Occlusion cuff position is an important determinant of the time course and magnitude of human brachial artery flow-mediated dilation

2000 ◽  
Vol 99 (4) ◽  
pp. 261 ◽  
Author(s):  
Karen L. BERRY ◽  
R. Andrew P. SKYRME-JONES ◽  
Ian T. MEREDITH
2000 ◽  
Vol 99 (4) ◽  
pp. 261-267 ◽  
Author(s):  
Karen L. BERRY ◽  
R. Andrew P. SKYRME-JONES ◽  
Ian T. MEREDITH

Non-invasive ultrasound techniques to assess flow-mediated vasodilation (FMD) are frequently used to assess arterial endothelial vasodilator function. However, the range of normal values varies considerably, possibly due to differences in methodological factors. We sought to determine the effect of occlusion cuff position on the time course and magnitude of brachial artery blood flow and flow-mediated dilation. Twelve healthy subjects underwent measurements of forearm blood flow using venous occlusion plethysmography (VOP) before and after 5 min of susprasystolic cuff inflation, using two randomly assigned occlusion cuff positions (upper arm and forearm). An additional 16 subjects underwent two brachial ultrasound studies, using the two cuff positions, to assess the extent and time course of changes in brachial artery diameter and blood flow. Maximum increase in blood flow (peak reactive hyperaemia), measured by VOP, occurred immediately upon each cuff deflation, but was greater after upper arm compared with forearm arterial occlusion (33.1±3.1 versus 22.8±2.2 ml/min per forearm tissue, P = 0.001). Maximal brachial artery FMD was significantly greater following upper arm occlusion (9.0±1.2%, mean±S.E.M.) compared with forearm occlusion (5.9±0.7%, P = 0.01). The time course of the change in brachial artery diameter was affected differently in response to each protocol. The time to peak dilation following upper arm occlusion was delayed by 22 s compared with forearm occlusion. Occlusion cuff position is thus a powerful determinant of peak reactive hyperaemia, volume repaid and the extent and time course of brachial artery FMD. Positioning the cuff on the upper arm produces a greater FMD. These results highlight the need for comparisons between FMD studies to be made with care.


2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Yizhou Wen ◽  
Xianmin Wang ◽  
Yonghong Guo ◽  
Mei Jin ◽  
Jimei Xi ◽  
...  

AbstractCoronary artery abnormalities (CAAs) are a severe complication of Kawasaki disease (KD) that may lead to cardiovascular events. Given the evidence that brachial artery flow-mediated dilation (FMD) decreases in children after the onset of KD, we hypothesized that it could be an early marker of CAA development in the acute stage and investigated its relationship with variation in the coronary artery diameter. A total of 326 sex- and age-matched children were enrolled, including 120 with KD, 109 febrile children and 97 healthy controls. In this study, FMD was significantly decreased in the KD group compared with the febrile and healthy groups. FMD was lower in the CAA group than in the no coronary artery abnormality group. The comparison of FMD showed an obvious difference among the CAA subgroups. The FMD in the coronary aneurysm (CA) group showed a strong negative correlation with the pretreatment maximum coronary artery Z-score (preZmax). While preZmax was 2.5, the receiver operating characteristic curve indicated an optimal cutoff point of 3.44% for FMD. FMD ≤ 3.44% could be considered as a signal of coronary lesions in acute stage of KD.


2005 ◽  
Vol 25 (2) ◽  
pp. 392-398 ◽  
Author(s):  
Markus Juonala ◽  
Jorma S.A. Viikari ◽  
Mika Kähönen ◽  
Leena Taittonen ◽  
Tapani Rönnemaa ◽  
...  

2009 ◽  
Vol 107 (4) ◽  
pp. 445-453 ◽  
Author(s):  
Ryan A. Harris ◽  
Steven K. Nishiyama ◽  
D. Walter Wray ◽  
Vince Tedjasaputra ◽  
Damian M. Bailey ◽  
...  

2014 ◽  
Vol 113 (1) ◽  
pp. 162-167 ◽  
Author(s):  
Michael Shechter ◽  
Alon Shechter ◽  
Nira Koren-Morag ◽  
Micha S. Feinberg ◽  
Liran Hiersch

Author(s):  
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Júlio Augusto Gurgel Alves ◽  
Sammya Bezerra Maia E Holanda Moura ◽  
Edward Araujo Júnior ◽  
Wellington P. Martins ◽  
...  

2008 ◽  
Vol 197 (1) ◽  
pp. 212-216 ◽  
Author(s):  
Keiko Suzuki ◽  
Suh-Hang Hank Juo ◽  
Tanja Rundek ◽  
Bernadette Boden-Albala ◽  
Norbelina Disla ◽  
...  

2019 ◽  
Vol 7 (13) ◽  
Author(s):  
Hugo Gravel ◽  
Geoff B. Coombs ◽  
Parya Behzadi ◽  
Virginie Marcoux‐Clément ◽  
Hadiatou Barry ◽  
...  

2020 ◽  
Vol 19 (1) ◽  
Author(s):  
Shabnam Salimi ◽  
Jeff D. Yanosky ◽  
Dina Huang ◽  
Jessica Montressor-Lopez ◽  
Robert Vogel ◽  
...  

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