Genetic Risk Factors for Severe Ulcerative Colitis Requiring Surgery — the Role of Innate Immunogenetics

2004 ◽  
Vol 106 (s50) ◽  
pp. 12P-12P
Author(s):  
DPB McGovern ◽  
T Ahmad ◽  
K Negoro ◽  
DA van Heel ◽  
DP Jewell
Keyword(s):  
Risk Factors ◽  
Ulcerative Colitis ◽  
Genetic Risk ◽  
Genetic Risk Factors ◽  
Severe Ulcerative Colitis

scholarly journals Cross-disorder analysis of schizophrenia and 19 immune-mediated diseases identifies shared genetic risk

2019 ◽  
Vol 28 (20) ◽  
pp. 3498-3513 ◽  
Author(s):  
Jennie G Pouget ◽  
Buhm Han ◽  
Yang Wu ◽  
Emmanuel Mignot ◽  
Hanna M Ollila ◽  
...  
Keyword(s):  
Risk Factors ◽  
Ulcerative Colitis ◽  
Crohn’S Disease ◽  
Crohn's Disease ◽  
Genetic Risk ◽  
Genetic Risk Factors ◽  
Phenotypic Correlation ◽  
Biliary Cirrhosis ◽  
Genome Wide ◽  
Shared Genetic

Abstract Many immune diseases occur at different rates among people with schizophrenia compared to the general population. Here, we evaluated whether this phenomenon might be explained by shared genetic risk factors. We used data from large genome-wide association studies to compare the genetic architecture of schizophrenia to 19 immune diseases. First, we evaluated the association with schizophrenia of 581 variants previously reported to be associated with immune diseases at genome-wide significance. We identified five variants with potentially pleiotropic effects. While colocalization analyses were inconclusive, functional characterization of these variants provided the strongest evidence for a model in which genetic variation at rs1734907 modulates risk of schizophrenia and Crohn’s disease via altered methylation and expression of EPHB4—a gene whose protein product guides the migration of neuronal axons in the brain and the migration of lymphocytes towards infected cells in the immune system. Next, we investigated genome-wide sharing of common variants between schizophrenia and immune diseases using cross-trait LD score regression. Of the 11 immune diseases with available genome-wide summary statistics, we observed genetic correlation between six immune diseases and schizophrenia: inflammatory bowel disease (rg = 0.12 ± 0.03, P = 2.49 × 10−4), Crohn’s disease (rg = 0.097 ± 0.06, P = 3.27 × 10−3), ulcerative colitis (rg = 0.11 ± 0.04, P = 4.05 × 10–3), primary biliary cirrhosis (rg = 0.13 ± 0.05, P = 3.98 × 10−3), psoriasis (rg = 0.18 ± 0.07, P = 7.78 × 10–3) and systemic lupus erythematosus (rg = 0.13 ± 0.05, P = 3.76 × 10–3). With the exception of ulcerative colitis, the degree and direction of these genetic correlations were consistent with the expected phenotypic correlation based on epidemiological data. Our findings suggest shared genetic risk factors contribute to the epidemiological association of certain immune diseases and schizophrenia.

scholarly journals Role of non-Genetic Risk Factors in Exacerbating Alcohol-related organ damage

Alcohol ◽  
2020 ◽  
Vol 87 ◽  
pp. 63-72
Author(s):  
Natalia A. Osna ◽  
Rakesh Bhatia ◽  
Christopher Thompson ◽  
Surinder K. Batra ◽  
Sushil Kumar ◽  
...  
Keyword(s):  
Risk Factors ◽  
Genetic Risk ◽  
Genetic Risk Factors ◽  
Organ Damage

835 Genetic Risk Factors for Clostridium difficile Infection in Ulcerative Colitis

2013 ◽  
Vol 144 (5) ◽  
pp. S-148
Author(s):  
Ashwin N. Ananthakrishnan ◽  
Emily Oxford ◽  
Deanna D. Nguyen ◽  
Jenny Sauk ◽  
Vijay Yajnik ◽  
...  
Keyword(s):  
Risk Factors ◽  
Ulcerative Colitis ◽  
Clostridium Difficile ◽  
Clostridium Difficile Infection ◽  
Genetic Risk ◽  
Genetic Risk Factors

scholarly journals Genetic risk factors forClostridium difficileinfection in ulcerative colitis

2013 ◽  
Vol 38 (5) ◽  
pp. 522-530 ◽  
Author(s):  
A. N. Ananthakrishnan ◽  
E. C. Oxford ◽  
D. D. Nguyen ◽  
J. Sauk ◽  
V. Yajnik ◽  
...  
Keyword(s):  
Risk Factors ◽  
Ulcerative Colitis ◽  
Genetic Risk ◽  
Genetic Risk Factors

Childhood Porencephaly: Role of Genetic Risk Factors in Familial Trombophilia

1999 ◽  
pp. 310-317
Author(s):  
H. Vielhaber ◽  
O. Debus ◽  
G. Kurlemann ◽  
R. Sträter ◽  
U. Nowak-Göttl
Keyword(s):  
Risk Factors ◽  
Genetic Risk ◽  
Genetic Risk Factors

Genetic Risk Factors for Arterial Thrombosis and Inflammation

Hematology ◽  
2005 ◽  
Vol 2005 (1) ◽  
pp. 442-444 ◽  
Author(s):  
David Ginsburg
Keyword(s):  
Risk Factors ◽  
Genetic Risk ◽  
Arterial Thrombosis ◽  
Rapid Development ◽  
Genetic Risk Factors ◽  
Developed Countries ◽  
Inflammatory Factor ◽  
Current State ◽  
Molecular Pathophysiology

Abstract Arterial thrombosis is a central pathologic mechanism contributing to myocardial infarction and stroke, together the leading causes of death in developed countries. This article reviews the current state of knowledge concerning the role of inherited variation in hemostatic and inflammatory factor genes in determining the risk of arterial thrombosis/ischemic heart disease. Despite considerable progress in identifying important genetic risk factors underlying predisposition to venous thrombosis, the genetic factors contributing to the risk for arterial thrombosis remain largely unknown. However, the rapid development of powerful new genomic resources should facilitate considerably more sophisticated analyses, leading to novel insight into the molecular pathophysiology of this important set of human diseases.

scholarly journals Puzzling role of genetic risk factors in human longevity: “risk alleles” as pro-longevity variants

2015 ◽  
Vol 17 (1) ◽  
pp. 109-127 ◽  
Author(s):  
Svetlana Ukraintseva ◽  
Anatoliy Yashin ◽  
Konstantin Arbeev ◽  
Alexander Kulminski ◽  
Igor Akushevich ◽  
...  
Keyword(s):  
Risk Factors ◽  
Genetic Risk ◽  
Genetic Risk Factors ◽  
Human Longevity ◽  
Longevity Risk ◽  
Risk Alleles
Sign in / Sign up

Export Citation Format

Share Document