Correlation of the adipocyte-derived protein adiponectin with insulin resistance index and serum high-density lipoprotein-cholesterol, independent of body mass index, in the Japanese population

2002 ◽  
Vol 103 (2) ◽  
pp. 137-142 ◽  
Author(s):  
Yukihiro YAMAMOTO ◽  
Hiroshi HIROSE ◽  
Ikuo SAITO ◽  
Motowo TOMITA ◽  
Matsuo TANIYAMA ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Blood Pressure ◽  
Uric Acid ◽  
Adiponectin Level ◽  
Density Lipoprotein ◽  
Resistance Index ◽  
Hdl Cholesterol ◽  
Serum Adiponectin ◽  
Serum Adiponectin Level ◽  
Insulin Resistance Index

Adiponectin, which is secreted specifically by adipose tissue, has been shown to act as an anti-atherosclerotic protein by direct effects on endothelial cells. Clinical studies have shown that adiponectin levels are lower in individuals with obesity, diabetes and coronary artery disease. The present study investigated relationships between serum adiponectin levels and body mass index (BMI), blood pressure, insulin resistance index, lipid profile, uric acid and high-sensitivity C-reactive protein levels in a large number of Japanese subjects not taking any medication for metabolic disease and without severe illness (705 men and 262 women; age 30–65 years; BMI 22.5±2.9kg/m2). The serum adiponectin concentration was measured by ELISA, without a protein-denaturing step. The insulin resistance index was assessed by homoeostasis model assessment (HOMA-IR). The serum concentration of adiponectin in women (13.5±7.9μg/ml) was significantly higher than that in men (7.2±4.6μg/ml). The serum adiponectin level was negatively correlated with BMI, systolic blood pressure, diastolic blood pressure, fasting plasma glucose, insulin, HOMA-IR, total cholesterol, triacylglycerols, low-density lipoprotein (LDL)-cholesterol and uric acid, and positively correlated with high-density lipoprotein (HDL)-cholesterol. The correlations between serum adiponectin level and insulin, HOMA-IR, triacylglycerols, HDL-cholesterol, LDL-cholesterol and uric acid were significant even after adjustment for age, sex and BMI. Stepwise multiple regression analysis revealed that HDL-cholesterol, sex, BMI and HOMA-IR were independently correlated with the serum adiponectin level (R2 = 0.377). These findings suggest that the serum adiponectin level is negatively correlated with HOMA-IR and positively correlated with HDL-cholesterol, independent of age, sex and BMI, in the Japanese population.

scholarly journals Adiponectin, an Adipocyte-Derived Protein, Predicts Future Insulin Resistance: Two-Year Follow-Up Study in Japanese Population

2004 ◽  
Vol 89 (1) ◽  
pp. 87-90 ◽  
Author(s):  
Yukihiro Yamamoto ◽  
Hiroshi Hirose ◽  
Ikuo Saito ◽  
Kanako Nishikai ◽  
Takao Saruta
Keyword(s):  
Insulin Resistance ◽  
Body Weight ◽  
Lipid Profile ◽  
Adiponectin Level ◽  
Serum Insulin ◽  
Resistance Index ◽  
Serum Adiponectin ◽  
Model Assessment ◽  
Homeostasis Model Assessment ◽  
Insulin Resistance Index

It has been reported that the serum adiponectin level was negatively correlated with body mass index (BMI), insulin resistance index, and triglycerides and was positively correlated with high-density lipoprotein cholesterol in several cross-sectional studies. However, the causal relationship has not been elucidated. We investigated whether the baseline adiponectin level could predict subsequent changes in insulin resistance, lipid profile, or body weight in a 2-yr longitudinal study. This study included 590 male Japanese subjects, aged 30–65 yr, who received annual health checkups in both 2000 and 2002. Blood pressure, heart rate, and anthropometric and metabolic parameters, including serum insulin and adiponectin levels, were determined. The insulin resistance index was calculated based on homeostasis model assessment. Baseline adiponectin level was not correlated with the subsequent change in lipid profile or BMI in 2 yr after adjustment for each baseline value. However, the baseline adiponectin level was negatively correlated with subsequent changes in insulin and insulin resistance index based on homeostasis model assessment, even after adjustment for change in BMI (r = −0.162 and r = −0.140, respectively). These findings suggest that the serum adiponectin concentration predicts subsequent changes in insulin resistance, but not in lipid profile or body weight.

scholarly journals Insulin Resistance Associated with Plasma Xanthine Oxidoreductase Activity Independent of Visceral Adiposity and Adiponectin Level: MedCity21 Health Examination Registry

