Low-frequency heart rate variability: reproducibility in cardiac transplant recipients and normal subjects

2001 ◽  
Vol 100 (1) ◽  
pp. 43 ◽  
Author(s):  
S. W. LORD ◽  
R. R. SENIOR ◽  
M. DAS ◽  
A. M. WHITTAM ◽  
A. MURRAY ◽  
...  
2000 ◽  
Vol 100 (1) ◽  
pp. 43-46 ◽  
Author(s):  
S. W. LORD ◽  
R. R. SENIOR ◽  
M. DAS ◽  
A. M. WHITTAM ◽  
A. MURRAY ◽  
...  

Heart rate variability is a measure of autonomic nervous influence on the heart. It has been suggested that it could be used to detect autonomic reinnervation to the transplanted heart, but the reproducibility of the measurement is unknown. In the present study, 21 cardiac transplant recipients and 21 normal subjects were recruited. Three measurements of heart rate variability were performed during the day: in the morning, in the early afternoon and in the late afternoon. These tests were then repeated 1 week later and then again 1 week after that, making nine tests in all. The within-subject S.D. was 0.49 log units in normal subjects and 0.79 log units in transplant recipients. In both cases, this is about 15% of the population range. There was significant variation in heart rate variability between different times of day in both groups, and from day to day in transplant recipients. It was concluded that the reproducibility of measurements of heart rate variability is low, and that differences between measurements performed at different times of day should be interpreted with caution.


1996 ◽  
Vol 239 (5) ◽  
pp. 443-449 ◽  
Author(s):  
PEKKA KOSKINEN ◽  
JUHA VIROLAINEN ◽  
PETRI K. KOSKINEN ◽  
PEKKA HAYRY ◽  
MARKKU KUPARI

Circulation ◽  
1989 ◽  
Vol 79 (1) ◽  
pp. 76-82 ◽  
Author(s):  
K E Sands ◽  
M L Appel ◽  
L S Lilly ◽  
F J Schoen ◽  
G H Mudge ◽  
...  

Life ◽  
2021 ◽  
Vol 11 (7) ◽  
pp. 625
Author(s):  
Eric Hermand ◽  
François Lhuissier ◽  
Aurélien Pichon ◽  
Nicolas Voituron ◽  
Jean-Paul Richalet

Periodic breathing is a respiratory phenomenon frequently observed in patients with heart failure and in normal subjects sleeping at high altitude. However, until recently, periodic breathing has not been studied in wakefulness and during exercise. This review relates the latest findings describing this ventilatory disorder when a healthy subject is submitted to simultaneous physiological (exercise) and environmental (hypoxia, hyperoxia, hypercapnia) or pharmacological (acetazolamide) stimuli. Preliminary studies have unveiled fundamental physiological mechanisms related to the genesis of periodic breathing characterized by a shorter period than those observed in patients (11~12 vs. 30~60 seconds). A mathematical model of the respiratory system functioning under the aforementioned stressors corroborated these data and pointed out other parameters, such as dead space, later confirmed in further research protocols. Finally, a cardiorespiratory interdependence between ventilatory oscillations and heart rate variability in the low frequency band may partly explain the origin of the augmented sympathetic activation at exercise in hypoxia. These nonlinear instabilities highlight the intrinsic “homeodynamic” system that allows any living organism to adapt, to a certain extent, to permanent environmental and internal perturbations.


2010 ◽  
Vol 24 (2) ◽  
pp. 112-119 ◽  
Author(s):  
F. Riganello ◽  
A. Candelieri ◽  
M. Quintieri ◽  
G. Dolce

The purpose of the study was to identify significant changes in heart rate variability (an emerging descriptor of emotional conditions; HRV) concomitant to complex auditory stimuli with emotional value (music). In healthy controls, traumatic brain injured (TBI) patients, and subjects in the vegetative state (VS) the heart beat was continuously recorded while the subjects were passively listening to each of four music samples of different authorship. The heart rate (parametric and nonparametric) frequency spectra were computed and the spectra descriptors were processed by data-mining procedures. Data-mining sorted the nu_lf (normalized parameter unit of the spectrum low frequency range) as the significant descriptor by which the healthy controls, TBI patients, and VS subjects’ HRV responses to music could be clustered in classes matching those defined by the controls and TBI patients’ subjective reports. These findings promote the potential for HRV to reflect complex emotional stimuli and suggest that residual emotional reactions continue to occur in VS. HRV descriptors and data-mining appear applicable in brain function research in the absence of consciousness.


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