Determination of age-related increases in large artery stiffness by digital pulse contour analysis

2002 ◽  
Vol 103 (4) ◽  
pp. 371-377 ◽  
Author(s):  
S.C. MILLASSEAU ◽  
R.P. KELLY ◽  
J.M. RITTER ◽  
P.J. CHOWIENCZYK
Keyword(s):  
Glyceryl Trinitrate ◽  
Pulse Contour Analysis ◽  
Pulse Contour ◽  
Applanation Tonometry ◽  
Large Artery ◽  
Contour Analysis ◽  
Arterial Blood ◽  
Age Related ◽  
Digital Pulse ◽  
Artery Stiffness

The stiffness of the aorta can be determined by measuring carotid–femoral pulse wave velocity (PWVcf). PWV may also influence the contour of the peripheral pulse, suggesting that contour analysis might be used to assess large artery stiffness. An index of large artery stiffness (SIDVP) derived from the digital volume pulse (DVP) measured by transmission of IR light (photoplethysmography) was examined. SIDVP was obtained from subject height and from the time delay between direct and reflected waves in the DVP. The timing of these components of the DVP is determined by PWV in the aorta and large arteries. SIDVP was, therefore, expected to provide a measure of stiffness similar to PWV. SIDVP was compared with PWVcf obtained by applanation tonometry in 87 asymptomatic subjects (21–68 years; 29 women). The reproducibility of SIDVP and PWVcf and the response of SIDVP to glyceryl trinitrate were assessed in subsets of subjects. The mean within-subject coefficient of variation of SIDVP, for measurements at weekly intervals, was 9.6%. SIDVP was correlated with PWVcf (r = 0.65, P<0.0001). SIDVP and PWVcf were each independently correlated with age and mean arterial blood pressure (MAP) with similar regression coefficients: SIDVP = 0.63+0.086×age+0.042×MAP (r = 0.69, P<0.0001); PWVcf = 0.76+0.080×age+0.053×MAP (r = 0.71, P<0.0001). Administration of glyceryl trinitrate (3, 30 and 300 μg/min intravenous; each dose for 15 min) in nine healthy men produced similar changes in SIDVP and PWVcf. Thus contour analysis of the DVP provides a simple, reproducible, non-invasive measure of large artery stiffness.

Interpretation of Noninvasive and Invasive Information

2017 ◽  
Author(s):  
Borzoo Farhang ◽  
Erik P Anderson ◽  
Mark P Hamlin
Keyword(s):  
Critically Ill ◽  
Hemodynamic Monitoring ◽  
Critically Ill Patients ◽  
Pulse Contour Analysis ◽  
Pulse Contour ◽  
Response To Therapy ◽  
Contour Analysis ◽  
Central Venous ◽  
Arterial Blood ◽  
Pulmonary Arterial

Traditional, static measures of resuscitation, such as vital signs, central venous pressure, and pulmonary arterial pressure, provide momentary glimpses evolving hemodynamic states. In patients with shock, these measures of resuscitation are poor indicators of response to therapy. As a result, dynamic assessments of cardiovascular status are now used in critically ill patients to facilitate resuscitation. Some of these approaches focus on fluid responsiveness. These assessments allow care to be tailored to each patient’s response to interventions. An evolving aspect of hemodynamic monitoring is evaluation of the adequacy of tissue perfusion and oxygen delivery. In this review, we consider the use of arterial, central venous, and pulmonary arterial blood pressure monitoring; echocardiography; transesophageal Doppler technology; pulse contour analysis; bioimpedance and bioreactance; and partial rebreathing monitoring modalities to assess hemodynamic status in critically ill patients.  This review contains 22 figures, 5 tables, and 38 references. Key words: echocardiography, esophageal Doppler technology, invasive and noninvasive hemodynamic monitoring, pulse contour analysis, shock 

scholarly journals Age-Related Abnormalities in Arterial Compliance Identified by Pressure Pulse Contour Analysis

Hypertension ◽  
1999 ◽  
Vol 33 (6) ◽  
pp. 1392-1398 ◽  
Author(s):  
Gary E. McVeigh ◽  
Christopher W. Bratteli ◽  
Dennis J. Morgan ◽  
Cheryl M. Alinder ◽  
Stephen P. Glasser ◽  
...  
Keyword(s):  
Pressure Pulse ◽  
Arterial Compliance ◽  
Pulse Contour Analysis ◽  
Pulse Contour ◽  
Contour Analysis ◽  
Age Related

Assessment of arterial stiffness in type 1 diabetes using digital pulse contour analysis: Is it a reliable method?

