Common genetic variants that relate to disorders of lipid transport in Spanish subjects with premature coronary artery disease

2001 ◽  
Vol 100 (2) ◽  
pp. 183 ◽  
Author(s):  
Ll. MASANA ◽  
G. FEBRER ◽  
J. CAVANNA ◽  
M.G. BARONI ◽  
W. MARZ ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Genetic Variants ◽  
Lipid Transport ◽  
Premature Coronary Artery Disease ◽  
Common Genetic Variants ◽  
Artery Disease

scholarly journals Joint effects of common genetic variants from multiple genes and pathways on the risk of premature coronary artery disease

2010 ◽  
Vol 160 (2) ◽  
pp. 250-256.e3 ◽  
Author(s):  
Jeffrey L. Anderson ◽  
Benjamin D. Horne ◽  
Nicola J. Camp ◽  
Joseph B. Muhlestein ◽  
Paul N. Hopkins ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Genetic Variants ◽  
Premature Coronary Artery Disease ◽  
Joint Effects ◽  
Multiple Genes ◽  
Common Genetic Variants ◽  
Artery Disease

Genetic variants of PON1 , GSTM1 , GSTT1 , and locus 9p21.3, and the risk for premature coronary artery disease in Yucatan, Mexico

2021 ◽  
Author(s):  
Igrid García‐González ◽  
Gerardo Pérez‐Mendoza ◽  
Alberto Solís‐Cárdenas ◽  
Jorge Flores‐Ocampo ◽  
Luis Fernando Herrera‐Sánchez ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Genetic Variants ◽  
Premature Coronary Artery Disease ◽  
Artery Disease

scholarly journals Genetic Variants and Haplotypes in OPG Gene Are Associated with Premature Coronary Artery Disease and Traditional Cardiovascular Risk Factors in Mexican Population: The GEA Study

2020 ◽  
Vol 39 (11) ◽  
pp. 2085-2094
Author(s):  
Nonanzit Pérez-Hernández ◽  
Rosalinda Posadas-Sánchez ◽  
Gilberto Vargas-Alarcón ◽  
Benny Giovanni Cazarín-Santos ◽  
Antonio Miranda-Duarte ◽  
...  
Keyword(s):  
Risk Factors ◽  
Coronary Artery Disease ◽  
Cardiovascular Risk ◽  
Coronary Artery ◽  
Cardiovascular Risk Factors ◽  
Genetic Variants ◽  
Mexican Population ◽  
Premature Coronary Artery Disease ◽  
Artery Disease

Common genetic variants that relate to disorders of lipid transport in Spanish subjects with premature coronary artery disease

2001 ◽  
Vol 100 (2) ◽  
pp. 183-190 ◽  
Author(s):  
Ll. MASANA ◽  
G. FEBRER ◽  
J. CAVANNA ◽  
M. G. BARONI ◽  
W. MARZ ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Lipoprotein Lipase ◽  
Plasma Cholesterol ◽  
Plasma Lipid ◽  
Density Lipoprotein ◽  
Hdl Cholesterol ◽  
Lipid Transport ◽  
Premature Coronary Artery Disease ◽  
Artery Disease

Fifteen common polymorphic variants at six loci (apolipoproteins AI, B, CIII and E, hepatic lipase and lipoprotein lipase) involved in plasma lipid transport have been studied in 210 northern Spanish men, of whom 98 had proven coronary artery disease. The other 112 men were clinically free from coronary artery disease and acted as controls. The genotypes were investigated for relationships with plasma lipid and lipoprotein levels, as well as for the presence of coronary artery disease. As expected, the mean levels of plasma triacylglycerols (triglycerides) and lipoprotein (a) and the number of smokers were significantly higher in the disease group, and high-density lipoprotein (HDL)-cholesterol was significantly lower. Surprisingly, plasma cholesterol and low-density lipoprotein cholesterol were not different between the two groups. With regard to the common mutations, plasma triacylglycerol levels were related to the HindIII variants of lipoprotein lipase (P < 0.05), to the apolipoprotein CIII variant (C3175G in exon 4) and to the apolipoprotein AI XmnI polymorphisms (P < 0.05 and P < 0.02 respectively). The apolipoprotein E variants were related to plasma cholesterol (P < 0.05), HDL-cholesterol (P < 0.02), plasma triacylglycerols (P < 0.05) and the triacylglycerol/HDL ratio (P < 0.01). Only the three-codon insertion/deletion variants of the apolipoprotein B signal peptide region discriminated between the two groups with or without arterial disease (P = 0.02). The possible functional effects of these common mutations are discussed.

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