Influence of posture and handgrip on the QT interval in left ventricular hypertrophy and in chronic heart failure

1999 ◽  
Vol 96 (4) ◽  
pp. 403 ◽  
Author(s):  
Patrick DAVEY
Keyword(s):  
Heart Failure ◽  
Chronic Heart Failure ◽  
Left Ventricular Hypertrophy ◽  
Qt Interval ◽  
Ventricular Hypertrophy ◽  
Left Ventricular

Prolongation of the QT interval in heart failure occurs at low but not at high heart rates

2000 ◽  
Vol 98 (5) ◽  
pp. 603-610 ◽  
Author(s):  
P. P. DAVEY ◽  
C. BARLOW ◽  
G. HART
Keyword(s):  
Heart Failure ◽  
Heart Rate ◽  
Left Ventricular Hypertrophy ◽  
Qt Interval ◽  
Ventricular Hypertrophy ◽  
Left Ventricular ◽  
Qt Interval Prolongation ◽  
Qt Intervals ◽  
Ventricular Structure ◽  
And Function

Abnormal left ventricular structure and function as in, for example, left ventricular hypertrophy or chronic heart failure, is associated with sudden cardiac death and, when the ejection fraction is depressed, with prolongation of the QT interval. The dependence on heart rate of QT interval prolongation in these conditions, and the relationship of any abnormalities either to deranged autonomic nervous system function or to an adverse prognosis, has not been well studied. We therefore investigated (1) the dependence on heart rate of the QT interval, and (2) the relationship between both QT interval and the QT/heart rate slope and markers of adverse prognosis in these two conditions. The QT interval was measured at rest and during exercise in 34 subjects with heart failure, 16 subjects with left ventricular hypertrophy and 16 age-matched controls with normal left ventricular structure and function. QTc (corrected QT) intervals at rest were significantly longer in heart failure patients (471±10 ms) than in controls (421±6 ms) or in subjects with hypertrophy (420±6 ms) (P < 0.05). At peak exercise, despite the attainment of similar heart rates, the QT intervals no longer differed from each other, being 281±7 ms for controls, 296±11 ms in hypertrophy and 303±10 ms in heart failure (no significant difference). The QT/heart rate slope was significantly increased in heart failure [2.3±0.1 ms·(beats/min)-1] compared with controls [1.55±0.06 ms·(beats/min)-1] and hypertrophy [1.66±0.1 ms·(beats/min)-1] (P < 0.001). In left ventricular hypertrophy, despite animal data suggesting that QT interval prolongation should occur, no abnormalities were found in QT intervals at rest or during exercise. The QT/heart rate slope did not relate to any markers for an adverse prognosis, except that of prolongation of QT interval. Long QT intervals were associated principally with impairment of left ventricular systolic function. Our data emphasize the dynamic nature of the QT interval abnormalities found in heart failure.

scholarly journals PROGNOSTIC SIGNIFICANCE OF BLOOD MARKER OF HYPERTROPHY– CARDIOTROPHIN-1 WHEN CARRYING DIFFERENT VARIANTS OF ITS GENE IN MEN WITH ESSENTIAL HYPERTENSION

2021 ◽  
Vol 74 (2) ◽  
pp. 273-277
Author(s):  
Maryna O. Matokhniuk ◽  
Oleksandr V. Limanskiy ◽  
Olena V. Maiko ◽  
Vadym Zhebel ◽  
Oleksandra K. Shevchuk ◽  
...  
Keyword(s):  
Heart Failure ◽  
Essential Hypertension ◽  
Chronic Heart Failure ◽  
Left Ventricular Hypertrophy ◽  
Ventricular Hypertrophy ◽  
Prognostic Significance ◽  
Left Ventricular ◽  
Gene Variants ◽  
Its Gene ◽  
Blood Marker

The aim: To improve diagnosis of essential hypertension with left ventricular hypertrophy and chronic heart failure in men citizens of Podillya region in Ukraine by determining the plasma levels of cardiotrophin-1 in patients with different CT-1 gene variants. Materials and methods: A total of 70 men with no signs of cardiovascular disease and 100 patients with essential hypertension were examined. Among those, 50 participants had hypertension and left ventricular hypertrophy. Other 50 patients had hypertension complicated by chronic heart failure. Results: It was established that in patients with essential hypertension the frequency of the pool of genotypes GA + AA is higher than the genotype GG (p <0.05). Plasma CT-1 levels ≥ 122,895 pg / ml can be used for early diagnosis left ventricular hypertrophy, and the cut-off level is ≥ 303.81 pg / ml (sensitivity 85.7%, specificity 92%) for screening diagnosis of essential hypertension complications in the form of chronic heart failure. Conclusions: In patients with essential hypertension of varying severity, the GA+АА genotypes of CT-1 gene was found to be dominant. They had higher levels of plasma concentration CT-1. The threshold levels of CT-1 for screening diagnosis of essential hypertension with hypertrophy and chronic heart failure in males (who were residents of the Podillya region of Ukraine) were evaluated.

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