Autoantibodies against oxidized low-density lipoprotein and C-reactive protein are associated with diabetes and myocardial infarction in women

2001 ◽  
Vol 101 (5) ◽  
pp. 523 ◽  
Author(s):  
Annika DOTEVALL ◽  
Johannes HULTHE ◽  
Annika ROSENGREN ◽  
Olov WIKLUND ◽  
Lars WILHELMSEN
Keyword(s):  
Myocardial Infarction ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Low Density ◽  
Oxidized Low Density Lipoprotein ◽  
C Reactive Protein ◽  
Reactive Protein

scholarly journals Oxidized Low Density Lipoprotein and High Sensitive C-Reactive Protein in Non-Diabetic, Pre-Diabetic and Diabetic Patients in the Acute Phase of the First Myocardial Infarction Treated by Primary Percutaneous Coronary Intervention / Oksidovani Lipoprotein Niske Gustine I Visokosenzitivni C-Reaktivni Protein Kod Nedijabetičara, Predijabetičara I Dijabetičara U Akutnoj Fazi Prvog Infarkta Miokarda Lečenog Primarnom Perkutanom Koronarnom Intervencijom

2015 ◽  
Vol 34 (2) ◽  
pp. 160-169 ◽  
Author(s):  
Danijela Trifunović ◽  
Sanja Stanković ◽  
Jelena Marinković ◽  
Marko Banović ◽  
Nina Đukanović ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Coronary Intervention ◽  
Low Density ◽  
Oxidized Low Density Lipoprotein ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Percutaneous Coronary ◽  
Hs Crp

Summary Background: Oxidized low density lipoprotein (ox-LDL) and high-sensitive C-reactive protein (hs-CRP) are elevated in diabetes mellitus (DM) and associated with accelerated atherosclerosis. Little is known about their dynamics in the acute phase of ST segment elevation myocardial infarction (STEMI), especially in relation to the presence of DM and pre-diabetes (pre-DM). This study aimed to analyze timedependent changes in ox-LDL and hs-CRP regarding the presence of pre-DM and DM in STEMI patients treated by primary percutaneous coronary intervention (pPCI). Methods: In 103 consecutive patients with the first anterior STEMI ox-LDL and hs-CRP were measured before pPCI, on day 2 and day 7 after pPCI. Results: Patients were classified into: non-diabetics, pre-diabetics and diabetics. In each group the maximal ox-LDL concentration was found on admission, decreased on day 2 and reached the lowest values on day 7 (p<0.001). Diabetics had the highest ox-LDL concentrations compared to pre-diabetics and non-diabetics (on admission: p=0.028, on day 2: p=0.056, on day 7: p=0.004). hs-CRP concentration rose from admission, reached its peak on day 2 and decreased on day 7, in each group (p<0.001). Significant differences in hs-CRP concentrations were found between non-diabetics and pre-diabetics on admission (p=0.018) and day 2 (p=0.026). In a multivariate analysis DM was an independent determinant of high ox-LDL concentrations. Both ox-LDL and hs-CRP significantly correlated with Killip class, left ventricular ejection fraction, NT-proBNP and peak troponin I. Conclusions: In patients with the first STEMI treated by pPCI there were significant differences in ox-LDL and hs-CRP concentrations between non-diabetics, pre-diabetics and diabetics. Ox-LDL and hs-CRP concentrations were related to heart failure parameters.

Autoantibodies against oxidized low-density lipoprotein and C-reactive protein are associated with diabetes and myocardial infarction in women

2001 ◽  
Vol 101 (5) ◽  
pp. 523-531 ◽  
Author(s):  
Annika DOTEVALL ◽  
Johannes HULTHE ◽  
Annika ROSENGREN ◽  
Olov WIKLUND ◽  
Lars WILHELMSEN
Keyword(s):  
Diabetes Mellitus ◽  
Myocardial Infarction ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Low Density ◽  
Healthy Controls ◽  
Oxidized Low Density Lipoprotein ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Antibody Titres

Women with diabetes mellitus are at high risk of myocardial infarction (MI), and it is well recognized that smoking, hypertension, hyperlipidaemia and the diabetic state itself do not fully explain this increased risk. During the last decade, growing evidence has accumulated that the immune system, with oxidized low-density lipoprotein (LDL) as a key antigen, plays an important role in the development of atherosclerosis. The aim of the present study was to explore the association between the immune response, as measured by antibody titres to malondialdehyde-treated LDL (MDA-LDL) and levels of C-reactive protein (CRP; a marker of inflammation), and diabetes mellitus and MI in women. Women (35-64 years) with diabetes (n = 18) and non-diabetic women (n = 46) who had been treated in hospital for MI were compared with diabetic women without MI (n = 35) and healthy controls (n = 70). Blood samples were collected after an overnight fast. CRP was determined with a highly sensitive immuno-enzymometric assay. IgM and IgG antibodies against MDA-LDL were analysed with a solid-phase ELISA technique. Women with diabetes but without previous MI were more similar to women with previous MI (both with and without diabetes) than to the healthy controls. Compared with healthy women, the women with diabetes and/or MI had higher IgG (P < 0.05) and lower IgM (P = 0.006) antibody titres against oxidized LDL and higher CRP levels (P < 0.001), associations that were independent of other cardiovascular risk factors. These findings might indicate a differentiated immune response against modified LDL, more pronounced inflammation and a more aggressive atherosclerotic process in women with diabetes.

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