2019 ◽  
Vol 2019 ◽  
pp. 1-9
Author(s):  
Masafumi Kurajoh ◽  
Shinya Fukumoto ◽  
Takayo Murase ◽  
Takashi Nakamura ◽  
Takuma Ishihara ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Uric Acid ◽  
Visceral Fat ◽  
Acid Production ◽  
Adiponectin Level ◽  
Visceral Adiposity ◽  
Serum Adiponectin ◽  
Health Examination ◽  
Xanthine Oxidoreductase ◽  
Serum Adiponectin Level

Background. Higher levels of uric acid production have been reported in individuals with visceral fat obesity, and obesity is known to enhance xanthine oxidoreductase (XOR) activity, although the precise mechanism remains unclear. We investigated the associations of visceral fat area (VFA), serum adiponectin level, and insulin resistance with plasma XOR activity using our novel highly sensitive assay based on [13C2,15N2] xanthine and liquid chromatography/triple quadrupole mass spectrometry. Methods. This cross-sectional study included 193 subjects (92 males and 101 females) registered in the MedCity21 health examination registry. Plasma XOR activity, serum adiponectin level, and VFA obtained by computed tomography were measured, and insulin resistance was determined based on the homeostasis model assessment (HOMA-IR) index. Results. The mean values for VFA, log HOMA-IR, and log plasma XOR activity were 76.8 ± 45.8 cm2, 0.14 ± 0.30, and 1.50 ± 0.44 pmol/h/mL, respectively. Multiple regression analysis showed that HOMA-IR was significantly (p=0.020) associated with plasma XOR activity independent of other factors, including VFA and adiponectin level, as well as age, sex, alcohol drinking habit, smoking habit, alanine transaminase, HbA1c, and eGFR. The “sex∗HOMA−IR” interaction was not significant (p=0.89), indicating that sex difference does not have an effect on the relationship between HOMA-IR and plasma XOR activity. Conclusions. Our results indicate that insulin resistance is associated with plasma XOR activity and that relationship is independent of visceral adiposity and adiponectin level, suggesting that the development of insulin resistance resulting from increased visceral adiposity and/or reduced serum adiponectin contributes to increased uric acid production by stimulating XOR activity.

Serum uric acid is associated with metabolic risk factors for cardiovascular disease in the Uygur population

2009 ◽  
Vol 34 (6) ◽  
pp. 1032-1039 ◽  
Author(s):  
Nan F. Li ◽  
Hong M. Wang ◽  
Jin Yang ◽  
Ling Zhou ◽  
Xiao G. Yao ◽  
...  
Keyword(s):  
Risk Factors ◽  
Insulin Resistance ◽  
Blood Pressure ◽  
Uric Acid ◽  
Serum Uric Acid ◽  
Fasting Blood Glucose ◽  
Density Lipoprotein ◽  
Resistance Index ◽  
Lipoprotein Cholesterol ◽  
Model Assessment

The prevalence of hyperuricemia is low in Uygurs, who have a high prevalence of cardiovascular risk factors such as hypertension, overweight–obesity, dyslipidemia, hyperglycemia, and insulin resistance (IR). This study sought to investigate the relationships between serum uric acid (UA) and these risk factors in this population. A cross-sectional study was conducted in Uygurs (859 males, 1268 females) aged 20 to 70 years. Demographic data, systolic blood pressure (SBP), diastolic blood pressure (DBP), body mass index (BMI), and fasting and postprandial blood were obtained, and biological measurements were determined. The mean of BMI, SBP, DBP, total cholesterol, high-density lipoprotein cholesterol (HDL-c), low-density lipoprotein cholesterol (LDL-c), triglycerides, fasting blood glucose, fasting insulin, and homeostasis model assessment insulin resistance index (HOMA-IR), and the prevalence of hypertension, IR, hyperglycemia, overweight–obesity, hypercholesteremia, hyper-LDL-c, and hypertriglyceridemia increased with UA but the prevalence of hypo-HDL-c decreased (p < 0.05). Logistic regression analysis showed that the odds ratios for IR, overweight–obesity, hypercholesteremia, hyper-LDL-c, and hypertriglyceridemia against the lowest UA group increased but decreased for hypo-HDL-c (p < 0.05). The UA in the hypo-HDL-c group was lower than that of the controls; the prevalence of hypo-HDL-c in hyperuricemia subjects was lower than in those with normal UA (p < 0.05). But the opposite results were observed between overweight–obesity, hyperglycemia, IR, hypercholesteremia, hypertriglyceridemia, and hyper-LDL-c and correspondence controls, respectively (p < 0.05). In Uygur, elevated UA is associated with overweight–obesity, hypercholesteremia, hyper-LDL-c, hypertriglyceridemia, hyperglycemia, and IR. The HDL-c level significantly increases with UA, whereas the prevalence of hypo-HDL-c decreases. Further studies are needed to clarify why UA is positively correlated to HDL-c.

