The Role of Regulatory T Cells in Rheumatoid Arthritis

2002 ◽  
Vol 103 (s47) ◽  
pp. 32P-32P
Author(s):  
CA Lawson ◽  
F Ponchel ◽  
AW Boylston ◽  
P Emery ◽  
JD Isaacs
Keyword(s):  
Rheumatoid Arthritis ◽  
T Cells ◽  
Regulatory T Cells

scholarly journals Compromised Function of Regulatory T Cells in Rheumatoid Arthritis and Reversal by Anti-TNFα Therapy

2004 ◽  
Vol 200 (3) ◽  
pp. 277-285 ◽  
Author(s):  
Michael R. Ehrenstein ◽  
Jamie G. Evans ◽  
Animesh Singh ◽  
Samantha Moore ◽  
Gary Warnes ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
T Cells ◽  
Regulatory T Cells ◽  
Significant Rise ◽  
Activated T Cells ◽  
Reactive Protein ◽  
Suppressive Phenotype ◽  
Factor Α

Regulatory T cells have been clearly implicated in the control of disease in murine models of autoimmunity. The paucity of data regarding the role of these lymphocytes in human autoimmune disease has prompted us to examine their function in patients with rheumatoid arthritis (RA). Regulatory (CD4+CD25+) T cells isolated from patients with active RA displayed an anergic phenotype upon stimulation with anti-CD3 and anti-CD28 antibodies, and suppressed the proliferation of effector T cells in vitro. However, they were unable to suppress proinflammatory cytokine secretion from activated T cells and monocytes, or to convey a suppressive phenotype to effector CD4+CD25− T cells. Treatment with antitumor necrosis factor α (TNFα; Infliximab) restored the capacity of regulatory T cells to inhibit cytokine production and to convey a suppressive phenotype to “conventional” T cells. Furthermore, anti-TNFα treatment led to a significant rise in the number of peripheral blood regulatory T cells in RA patients responding to this treatment, which correlated with a reduction in C reactive protein. These data are the first to demonstrate that regulatory T cells are functionally compromised in RA, and indicate that modulation of regulatory T cells by anti-TNFα therapy may be a further mechanism by which this disease is ameliorated.

The role of miR-155 in regulatory T cells and rheumatoid arthritis

2013 ◽  
Vol 148 (1) ◽  
pp. 56-65 ◽  
Author(s):  
D. Spoerl ◽  
I. Duroux-Richard ◽  
P. Louis-Plence ◽  
C. Jorgensen
Keyword(s):  
Rheumatoid Arthritis ◽  
T Cells ◽  
Regulatory T Cells

scholarly journals Role of regulatory T cells in rheumatoid arthritis: facts and hypothesis

2010 ◽  
Vol 1 (1) ◽  
pp. 45-51 ◽  
Author(s):  
Alessia Alunno ◽  
Elena Bartoloni ◽  
Giuseppe Nocentini ◽  
Onelia Bistoni ◽  
Simona Ronchetti ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
T Cells ◽  
Regulatory T Cells

scholarly journals The Role of Different Subsets of Regulatory T Cells in Immunopathogenesis of Rheumatoid Arthritis

Arthritis ◽  
2012 ◽  
Vol 2012 ◽  
pp. 1-16 ◽  
Author(s):  
Maryam Gol-Ara ◽  
Farhad Jadidi-Niaragh ◽  
Reza Sadria ◽  
Gholamreza Azizi ◽  
Abbas Mirshafiey
Keyword(s):  
Rheumatoid Arthritis ◽  
T Cells ◽  
Regulatory T Cells ◽  
Joint Inflammation ◽  
Frequency Function ◽  
Systemic Inflammatory Disease ◽  
Progression Of Disease ◽  
Cartilage Erosion ◽  
And Function

Rheumatoid arthritis (RA) is a common autoimmune disease and a systemic inflammatory disease which is characterized by chronic joint inflammation and variable degrees of bone and cartilage erosion and hyperplasia of synovial tissues. Considering the role of autoreactive T cells (particularly Th1 and Th17 cells) in pathophysiology of RA, it might be assumed that the regulatory T cells (Tregs) will be able to control the initiation and progression of disease. The frequency, function, and properties of various subsets of Tregs including natural Tregs (nTregs), IL-10-producing type 1 Tregs (Tr1 cells), TGF-β-producing Th3 cells, CD8+ Tregs, and NKT regulatory cells have been investigated in various studies associated with RA and collagen-induced arthritis (CIA) as experimental model of this disease. In this paper, we intend to submit the comprehensive information about the immunobiology of various subsets of Tregs and their roles and function in immunopathophysiology of RA and its animal model, CIA.

scholarly journals The role of CD4+CD25+ regulatory T cells in patients with Rheumatoid Arthritis

2006 ◽  
Vol 29 (1) ◽  
pp. 37-42 ◽  
Author(s):  
Rumi MINAMI ◽  
Kouko SAKAI ◽  
Tomoya MIYAMURA ◽  
Masahiro YAMAMOTO ◽  
Eiichi SUEMATSU
Keyword(s):  
Rheumatoid Arthritis ◽  
T Cells ◽  
Regulatory T Cells

Quantification and phenotype of regulatory T cells in rheumatoid arthritis according to Disease Activity Score-28

Autoimmunity ◽  
2009 ◽  
pp. 1-1
Author(s):  
Jose Miguel Sempere-Ortells ◽  
Vicente Perez-Garcia ◽  
Gema Marin-Alberca ◽  
Alejandra Peris-Pertusa ◽  
Jose Miguel Benito ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
T Cells ◽  
Regulatory T Cells ◽  
Disease Activity ◽  
Disease Activity Score ◽  
Activity Score
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