) and I/I (insertion/insertion) subjects. TERalb was higher in D/D hypertensives, who had higher albuminuria, more frequent microalbuminuria and comparable forearm responsiveness to intra-arterial acetylcholine. Fasting glucose and insulin, insulin sensitivity, 24-h blood pressure, smoking habits and metabolic parameters did not differ between the two groups. TERalb and urine albumin values were positively associated in the hypertensive subjects. In conclusion, ACE D/D homozygosis, independently of several confounding factors, associates with higher TERalb in men with essential hypertension. This may reflect noxious genetic influences on systemic vascular permeability, a critical control mechanism for atherogenesis in the absence of grossly impaired NO-mediated arteriolar responsiveness. The parallel behaviour of TERalb and albuminuria suggests some shared genetically mediated determinant of renal and systemic microvascular abnormalities in hypertension.

Polymorphism insertion/deletion of the ACE gene and ambulatory blood pressure circadian variability in essential hypertension

2001 ◽  
Vol 6 (1) ◽  
pp. 27-32 ◽  
Author(s):  
Raul Julve ◽  
Felipe J. Chaves ◽  
Eduardo Rovira ◽  
Jose M. Pascual ◽  
Amparo Miralles ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Essential Hypertension ◽  
Ambulatory Blood Pressure ◽  
Ace Gene

scholarly journals Association of common medical comorbidities with early renal damage in the Chinese tropics with essential hypertension

2021 ◽  
Vol 22 (1) ◽  
Author(s):  
Yuzhuo Zhang ◽  
Ying Zhao ◽  
Chenglu Wei ◽  
Yongrong Li ◽  
Hira Aslam ◽  
...  
Keyword(s):  
Risk Factors ◽  
Blood Pressure ◽  
Essential Hypertension ◽  
Renal Damage ◽  
Binary Logistic Regression ◽  
Inverse Association ◽  
Medical Comorbidities ◽  
Logistic Regression Models ◽  
Urine Albumin ◽  
Independent Risk Factors

Abstract Background Urine albumin/creatinine ratio (UACR) is an important marker of early renal damage (ERD) caused by hypertension. Recent studies showed that blood pressure was a significant inverse association with temperature and climate. The purposes of our study were sought to explore the association of common medical comorbidities with ERD, and find independent risk factors to ERD in Chinese tropics with essential hypertension. Methods From January 2018 to December 2019, we assessed UACR in a total of 599 hypertensive Chinese Hainan patients. We defined ERD as a UACR between 30 mg/g and 300 mg/g. We analysed differences between qualitative variables using the chi-squared (χ2) test. We calculated correlations between UACR and age, hypertension duration (HD), systolic blood pressure (SBP), and diastolic blood pressure (DBP) using the Spearman’s rho test. To determine the odds ratio (OR), we evaluated binary logistic regression models. Results Among the 599 patients, 281 (46.9%) were found to have ERD. ERD and factors related to sex, body mass index (BMI), and SBP did not differ significantly (all, p>0.05). Our main findings showed that age, HD, and DBP were associated with ERD (p<0.01, respectively). Furthermore, age ≥ 65 years, HD ≥10 years, DBP ≥ 90 mmHg, SBP ≥ 160 mmHg, and diabetes differed significantly according to ERD status (p < 0.05, respectively). In multivariate analysis using stepwise regression, age (OR = 1.468), DBP (OR = 1.853), and diabetes (OR = 2.031) were significant independent predictors of ERD. The area under the receiver operating characteristic (ROC) curve was 0.677, and the sensitivity and specificity of the optimal cut-off value were 44.5 and 81.1%, respectively. Conclusions Common medical comorbidities are associated with ERD; age, DBP, and diabetes are independent risk factors for ERD in patients with essential hypertension who live in the Chinese tropics. Early monitoring of the UACR, as well as control of blood glucose and DBP, can effectively delay ERD.

scholarly journals ALBUMIN KREATININ PENDERITA HIPERTENSI HAKIKI (ESENSIAL)

2018 ◽  
Vol 14 (2) ◽  
pp. 67
Author(s):  
T. Wongso ◽  
Dewi LS ◽  
Z. Lubis
Keyword(s):  
Blood Pressure ◽  
Essential Hypertension ◽  
Renal Excretion ◽  
Diastolic Pressure ◽  
Cross Sectional ◽  
Urine Albumin Excretion ◽  
Hypertension Patient ◽  
Urine Albumin ◽  
Urine Creatinine ◽  
Strong Relation

Increasing of urine albumin excretion in hypertension patient is early sign of renal excretion disorder. Increasing of urine albuminexcretion could not detect with conventional methods, but with more sensitive methods, one of them is examined ratio of urine albuminand urine creatinine (ACR). Knowing ACR rate in essential hypertension. This research was done by cross sectional with consecutivesampling of hypertension patient with JNC VII 2003 criteria. Research used quantitative urine albumin with Albumin Tina QuantMethods draught Immunoturbidinetry. The urine creatinine was analyzed with Jaffe Methods using Roche Hitachi 902. From 25 peopleof hypertension group found ACR < 30 mg/g amount 16 people and ACR rate 30–300 mg/g amount 9 people. Mean while from 22people of non hypertension, all had ACR < 30 mg/g. In this research also found strong correlation between ACR with hypertension,diastolic and systolic blood pressure. It was found that ACR rate of hypertension group was higher than the non hypertension group. Itwas also found a strong relation between ACR with hypertension, systolic and blood diastolic pressure.

scholarly journals The insertion-deletion polymorphism of the ACE gene is associated with increased blood pressure in women at the end of pregnancy

2013 ◽  
Vol 16 (3) ◽  
pp. 623-632 ◽  
Author(s):  
Evgeny A Reshetnikov ◽  
Ludmila Y Akulova ◽  
Irina S Dobrodomova ◽  
Volodymyr Y Dvornyk ◽  
Alexey V Polonikov ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Deletion Polymorphism ◽  
Ace Gene

scholarly journals Deletion Polymorphism of ACE Gene Is Associated with Higher Blood Pressure after Hospitalization in Normotensive Subjects.

2000 ◽  
Vol 23 (3) ◽  
pp. 201-205 ◽  
Author(s):  
Kinji UEMURA ◽  
Katsuhiko KOHARA ◽  
Jun NAKURA ◽  
Tetsuro MIKI
Keyword(s):  
Blood Pressure ◽  
Deletion Polymorphism ◽  
Ace Gene ◽  
Normotensive Subjects

scholarly journals Association of ACE Gene Insertion/Deletion Polymorphism With Birth Weight, Blood Pressure Levels, and ACE Activity in Healthy Children

2012 ◽  
Vol 25 (7) ◽  
pp. 827-832 ◽  
Author(s):  
A. R. Ajala ◽  
S. S. Almeida ◽  
M. Rangel ◽  
Z. Palomino ◽  
M. W. L. Strufaldi ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Birth Weight ◽  
Healthy Children ◽  
Deletion Polymorphism ◽  
Ace Gene ◽  
Gene Insertion ◽  
Ace Activity
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