scholarly journals Effect of a weight loss program on serum adiponectin and insulin resistance among overweight and obese premenopausal females

2020 ◽  
Vol 95 (1) ◽  
Author(s):  
Walaa H. Foula ◽  
Rana H. Emara ◽  
Mona K. Eldeeb ◽  
Samiha A. Mokhtar ◽  
Fikrat A. El-Sahn
Keyword(s):  
Public Health ◽  
Insulin Resistance ◽  
Weight Loss ◽  
Adiponectin Level ◽  
Normal Weight ◽  
Weight Loss Program ◽  
Serum Adiponectin ◽  
Health Clinic ◽  
Serum Adiponectin Level ◽  
Health Crisis

Abstract Background Obesity has emerged as a public health crisis in many populations including Egypt. Adipose tissue produces a number of adipokines, one of them is adiponectin which has attracted much attention because of its antidiabetic and antiatherogenic effects. Objective To determine the effect of a weight loss program on serum adiponectin level and insulin resistance among overweight and obese adult premenopausal females. Study design A pre-postintervention study was carried out among 95 premenopausal overweight and obese females (body mass index ≥ 25 kg/m2) aged 20 to 40 years at the integrated health clinic affiliated to the High Institute of Public Health, Alexandria, Egypt, from February 2016 to February 2017. All participants underwent a weight loss program based on a reduced calorie balanced diet and advised to increase their physical activity. Dietary instructions and follow-up were done weekly throughout 16 weeks. Blood samples were collected to investigate serum adiponectin level and insulin resistance at the beginning and the end of the intervention. Results After 16 weeks, a significant decrease in body weight by 9.7% was associated with a significant increase in serum adiponectin from 13.3 ± 4.9 μg/ml to 18.5 ± 5.6 μg/ml. Both fasting insulin and insulin resistance had decreased significantly by 13.6% and 13.7%, respectively. Conclusion A weight reduction program depending on a reduced calorie diet for 16 weeks was associated with a significant increase in total adiponectin level and reduction in insulin resistance. An emphasis on the importance of keeping normal weight through nutritional education and the promotion of healthy diets is recommended to reduce the risk of occurrence of insulin resistance, type 2 diabetes, and cardiovascular diseases.

scholarly journals Associations among Lifestyle Status, Serum Adiponectin Level and Insulin Resistance

2004 ◽  
Vol 43 (6) ◽  
pp. 453-457 ◽  
Author(s):  
Hirokazu YOKOYAMA ◽  
Hiroshi HIROSE ◽  
Hideki OHGO ◽  
Ikuo SAITO
Keyword(s):  
Insulin Resistance ◽  
Adiponectin Level ◽  
Serum Adiponectin ◽  
Serum Adiponectin Level

scholarly journals Type 2 diabetes mellitus is associated with lower serum adiponectin level in Bangladeshi population

Mediscope ◽  
2015 ◽  
Vol 2 (2) ◽  
pp. 16-21
Author(s):  
SN Eva ◽  
GM Mollah ◽  
DK Sunyal ◽  
R Zinnat
Keyword(s):  
Diabetes Mellitus ◽  
Insulin Resistance ◽  
Adiponectin Level ◽  
Serum Insulin ◽  
Serum Adiponectin ◽  
Serum Adiponectin Level ◽  
Lower Serum ◽  
Control Subjects ◽  
Bangladeshi Population

