Circulating C-type natriuretic peptide is increased in orthotopic cardiac transplant recipients and associated with cardiac allograft vasculopathy

2000 ◽  
Vol 99 (5) ◽  
pp. 467
Author(s):  
Martin G. BUCKLEY ◽  
Geraint H. JENKINS ◽  
Andrew G. MITCHELL ◽  
Magdi H. YACOUB ◽  
Donald R.J. SINGER
Keyword(s):  
Natriuretic Peptide ◽  
Cardiac Allograft Vasculopathy ◽  
Cardiac Allograft ◽  
Cardiac Transplant ◽  
Transplant Recipients ◽  
Allograft Vasculopathy

Low Serum IGF-1 Is a Risk Factor for Cardiac Allograft Vasculopathy in Cardiac Transplant Recipients

2012 ◽  
Vol 93 (3) ◽  
pp. 309-313 ◽  
Author(s):  
Seyedhossein Aharinejad ◽  
Mohamed Salama ◽  
Susanne Rödler ◽  
Marek Ehrlich ◽  
Andreas Zuckermann ◽  
...  
Keyword(s):  
Risk Factor ◽  
Cardiac Allograft Vasculopathy ◽  
Cardiac Allograft ◽  
Cardiac Transplant ◽  
Transplant Recipients ◽  
Allograft Vasculopathy ◽  
Low Serum

Circulating C-type natriuretic peptide is increased in orthotopic cardiac transplant recipients and associated with cardiac allograft vasculopathy

2000 ◽  
Vol 99 (5) ◽  
pp. 467-472 ◽  
Author(s):  
Martin G. BUCKLEY ◽  
Geraint H. JENKINS ◽  
Andrew G. MITCHELL ◽  
Magdi H. YACOUB ◽  
Donald R. J. SINGER
Keyword(s):  
Heart Transplantation ◽  
Plasma Levels ◽  
Healthy Subjects ◽  
Cardiac Transplantation ◽  
Cardiac Allograft Vasculopathy ◽  
Cardiac Allograft ◽  
Cardiac Transplant ◽  
Transplant Recipients ◽  
Allograft Vasculopathy ◽  
Post Transplant

C-type natriuretic peptide (CNP) is a potent, endothelial-derived relaxant and growth-inhibitory factor. Accelerated vascular disease is an important cause of morbidity in cardiac transplant recipients, and endothelial dysfunction is now well recognized in patients with cardiovascular disease. CNP has not previously been investigated following cardiac transplantation. We therefore studied plasma levels of immunoreactive CNP in patients early and late after heart transplantation, compared with levels in healthy subjects. We measured CNP in extracted human plasma using an antibody against human CNP-(1–22). CNP levels were significantly elevated in 13 cardiac recipients 2 weeks post-transplant [2.64±0.26 pmol/l (mean±S.E.M.)] compared with those in the normal healthy subjects (0.62±0.04 pmol/l; n = 20, P < 0.001). Plasma levels of CNP were also significantly elevated in a second group of established cardiac transplant recipients (1.15±0.07 pmol/l; n = 46) studied 1–13 years post-transplant when compared with the healthy subjects (P < 0.001). In the group studied later after transplantation, CNP levels were significantly associated with systolic blood pressure (P < 0.05) and were higher in patients with angiographic post-transplant coronary artery disease (P = 0.032). In conclusion, these findings clearly demonstrate that CNP is elevated soon after cardiac transplantation and remains raised in patients even several years post-transplant. CNP may be important as a circulating or local hormone involved in vascular contractile function and in the pathophysiology of cardiac allograft vasculopathy following heart transplantation.

scholarly journals Early Inflammatory Markers Are Independent Predictors of Cardiac Allograft Vasculopathy in Heart-Transplant Recipients

PLoS ONE ◽  
2014 ◽  
Vol 9 (12) ◽  
pp. e113260 ◽  
Author(s):  
Carlos A. Labarrere ◽  
John R. Woods ◽  
James W. Hardin ◽  
Beate R. Jaeger ◽  
Marian Zembala ◽  
...  
Keyword(s):  
Heart Transplant ◽  
Inflammatory Markers ◽  
Cardiac Allograft Vasculopathy ◽  
Cardiac Allograft ◽  
Transplant Recipients ◽  
Allograft Vasculopathy ◽  
Heart Transplant Recipients
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