Angiopoietin-1 Promotes Trophoblast Migration and Angiopoietin-2 Stimulates Trophoblast Proliferation and Release of Nitric Oxide during Placental Development

2001 ◽  
Vol 100 (s44) ◽  
pp. 19P-20P
Author(s):  
B. Bussolati ◽  
J. Perkins ◽  
M. Shams ◽  
M. Rhaman ◽  
S. Nijjar ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Placental Development ◽  
Angiopoietin 2 ◽  
Trophoblast Migration ◽  
Angiopoietin 1

scholarly journals Stage-dependent angiopoietin-Tie2 and nitric oxide signaling of erythrocytes in response to surgical trauma in head and neck cancer

2020 ◽  
Author(s):  
Hsiang-Ling Wu ◽  
You-Hsiang Chu ◽  
Ying-Hsuan Tai ◽  
Mei-Yung Tsou ◽  
Cheng-Hsien Wu ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Head And Neck Cancer ◽  
Head And Neck ◽  
Surgical Resection ◽  
Erythrocyte Membrane ◽  
Tumor Resection ◽  
Surgical Trauma ◽  
Nitric Oxide Signaling ◽  
Angiopoietin 2 ◽  
Angiopoietin 1

Abstract Background: Angiopoietin-Tie2 and nitric oxide pathway is crucial in tumor angiogenesis and closely correlates with tumor development, growth, and metastasis. This study aimed to investigate the angiopoietin-Tie2 and nitric oxide signaling of erythrocyte membrane in response to surgical trauma in head and neck cancer.Methods: We prospectively enrolled the patients with histology-proven head and neck squamous cell carcinoma undergoing surgical resection of primary tumors at the medical center between August and November 2019. We measured the preoperative and postoperative levels of angiopoietin-1, angiopoietin-2 in plasma using enzyme-linked immunosorbent assays, nitric oxide in plasma using nitrate/nitrite colorimetric assays, and Tie2 phosphorylation in erythrocyte membrane using Western blotting. Results: The plasma angiopoietin-1 was down-regulated from median 971.3 pg/mL (interquartile range [IQR]: 532.1 – 1569.3) to 417.9 (IQR: 270.5 – 597.3) after tumor resection (p=0.0020). Conversely, the plasma angiopoietin-2 was enhanced from 1173.6 pg/mL (IQR: 977.7 – 1450.2) to 2353.7 (IQR: 1352.4 – 2954.3) after surgery (p=0.0021), with a concomitant increase in plasma nitric oxide level from 7.73 μM (IQR: 5.39 – 10.06) to 10.50 (IQR: 7.65 – 14.18) after surgical resection (p=0.0093). Subgroup analyses further showed the angiopoietin-Tie2 and nitric oxide signaling was significant only in stage III and IV cancer.Conclusions: The dynamic change of angiopoietin-Tie2 signaling in erythrocyte membrane along with the enhanced nitric oxide in plasma after tumor resection suggests erythrocytes play a significant role in modulating surgery-induced angiogenesis, which may provide a novel marker for cancer surveillance and control.

scholarly journals Angiopoietin-1 and Angiopoietin-2 Activate Trophoblast Tie-2 to Promote Growth and Migration during Placental Development

2000 ◽  
Vol 156 (6) ◽  
pp. 2185-2199 ◽  
Author(s):  
Caroline Dunk ◽  
Munjiba Shams ◽  
Sarbjit Nijjar ◽  
Mabub Rhaman ◽  
Yan Qiu ◽  
...  
Keyword(s):  
Placental Development ◽  
And Migration ◽  
Angiopoietin 2 ◽  
Angiopoietin 1

scholarly journals Angiopoietin-Tie2 and nitric oxide signaling of erythrocytes in response to surgical trauma in head and neck cancer

2020 ◽  
Author(s):  
Hsiang-Ling Wu ◽  
You-Hsiang Chu ◽  
Ying-Hsuan Tai ◽  
Mei-Yung Tsou ◽  
Cheng-Hsien Wu ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Head And Neck ◽  
Surgical Resection ◽  
Erythrocyte Membrane ◽  
Tumor Resection ◽  
Surgical Trauma ◽  
Primary Tumors ◽  
Nitric Oxide Signaling ◽  
Angiopoietin 2 ◽  
Angiopoietin 1

Abstract Background Angiopoietin-Tie2 and nitric oxide pathway is crucial in tumor angiogenesis and closely correlates with tumor development, growth, and metastasis. This study aimed to investigate the angiopoietin-Tie2 and nitric oxide signaling of erythrocyte membrane in response to surgical trauma in head and neck cancer.Methods We prospectively enrolled the patients with histology-proven head and neck squamous cell carcinoma undergoing surgical resection of primary tumors at the medical center between August and November 2019. We measured the preoperative and postoperative levels of angiopoietin-1, angiopoietin-2 in plasma using enzyme-linked immunosorbent assays, nitric oxide in plasma using nitrate/nitrite colorimetric assays, and Tie2 phosphorylation in erythrocyte membrane using Western blotting. Results The plasma angiopoietin-1 was down-regulated from median 971.3 pg/mL (interquartile range [IQR]: 532.1 – 1569.3) to 417.9 (IQR: 270.5 – 597.3) after tumor resection ( p =0.0020). Conversely, the plasma angiopoietin-2 was enhanced from 1173.6 pg/mL (IQR: 977.7 – 1450.2) to 2353.7 (IQR: 1352.4 – 2954.3) after surgery ( p =0.0021), with a concomitant increase in plasma nitric oxide level from 7.73 μM (IQR: 5.39 – 10.06) to 10.50 (IQR: 7.65 – 14.18) after surgical resection ( p =0.0093). Subgroup analyses further showed the angiopoietin-Tie2 and nitric oxide signaling was significant only in stage III and IV cancer.Conclusions The dynamic change of angiopoietin-Tie2 signaling in erythrocyte membrane along with the enhanced nitric oxide in plasma after tumor resection suggests erythrocytes play a significant role in modulating surgery-induced angiogenesis, which may provide a novel marker for cancer surveillance and control.

Angiopoietin-1 and angiopoietin-2 mRNA expression of single murine blastocysts and the murine endometrium

2004 ◽  
Vol 82 ◽  
pp. S113-S114
Author(s):  
A.P. Hess ◽  
J. Hirchenhain ◽  
A. Schanz ◽  
L.C. Giudice ◽  
Y.Q. Su ◽  
...  
Keyword(s):  
Mrna Expression ◽  
Angiopoietin 2 ◽  
Angiopoietin 1

Angiopoietin 1 and angiopoietin 2 in follicular fluid of women undergoing a long protocol

2011 ◽  
Vol 96 (6) ◽  
pp. 1378-1383 ◽  
Author(s):  
Akemi Nishigaki ◽  
Hidetaka Okada ◽  
Tomoko Tsuzuki ◽  
Hisayuu Cho ◽  
Katsuhiko Yasuda ◽  
...  
Keyword(s):  
Follicular Fluid ◽  
Angiopoietin 2 ◽  
Angiopoietin 1 ◽  
Long Protocol

Angiopoietin-1, Angiopoietin-2, and Periostin Levels in Children with Recurrent Wheeze

2018 ◽  
Vol 31 (4) ◽  
pp. 230-235 ◽  
Author(s):  
Burcu Tahire Koksal ◽  
Beril Ozdemir Aydın ◽  
Agah Tekindal ◽  
Ozlem Yılmaz Ozbek
Keyword(s):  
Recurrent Wheeze ◽  
Angiopoietin 2 ◽  
Angiopoietin 1
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