Nitric oxide synthase activity is increased in relation to the severity of liver dysfunction

1998 ◽  
Vol 95 (3) ◽  
pp. 355 ◽  
Author(s):  
Helen F. GALLEY ◽  
David COOMANSINGH ◽  
Nigel R. WEBSTER ◽  
Peter W. BRUNT
Keyword(s):  
Nitric Oxide ◽  
Nitric Oxide Synthase ◽  
Liver Dysfunction ◽  
Oxide Synthase ◽  
Nitric Oxide Synthase Activity

Nitric oxide synthase activity is increased in relation to the severity of liver dysfunction

1998 ◽  
Vol 95 (3) ◽  
pp. 355-359 ◽  
Author(s):  
Helen F. GALLEY ◽  
David COOMANSINGH ◽  
Nigel R. WEBSTER ◽  
Peter W. BRUNT
Keyword(s):  
Nitric Oxide ◽  
Blood Pressure ◽  
Liver Disease ◽  
Nitric Oxide Synthase ◽  
Liver Dysfunction ◽  
Pearson Correlation ◽  
Cell Protein ◽  
Biochemical Indices ◽  
Oxide Synthase ◽  
Nitric Oxide Synthase Activity

1.Nitric oxide is a potent vasodilator which plays a major role in the control of blood pressure. The hyperdynamic circulation of cirrhosis has been linked to nitric oxide. 2.We measured neutrophil nitric oxide synthase activity in relation to the level of hepatic dysfunction in patients with liver disease of varying aetiology and severity. 3.Neutrophils were isolated from 21 patients (7 Child-Pugh score A, 6 grade B and 8 grade C) aged 28–76 (median 49) years. Nitric oxide synthase activity was measured using the conversion of oxyhaemoglobin to methaemoglobin by nitric oxide and expressed in terms of cell protein. Blood pressure and biochemical indices were recorded. Data were assessed using Kruskal–Wallis one-way analysis of variance, Mann–Whitney U-test or Pearson correlation as appropriate. 4.Systolic, mean arterial and diastolic blood pressures decreased with increasing hepatic damage (P = 0.031, P = 0.01 and P = 0.038 respectively). Nitric oxide synthase activity increased with the degree of liver dysfunction (P = 0.033) and was highest in patients with Child-Pugh score C. Systolic blood pressure correlated with nitric oxide synthase activity in patients with Child-Pugh score C (P = 0.029). 5.Our results show that nitric oxide synthase activity increases with increasing Child-Pugh score and is associated with the development of systemic hypotension. These data may support the involvement of nitric oxide in the haemodynamic disturbances seen in liver disease.

Effect of KH-305 on the Nitric Oxide Synthase Activity and Erectile Dysfunction in Young Rats

2007 ◽  
Vol 36 (3) ◽  
pp. 305-310 ◽  
Author(s):  
Eun-Jeong Lee ◽  
Hee-Seok Kim ◽  
Byoung-Chul Kim ◽  
Sung-Wan Hwang ◽  
Sung-Yeoun Hwang
Keyword(s):  
Nitric Oxide ◽  
Erectile Dysfunction ◽  
Nitric Oxide Synthase ◽  
Young Rats ◽  
Oxide Synthase ◽  
Nitric Oxide Synthase Activity

Inhibition of Nitric Oxide Synthase Activity by Zn2+ Ion

Biochemistry ◽  
1995 ◽  
Vol 34 (46) ◽  
pp. 15091-15095 ◽  
Author(s):  
Anthony Persechini ◽  
Kirk McMillan ◽  
Bettie Sue Siler Masters
Keyword(s):  
Nitric Oxide ◽  
Nitric Oxide Synthase ◽  
Oxide Synthase ◽  
Nitric Oxide Synthase Activity

scholarly journals Time Course of Inducible Nitric Oxide Synthase Activity Following Endotoxin Administration in Dogs

Nitric Oxide ◽  
2001 ◽  
Vol 5 (2) ◽  
pp. 208-211 ◽  
Author(s):  
Jean-Charles Preiser ◽  
Haibo Zhang ◽  
Bernard Vray ◽  
Andreas Hrabak ◽  
Jean-Louis Vincent
Keyword(s):  
Nitric Oxide ◽  
Nitric Oxide Synthase ◽  
Inducible Nitric Oxide Synthase ◽  
Time Course ◽  
Endotoxin Administration ◽  
Oxide Synthase ◽  
Nitric Oxide Synthase Activity ◽  
Inducible Nitric Oxide

Neuroprotective Effect of Chuk-Me-Sun-Dan on NMDA- and AMPA-Evoked Nitric Oxide Synthase Activity in Mouse Brain

2005 ◽  
Vol 27 (3) ◽  
pp. 499-514 ◽  
Author(s):  
Byung-Soo Koo ◽  
Eun-Gyu Choi ◽  
Jae-Bok Park ◽  
Chang-Ho Cho ◽  
Kang-Hyun Chung ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Nitric Oxide Synthase ◽  
Mouse Brain ◽  
Neuroprotective Effect ◽  
Oxide Synthase ◽  
Nitric Oxide Synthase Activity

scholarly journals Ceruloplasmin potentiates nitric oxide synthase activity and cytokine secretion in activated microglia

2014 ◽  
Vol 11 (1) ◽  
Author(s):  
Massimo Lazzaro ◽  
Barbara Bettegazzi ◽  
Marco Barbariga ◽  
Franca Codazzi ◽  
Daniele Zacchetti ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Nitric Oxide Synthase ◽  
Cytokine Secretion ◽  
Activated Microglia ◽  
Oxide Synthase ◽  
Nitric Oxide Synthase Activity
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