Coronary vasomotor response is related to the angiographic extent of coronary sclerosis in patients with stable angina pectoris

2004 ◽  
Vol 106 (2) ◽  
pp. 115-120 ◽  
Author(s):  
Folkert W. ASSELBERGS ◽  
Stefan H.J. MONNINK ◽  
Nic J.G.M. VEEGER ◽  
Ad J. VAN BOVEN ◽  
Paul L. VAN HAELST ◽  
...  
Keyword(s):  
Risk Factors ◽  
Angina Pectoris ◽  
Coronary Angiography ◽  
Coronary Arteries ◽  
Stable Angina ◽  
Clinical Importance ◽  
Vasomotor Response ◽  
Stable Angina Pectoris ◽  
Vasomotor Function ◽  
Coronary Vasomotor Function

Disturbed vasomotor function in coronary arteries has clinical importance in early stages of coronary artery disease (CAD), as it may contribute to the potential risk for an ischaemic coronary event. In the present study, we have investigated the relationship between coronary vasomotor function and the extent of CAD. The response to acetylcholine and nitrate infusion was assessed by quantitative coronary angiography. The extent of CAD was categorized into two groups: minor CAD (normal coronary arteries and vessel wall irregularities) and significant CAD (one-, two- and three-vessel disease). A total of 277 patients with stable angina pectoris, referred for a first diagnostic coronary angiography, were eligible for analysis (mean age 57 years, 61% male). The response to nitrate was significantly impaired in patients with significant CAD (P<0.001). On the other hand, the response to acetylcholine was not different between the two groups (P=0.12); however, a trend between the response to acetylcholine and the extent of CAD was observed in patients without a previous infarction (P=0.07), which was a significant interaction variable. Furthermore, a significant relationship between coronary vasomotor response and the number of cardiovascular risk factors was observed (P<0.05). In conclusion, in a heterogeneous group of patients, coronary vasomotor function measured by nitrate infusion was more strongly associated with the extent of CAD and the number of risk factors than the response to acetylcholine. These data suggest that, in patients with advanced atherosclerosis or multiple risk factors, the vasomotor dysfunction is not solely restricted to the endothelium.

Ttrimetyllysine and risk of new-onset atrial fibrillation in two large norwegian cohorts

2021 ◽  
Vol 28 (Supplement_1) ◽  
Author(s):  
MM Svenningsson ◽  
I Dhar ◽  
GFT Svingen ◽  
EKR Pedersen ◽  
D Nilsen ◽  
...  
Keyword(s):  
Atrial Fibrillation ◽  
Angina Pectoris ◽  
Coronary Angiography ◽  
Stable Angina ◽  
Cox Regression ◽  
Health Study ◽  
Stable Angina Pectoris ◽  
Age And Gender ◽  
And Gender ◽  
New Onset

Abstract Funding Acknowledgements Type of funding sources: None. Background/Aim Increased plasma trimetyllysine (TML), a methylated amino acid, has recently been linked to higher risk of acute myocardial infarction (AMI). TML is also a precursor of trimethylamine-N oxide (TMAO), which has been linked to increased cardiovascular risk, including that of  atrial fibrillation (AF). We investigated the association between TML and new-onset AF in two large Norwegian cohorts. Methods The primary cohort consisted of 6396 participants in the community-based Hordaland Health Study (HUSK). The validation cohort consited of 2027 patients who underwent coronary angiography due to suspected stable angina pectoris in the Western Norway Coronary Angiography Cohort (WECAC). Information on new-onset AF was obtained by linking patient data to Norwegian public health registries. Risk associations were explored by Cox regression. Results During median (25th-75th percentile) follow-up of 10.9 (10.6-11.3) and 7.0 (6.3-8.6) years, 560 (8.8%) patients in the HUSK and 210 (10.4%) in the WECAC was diagnosed with AF. In the HUSK, the age and gender adjusted HR (95 % CI) for the 4th vs. 1st plasma TML quartiles 1.84 (1.37-2.48) p &lt; 0.001. In multivariable models the association was only slightly attenuated. Correspondingsly, the age and gender adjusted HR (95% CI) for the 4th vs. 1st TML quartiles in the WECAC was 1.48 (0.96-2.27) p = 0.07. Testing for collinearity between TMAO and TML revealed variance inflation factors between 1.0-1.1 in HUSK and WECAC, thus ruling out collinearity. Conclusion Plasma TML was associated with new-onset AF among subjects from the general population, and the relationship was independent from established AF risk factors. A similar trend was also seen in patients with suspected stable angina pectoris, strengthening our findings, which motivate further studies to explore potential pathophysiological relationships between one-carbon metabolism and cardiac arrhythmias

scholarly journals High Prevalence of a Pathological Response to Acetylcholine Testing in Patients With Stable Angina Pectoris and Unobstructed Coronary Arteries

2012 ◽  
Vol 59 (7) ◽  
pp. 655-662 ◽  
Author(s):  
Peter Ong ◽  
Anastasios Athanasiadis ◽  
Gabor Borgulya ◽  
Heiko Mahrholdt ◽  
Juan Carlos Kaski ◽  
...  
Keyword(s):  
Angina Pectoris ◽  
Coronary Arteries ◽  
Stable Angina ◽  
Pathological Response ◽  
Stable Angina Pectoris ◽  
High Prevalence

Diagnostic accuracy of non-invasive 64-slice CT coronary angiography in patients with stable angina pectoris

2005 ◽  
Vol 16 (3) ◽  
pp. 575-582 ◽  
Author(s):  
Francesca Pugliese ◽  
Nico R. A. Mollet ◽  
Giuseppe Runza ◽  
Carlos van Mieghem ◽  
Willem B. Meijboom ◽  
...  
Keyword(s):  
Angina Pectoris ◽  
Coronary Angiography ◽  
Diagnostic Accuracy ◽  
Stable Angina ◽  
Ct Coronary Angiography ◽  
Stable Angina Pectoris ◽  
Non Invasive
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