Cardiovascular Autonomic Testing in Adolescents with Type I (Insulin-Dependent) Diabetes Mellitus: An 18-Month Follow-up Study

1998 ◽  
Vol 94 (6) ◽  
pp. 615-621 ◽  
Author(s):  
Andrea Scaramuzza ◽  
Fabrizio Salvucci ◽  
Stefano Leuzzi ◽  
Alberto Radaelli ◽  
Giuseppe d'Annunzio ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Metabolic Control ◽  
High Frequency ◽  
Baroreflex Sensitivity ◽  
Type I Diabetes ◽  
Insulin Dependent Diabetes Mellitus ◽  
Dependent Diabetes Mellitus ◽  
Cardiovascular Reflexes ◽  
Type I

1. Autonomic abnormalities are frequent in adult patients with diabetes mellitus and progress slowly; little is known about frequency and progression of autonomic abnormalities in childhood. 2. To assess whether autonomic abnormalities are already present in childhood, we evaluated the cardiovascular reflexes, the spectral analysis of spontaneous fluctuations in RR interval and blood pressure (low- and high-frequency), and the baroreflex sensitivity at rest, and after vagal (controlled breathing) and sympathetic activation (tilting) in 25 adolescents with Type I diabetes mellitus, aged 10–17 years, at baseline and after 18 months follow-up, and in 20 age- and sex-matched controls. 3. Cardiovascular reflexes were similar in both patients and controls. Similar significant changes in percentage low- and high-frequency (P < 0.005) from rest to tilting and to control breathing were observed in both patients and controls. The baroreflex sensitivity was also similar in patients and controls. Mild and non-systematic correlations were observed between autonomic tests and disease duration or metabolic control. After 18 months follow-up no changes were observed in any of the measured variables. Correlations with metabolic control remained unchanged. 4. These results indicate a substantial stability of cardiovascular autonomic function in childhood diabetes, and suggest that autonomic abnormalities are likely to develop at an older age.

Celiac disease and type I (Insulin-Dependent) diabetes mellitus in childhood: Follow-up study

1996 ◽  
Vol 10 (3) ◽  
pp. 154-159 ◽  
Author(s):  
Renata Lorini ◽  
M. Serenella Scotta ◽  
Luigia Cortona ◽  
M. Antonietta Avanzini ◽  
Letizia Vitali ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Celiac Disease ◽  
Insulin Dependent Diabetes Mellitus ◽  
Insulin Dependent Diabetes ◽  
Dependent Diabetes Mellitus ◽  
Type I ◽  
Follow Up Study ◽  
Insulin Dependent

scholarly journals Mechanisms of membranoreceptor function disturbances in pregnant patients with insulin-dependent diabetes mellitus

1994 ◽  
Vol 40 (4) ◽  
pp. 4-7 ◽  
Author(s):  
N P Mikaelyan ◽  
Yu. A. Knyazev ◽  
A. G. Maxina ◽  
V. A. Petrukhin
Keyword(s):  
Diabetes Mellitus ◽  
Type I Diabetes ◽  
Glucose Consumption ◽  
Insulin Dependent Diabetes Mellitus ◽  
Insulin Binding ◽  
Insulin Dependent Diabetes ◽  
Dependent Diabetes Mellitus ◽  
Type I ◽  
Functional Changes ◽  
Insulin Dependent

Studies of membranoreceptor system in patients with insulin-dependent diabetes mellitus revealed that insulin resistance in pregnant patients with type I diabetes is caused by disordered cellular sensitivity to threshold physiological and submaximal insulin doses, whereas the maximal doses of the hormone normalize glucose consumption by the cells. High insulin doses intensify lipid peroxidation, normalize the status of membranous proteins, reduce the number of thiol groups, reduce AOA level in membranes, and, hence, reduce membranous capacity to bind active peroxide radicals. Structural and functional changes in red cell membranes are associated with reduced affinity of insulin receptors, reduction in the number of insulin-binding sites in membranes, this disordering intracellular effects of insulin.

scholarly journals ADAPTIVE CAPACITY IMPAIRMENT IN CHILDREN WITH INSULIN-DEPENDENT DIABETES MELLITUS AS SHOWN BY TIME INTERVAL ASSESSMENT

2021 ◽  
Vol 14 (5) ◽  
pp. 112-116
Author(s):  
YURI V. BYKOV ◽  
◽  
VLADIMIR A. BATURIN ◽  
Keyword(s):  
Diabetes Mellitus ◽  
Type I Diabetes ◽  
Insulin Dependent Diabetes Mellitus ◽  
Insulin Dependent Diabetes ◽  
Dependent Diabetes Mellitus ◽  
Control Group ◽  
Study Group ◽  
Type I ◽  
Level Of Consciousness ◽  
Insulin Dependent

Aim. The aim of the study was to diagnose and study the severity of impaired adaptive capacity in children with insulin-dependent diabetes mellitus using the method of assessment of time intervals. Material and methods. The study included 54 adolescents, aged 14 to 18 years. 27 adolescents with type I diabetes mellitus, who were urgently hospitalized in the intensive care unit in a serious condition, constituted the study group, the other 27 adolescents who were hospitalized for planned surgical intervention constituted the control group (conditionally healthy children). The diagnosis of type I diabetes mellitus was confirmed by clinical and laboratory data (hyperglycemia, ketoacidosis, impaired level of consciousness (deafening-sore). Study protocol: psychophysiological testing in adolescents was performed using the original «Rhythm» program, which presented patients with a reference sequence of sound signals and pauses between them, after which the patients played back the sound sequence using a personal computer. Adolescents in the study group were tested after diabetic ketoacidosis had subsided, glycemia had stabilized, and the level of consciousness had normalized (3–5 days after admission). The control group was tested upon admission to thehospital for planned treatment. Significance of the total index of deviations from the specified reference was determined using Student’s t-criterion. Results and discussion. Significant adaptation disorders were detected both in the study group and in the control group. However, in children with diabetes mellitus these disorders were more pronounced due to a greater shortening of the total duration of the cycle, as well as a greater aggregate index of deviations from the duration of set signals and pauses as compared to the «reference standard». Conclusion. The findings support the hypothesis that impaired adaptation mechanisms as a manifestation of desynchronization of biological rhythms may lie in the mechanism of insulin-dependent diabetes mellitus development.

Hyperglycemia following Intralesional Corticosteroid Injection in a Patient with Type I Diabetes Mellitus

2014 ◽  
Vol 18 (4) ◽  
pp. 275-276 ◽  
Author(s):  
Patrick Fleming ◽  
Leah Drazek ◽  
James C. Shaw
Keyword(s):  
Diabetes Mellitus ◽  
Type I Diabetes ◽  
Corticosteroid Injection ◽  
Insulin Dependent Diabetes Mellitus ◽  
Local Effect ◽  
Dependent Diabetes Mellitus ◽  
Type I ◽  
Systemic Complications ◽  
Intralesional Corticosteroid ◽  
Insulin Dependent

Case Report: A 36-year-old woman with well-controlled type 1 diabetes mellitus reported hyperglycemia (plasma glucose peaked at 21.3 mmol/L) after her first injection with intralesional triamcinolone acetonide for alopecia areata. Conclusion: Intralesional corticosteroids are used to maximize local effect while presumably minimizing systemic complications. This adverse effect is an important consideration when treating patients with insulin-dependent diabetes mellitus, and it would be reasonable to counsel patients of such a possibility.

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