2015 ◽  
Vol 53 (3) ◽  
pp. 477-482 ◽  
Author(s):  
Alessandra S. de M. Matheus ◽  
Bárbara Pereira Pires ◽  
Eduardo Tibiriçá ◽  
Aline Tiemi Kano Silva ◽  
Marília B. Gomes
Keyword(s):  
Type 1 Diabetes ◽  
Arterial Stiffness ◽  
Reliable Method ◽  
Pulse Contour Analysis ◽  
Pulse Contour ◽  
Contour Analysis ◽  
Digital Pulse

Comparison of beta2-adrenergic and hyperemia-induced arterial vasodilation assessed by digital pulse contour analysis

2019 ◽  
Vol 88 (1) ◽  
pp. 7-11
Author(s):  
Andrzej Wykretowicz ◽  
Karolina Adamska ◽  
Przemysław Guzik ◽  
Marcin Zwanzig ◽  
Mateusz Dziarmaga ◽  
...  
Keyword(s):  
Pulse Contour Analysis ◽  
Pulse Contour ◽  
Contour Analysis ◽  
Significant Drop ◽  
Reflection Index ◽  
Digital Pulse ◽  
Significant Difference ◽  
Induced Changes ◽  
Volume Pulse ◽  
Digital Volume Pulse

Introduction. The Reflection Index (RIDVP) derived from digital volume pulse (DVP) analysis has proved to be useful in the assessment of endothelium‑dependent vasodilation induced by albuterol. Little is known of the effect of shear‑stress‑induced vasorelaxation on RIDVP.Material and Methods. Thirty three healthy volunteers (22 females, 11 males, mean age 57 yrs) were recruited. Assessment of endothelium‑dependent vasorelaxation was performed by the analysis of digital volume pulse after albuterol challenge or locally‑induced hyperemia. Results. he hyperemia‑induced vasodilation led to a significant decrease of RIDVP in comparison with the values obtained at rest (∆RIHyper 69 ± 2 % vs 64 ± 2, p < 0.0001). Similarly albuterol administration resulted in a significant drop in RIDVP (∆RIAlb 71 ± 2 % vs 67 ± 2 %, p < 0.0001). There was no significant difference between ∆RIHyper and ∆RIAlb (5.2 ± 0.8 % vs 4.6 ± 1.0 %, p = 0.61). We observed a significant correlation between the small vessel reaction in response to albuterol or hyperemia (r = 0.52, p = 0.01).Conclusions. Our study demonstrated that hyperemia‑induced changes in the Reflexion Index derived from the digital volume pulse are similar to those observed after albuterol‑challenge and both are correlated.

scholarly journals Cardiac output by pulse contour analysis does not match the increase measured by rebreathing during human spaceflight

2017 ◽  
Vol 123 (5) ◽  
pp. 1145-1149 ◽  
Author(s):  
Richard L. Hughson ◽  
Sean D. Peterson ◽  
Nicholas J. Yee ◽  
Danielle K. Greaves
Keyword(s):  
Cardiac Output ◽  
Stroke Volume ◽  
Cardiac Function ◽  
Pulse Contour Analysis ◽  
Pulse Contour ◽  
Alternative Methods ◽  
Contour Analysis ◽  
Windkessel Model ◽  
Human Spaceflight ◽  
Arterial Blood

Pulse contour analysis of the noninvasive finger arterial pressure waveform provides a convenient means to estimate cardiac output (Q̇). The method has been compared with standard methods under a range of conditions but never before during spaceflight. We compared pulse contour analysis with the Modelflow algorithm to estimates of Q̇ obtained by rebreathing during preflight baseline testing and during the final month of long-duration spaceflight in nine healthy male astronauts. By Modelflow analysis, stroke volume was greater in supine baseline than seated baseline or inflight. Heart rate was reduced in supine baseline so that there were no differences in Q̇ by Modelflow estimate between the supine (7.02 ± 1.31 l/min, means ± SD), seated (6.60 ± 1.95 l/min), or inflight (5.91 ± 1.15 l/min) conditions. In contrast, rebreathing estimates of Q̇ increased from seated baseline (4.76 ± 0.67 l/min) to inflight (7.00 ± 1.39 l/min, significant interaction effect of method and spaceflight, P < 0.001). Pulse contour analysis utilizes a three-element Windkessel model that incorporates parameters dependent on aortic pressure-area relationships that are assumed to represent the entire circulation. We propose that a large increase in vascular compliance in the splanchnic circulation invalidates the model under conditions of spaceflight. Future spaceflight research measuring cardiac function needs to consider this important limitation for assessing absolute values of Q̇ and stroke volume. NEW & NOTEWORTHY Noninvasive assessment of cardiac function during human spaceflight is an important tool to monitor astronaut health. This study demonstrated that pulse contour analysis of finger arterial blood pressure to estimate cardiac output failed to track the 46% increase measured by a rebreathing method. These results strongly suggest that alternative methods not dependent on pulse contour analysis are required to track cardiac function in spaceflight.

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