The  aim  of  the  observational  case  control  study  was  to  find  out  the  association  of  type  2  diabetes  mellitus  (T2DM)  with  serum  adiponectin  level  in  Bangladeshi  population.  This  was  conducted  in  the  Biomedical  Research  Group,  Research  Division,  Bangladesh  Institute  of  Research and Rehabilitation in Diabetes, Endocrine and Metabolic Disorders (BIRDEM), Dhaka,  Bangladesh.  Sixty six T2DM subjects and seventy four healthy control subjects were included.  Diabetes  was  diagnosed  and  classified  as  per  World  Health  Organization  criteria.  Serum  adiponectin was measured by Enzyme Linked Immunosorbent Assay (ELISA) method. Serum  glucose  was  measured  by  glucose-oxidase  method;  serum  insulin  was  measured  by  chemiluminescence- based ELISA technique. The insulin secretory capacity (HOMA%B), insulin  sensitivity  (HOMA%S)  &  insulin  resistance  (HOMA-IR)  were  assayed  by  homeostasis  model  assessment method. Statistical analysis was performed using SPSS Windows version 11.5. The  median  (range)  fasting  serum  insulin  of  control  and T2DM subjects  were  14.7  (1.9-45.9)  and  18.1 (4.1-42.8), respectively. The median (range) serum adiponectin (?g/ml) of the control and  T2DM  subjects  were  8.7  (0.8-16.0)  and  6.2  (1.1-22.4).  The  serum  adiponectin  of  T2DM  was  significantly lower than the control subjects (p < 0.001). The median (range) HOMA%B values  of control and T2DM subjects were 160.1 (33.4-493.4) and 100.5 (17.7-349.3), respectively. The  median  HOMA%B  of  T2DM  subjects  was  significantly  lower  than  the  control  subjects  (p  <  0.001).  The  median  (range)  HOMA%S  values  of  control  and  T2DM  subjects  were  44.2  (9.8-339.4)  and  32.8  (14.3-154.7),  respectively.  The  median  HOMA%S  of  T2DM  group  was  significantly lower than the control subjects (p < 0.05). The median (range) HOMA-IR of control  and T2DM subjects were 3.5 (0.5-11.4) and 5.8 (1.0-28.3), respectively. The median HOMA-IR  of T2DM subjects was significantly higher than the control subjects (p < 0.001). The results of  the  study  suggest  that  T2DM  subjects  have  both  insulin  secretory  defects,  insulin  resistance  and associated with lower serum adiponectin level in Bangladeshi population.Mediscope Vol. 2, No. 2: July 2015, Pages 16-21

scholarly journals Fetuin-A and Its Relation to Metabolic Syndrome and Fatty Liver Disease in Obese Children Before and After Weight Loss

2008 ◽  
Vol 93 (11) ◽  
pp. 4479-4485 ◽  
Author(s):  
Thomas Reinehr ◽  
Christian L. Roth
Keyword(s):  
Insulin Resistance ◽  
Blood Pressure ◽  
Metabolic Syndrome ◽  
Weight Loss ◽  
Fatty Liver Disease ◽  
Weight Status ◽  
Resistance Index ◽  
Obese Children ◽  
Fetuin A ◽  
Insulin Resistance Index

Context: There are very limited data available concerning the relationships between fetuin-A, weight status, nonalcoholic fatty liver disease (NAFLD), and features of the metabolic syndrome (MetS) in obese humans, and especially in children. Objective: Our objective was to study the longitudinal relationships between fetuin-A, NAFLD, and MetS in obese children. Design: This was a 1-yr longitudinal follow-up study. Setting: This study was performed in primary care. Patients: A total of 36 obese and 14 lean children was included in the study. Intervention: An outpatient 1-yr intervention program based on exercise, behavior, and nutrition therapy was performed. Main Outcome Measures: Changes of weight status (sd score-body mass index), waist circumference, fetuin-A, blood pressure, lipids, transaminases, insulin resistance index homeostasis model assessment (HOMA), and prevalence of NAFLD (defined by liver ultrasound) were calculated. Results: The 12 obese children with NAFLD had significantly higher fetuin-A levels (0.35 ± 0.07 g/liter) than the 24 obese children without NAFLD (0.29 ± 0.06 g/liter) and the 14 normal weight children (0.29 ± 0.05 g/liter). Fetuin-A levels were independent of age, pubertal stage, and gender. Fetuin-A correlated significantly to systolic (r = 0.50) and diastolic blood pressure (r = 0.41), insulin resistance index HOMA (r = 0.28), and high-density lipoprotein-cholesterol (r = −0.31). Changes of fetuin-A correlated significantly to changes of insulin resistance index HOMA (r = 0.34), systolic (r = 0.31) and diastolic blood pressure (r = 0.37), and waist circumferences (r = 0.36). Substantial weight loss in 21 children led to a significant decrease of fetuin-A and the prevalence of NAFLD in contrast to the 15 children without substantial weight loss. Conclusions: Fetuin-A levels were higher in children with NAFLD, and were related to insulin resistance and to features of the MetS in both cross-sectional and longitudinal analyses. Therefore, fetuin-A might be a new promising link between obesity and its comorbidities.

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