Factors determining cardiac hypertrophy in hypertensive patients with or without peripheral vascular disease

1998 ◽  
Vol 95 (3) ◽  
pp. 261 ◽  
Author(s):  
M. BRAHIMI ◽  
B.I. LEVY ◽  
M.E. SAFAR ◽  
H. DABIRÉ
Keyword(s):  
Cardiac Hypertrophy ◽  
Vascular Disease ◽  
Peripheral Vascular Disease ◽  
Peripheral Vascular ◽  
Hypertensive Patients

Factors determining cardiac hypertrophy in hypertensive patients with or without peripheral vascular disease

1998 ◽  
Vol 95 (3) ◽  
pp. 261-267 ◽  
Author(s):  
M. BRAHIMI ◽  
B. I. LEVY ◽  
M. E. SAFAR ◽  
H. DABIRÉ
Keyword(s):  
Mean Arterial Pressure ◽  
Arterial Pressure ◽  
Cardiac Hypertrophy ◽  
Vascular Disease ◽  
Peripheral Vascular Disease ◽  
Pulse Pressure ◽  
Systolic Pressure ◽  
Cardiac Mass ◽  
Peripheral Vascular ◽  
Hypertensive Patients

1.Coronary ischaemic disease and congestive heart failure are the principal causes of mortality in patients with peripheral vascular disease. Whether cardiac hypertrophy is present and even more pronounced in peripheral vascular disease than in other populations has never been explored. 2.Twenty-five hypertensive patients were investigated, 11 without and 14 with peripheral vascular disease, matched for age, sex, mean arterial pressure and antihypertensive drug treatment. Cardiac mass was determined using echocardiography together with measurement of systemic blood pressure, ratio between ankle systolic pressure (ASP) and brachial systolic pressure (BSP), and standard biochemical parameters including natriuresis per 24 ;h. 3.At the same mean arterial pressure, patients with peripheral vascular disease had a significantly higher cardiac mass (157±12 versus 116±6 ;g/m2; P< 0.01), pulse pressure (81±5 versus 55±4 ;mmHg; P< 0.01) and natriuresis (180±17 versus 144±6 ;mmol/24 h; P< 0.01) than controls. Using univariate correlations, cardiac mass was positively associated with pulse pressure, mean arterial pressure and natriuresis, and negatively with the ASP/BSP ratio. On the basis of multivariate regression analysis, only natriuresis was positively correlated to cardiac mass. 4.Patients with peripheral vascular disease develop a higher degree of cardiac hypertrophy in comparison with hypertensive subjects with the same level of mean arterial pressure. Sodium intake rather than mechanical factors seems to be the major modulating factor which influences the degree of cardiac hypertrophy.

Tests for Platelet Changes, Acute Phase Reactants and Serum Lipids in Diabetes mellitus and Peripheral Vascular Disease

1982 ◽  
Vol 48 (03) ◽  
pp. 289-293 ◽  
Author(s):  
B A van Oost ◽  
B F E Veldhuyzen ◽  
H C van Houwelingen ◽  
A P M Timmermans ◽  
J J Sixma
Keyword(s):  
Diabetes Mellitus ◽  
Vascular Disease ◽  
Peripheral Vascular Disease ◽  
Acute Phase ◽  
Serum Lipids ◽  
Diabetic Patients ◽  
Peripheral Vascular ◽  
Acute Phase Reactants ◽  
Control Subjects ◽  
And Control

SummaryPlatelets tests, acute phase reactants and serum lipids were measured in patients with diabetes mellitus and patients with peripheral vascular disease. Patients frequently had abnormal platelet tests and significantly increased acute phase reactants and serum lipids, compared to young healthy control subjects. These differences were compared with multidiscriminant analysis. Patients could be separated in part from the control subjects with variables derived from the measurement of acute phase proteins and serum lipids. Platelet test results improved the separation between diabetics and control subjects, but not between patients with peripheral vascular disease and control subjects. Diabetic patients with severe retinopathy frequently had evidence of platelet activation. They also had increased acute phase reactants and serum lipids compared to diabetics with absent or nonproliferative retinopathy. In patients with peripheral vascular disease, only the fibrinogen concentration was related to the degree of vessel damage by arteriography.

Surgical Therapy for Coronary Artery Disease Among Patients With Combined Coronary Artery and Peripheral Vascular Disease

Circulation ◽  
1995 ◽  
Vol 91 (1) ◽  
pp. 46-53 ◽  
Author(s):  
Charanjit S. Rihal ◽  
Kim A. Eagle ◽  
Mary C. Mickel ◽  
Eric D. Foster ◽  
George Sopko ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Vascular Disease ◽  
Peripheral Vascular Disease ◽  
Surgical Therapy ◽  
Peripheral Vascular ◽  
Artery Disease
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