Decrease of serum levels of the anti-inflammatory cytokine interleukin-10 in patients with advanced chronic heart failure

2003 ◽  
Vol 105 (1) ◽  
pp. 45-50 ◽  
Author(s):  
Christian STUMPF ◽  
Christoph LEHNER ◽  
Atilla YILMAZ ◽  
Werner G. DANIEL ◽  
Christoph D. GARLICHS
Keyword(s):  
Heart Failure ◽  
Chronic Heart Failure ◽  
Inflammatory Cytokine ◽  
Serum Levels ◽  
Interleukin 10 ◽  
Anti Inflammatory ◽  
Anti Inflammatory Cytokine

Elevation of serum levels of the anti-inflammatory cytokine interleukin-10 and decreased risk of coronary events in patients with unstable angina

2002 ◽  
Vol 144 (5) ◽  
pp. 811-817 ◽  
Author(s):  
Ignasi Anguera ◽  
Faustino Miranda-Guardiola ◽  
Xavier Bosch ◽  
Xavier Filella ◽  
Marta Sitges ◽  
...  
Keyword(s):  
Unstable Angina ◽  
Inflammatory Cytokine ◽  
Serum Levels ◽  
Interleukin 10 ◽  
Anti Inflammatory ◽  
Coronary Events ◽  
Anti Inflammatory Cytokine

scholarly journals The Prognostic Determinant of Interleukin-10 in Patients with Acute Ischemic Stroke: An Analysis from the Perspective of Disease Management

2021 ◽  
Vol 2021 ◽  
pp. 1-9
Author(s):  
Wen Sun ◽  
Shuhui Wang ◽  
Shanji Nan
Keyword(s):  
Ischemic Stroke ◽  
Acute Ischemic Stroke ◽  
Inflammatory Cytokine ◽  
Serum Levels ◽  
Interleukin 10 ◽  
Clinical Severity ◽  
Anti Inflammatory ◽  
Anti Inflammatory Cytokine

Background. In patients with ischemic stroke, the role of anti-inflammatory cytokine Interleukin-10 (IL-10) in predicting risk and outcomes is not very clear. This study is aimed at prospectively assessing the prognostic determinant value of IL-10 in patients with acute ischemic stroke in a cohort of Chinese people. Methods. In a prospective cohort study, consecutive first-ever patients with acute ischemic stroke admitted to our hospital were included from October 2019 to October 2020. The serum level of IL-10 was measured at baseline. A structured follow-up telephone interview was performed on day 90 after admission. Logistic regression analyses were used to assess the prognostic value of IL-10 to predict the poor functional outcome (defined as a modified Rankin Scale score of 3 to 6) and mortality. Results. The median age of the 236 enrolled patients was 65 years (interquartile range (IQR), 56-76), and 57.6% were male. There was a negative correlation between the National Institutes of Health Stroke Scale (NIHSS) score and IL-10 serum levels ( r   Spearman = − 0.221 , P = 0.001 ). Patients with elevated IL-10 levels (> the highest quartile = 5.24   pg / mL ; n = 79 ) were at significantly lower risk of poor functional outcomes (odds ratio (OR), 0.35; 95% confidence interval (CI), 0.19 to 0.63; P < 0.001 ) and mortality ( OR = 0.24 ; 95% CI = 0.11 –0.52; P < 0.001 ) compared with patients with IL-10 levels in the lowest three quartiles. Conclusions. Reduced serum levels of IL-10 were independently associated with both the clinical severity at admission and a poor functional prognosis in ischemic stroke patients, suggesting that the anti-inflammatory cytokine IL-10 was an important prognostic determinant.

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