Two-Stage Genome-Wide Search in Inflammatory Bowel Disease: Strong Evidence for Susceptibility LOCI on Chromosomes 3, 7 and 12

1997 ◽  
Vol 93 (s37) ◽  
pp. 18P-19P
Author(s):  
Jack Satsangi ◽  
Miles Parkes ◽  
Eduoard Louis ◽  
KEN Welsh ◽  
John I Bell ◽  
...  
Keyword(s):  
Inflammatory Bowel Disease ◽  
Strong Evidence ◽  
Bowel Disease ◽  
Susceptibility Loci ◽  
Two Stage ◽  
Genome Wide ◽  
Genome Wide Search ◽  
Inflammatory Bowel

Two stage genome–wide search in inflammatory bowel disease provides evidence for susceptibility loci on chromosomes 3, 7 and 12

1996 ◽  
Vol 14 (2) ◽  
pp. 199-202 ◽  
Author(s):  
Jack Satsangi ◽  
Miles Parkes ◽  
Edouard Louis ◽  
Lara Hashimoto ◽  
Norihiro Kato ◽  
...  
Keyword(s):  
Inflammatory Bowel Disease ◽  
Bowel Disease ◽  
Susceptibility Loci ◽  
Two Stage ◽  
Genome Wide ◽  
Genome Wide Search ◽  
Inflammatory Bowel

scholarly journals Genome-wide search in Finnish families with inflammatory bowel disease provides evidence for novel susceptibility loci

2003 ◽  
Vol 11 (2) ◽  
pp. 112-120 ◽  
Author(s):  
Paulina Paavola-Sakki ◽  
Vesa Ollikainen ◽  
Tiina Heliö ◽  
Leena Halme ◽  
Ulla Turunen ◽  
...  
Keyword(s):  
Inflammatory Bowel Disease ◽  
Bowel Disease ◽  
Susceptibility Loci ◽  
Genome Wide ◽  
Genome Wide Search ◽  
Inflammatory Bowel

Stratification by CARD15 variant genotype in a genome-wide search for inflammatory bowel disease susceptibility loci

2003 ◽  
Vol 113 (6) ◽  
pp. 514-521 ◽  
Author(s):  
Sarah H. Shaw ◽  
Jochen Hampe ◽  
Ray White ◽  
Christopher G. Mathew ◽  
Mark E. Curran ◽  
...  
Keyword(s):  
Inflammatory Bowel Disease ◽  
Bowel Disease ◽  
Disease Susceptibility ◽  
Susceptibility Loci ◽  
Genome Wide ◽  
A Genome ◽  
Genome Wide Search ◽  
Variant Genotype ◽  
Inflammatory Bowel

566 LARGE META GENOME WIDE ASSOCIATION STUDY IDENTIFIED 30 NOVEL SUSCEPTIBILITY LOCI FOR INFLAMMATORY BOWEL DISEASE.

2020 ◽  
Vol 158 (6) ◽  
pp. S-117
Author(s):  
Takeo Naito ◽  
Gregory J. Botwin ◽  
Talin Haritunians ◽  
Michelle Khrom ◽  
Shishir Dube ◽  
...  
Keyword(s):  
Inflammatory Bowel Disease ◽  
Association Study ◽  
Bowel Disease ◽  
Genome Wide Association Study ◽  
Genome Wide Association ◽  
Susceptibility Loci ◽  
Genome Wide ◽  
Inflammatory Bowel

Genome-Wide Search Identified Genetic Variants that can Predict TNF Antagonist Responsiveness in Inflammatory Bowel Disease Patients

2017 ◽  
Vol 152 (5) ◽  
pp. S78-S79
Author(s):  
Ming-Hsi Wang ◽  
Parakkal Deepak ◽  
Jessica Friton ◽  
Laura H. Raffals ◽  
Jonathan A. Leighton ◽  
...  
Keyword(s):  
Inflammatory Bowel Disease ◽  
Bowel Disease ◽  
Genetic Variants ◽  
Genome Wide ◽  
Tnf Antagonist ◽  
Genome Wide Search ◽  
Inflammatory Bowel

A genome-wide scan in a canadian inflammatory bowel disease (IBD) population reveals two novel susceptibility loci

2000 ◽  
Vol 118 (4) ◽  
pp. A708
Author(s):  
John D. Rioux ◽  
Mark S. Silverberg ◽  
Mark J. Daly ◽  
A. Hillary Steinhart ◽  
Robin S. McLeod ◽  
...  
Keyword(s):  
Inflammatory Bowel Disease ◽  
Bowel Disease ◽  
Susceptibility Loci ◽  
Genome Wide ◽  
A Genome ◽  
Inflammatory Bowel ◽  
Genome Wide Scan

Identification of three novel susceptibility loci for inflammatory bowel disease in Koreans in an extended genome-wide association study

2021 ◽  
Author(s):  
Seulgi Jung ◽  
Byong Duk Ye ◽  
Ho-Su Lee ◽  
Jiwon Baek ◽  
Gyeonghoon Kim ◽  
...  
Keyword(s):  
Inflammatory Bowel Disease ◽  
Bowel Disease ◽  
Association Studies ◽  
Meta Analysis ◽  
Genome Wide Association ◽  
Genome Wide Association Studies ◽  
Susceptibility Loci ◽  
Data Set ◽  
Genome Wide ◽  
Inflammatory Bowel

Abstract Background and Aims Genome-wide association studies (GWAS) of inflammatory bowel disease (IBD) in multiple populations have identified over 240 susceptibility loci. We previously performed a largest-to-date Asian-specific IBD GWAS to identify 2 new IBD risk loci and confirm associations with 28 established loci. To identify additional susceptibility loci in Asians, we expanded our previous study design by doubling the case size with an additional data set of 1,726 cases and 378 controls. Methods An inverse-variance fixed-effects meta-analysis was performed between the previous and the new GWAS dataset, comprising a total of 3,195 cases and 4,419 controls, followed by replication in an additional 1,088 cases and 845 controls. Results The meta-analysis of Korean GWAS identified 1 novel locus for ulcerative colitis at rs76227733 on 10q24 (pcombined = 6.56 × 10 -9) and 2 novel loci for Crohn’s disease (CD) at rs2240751 on 19p13 (pcombined = 3.03 × 10 -8) and rs6936629 in on 6q22 (pcombined = 3.63 × 10 -8). Pathway-based analysis of GWAS data using MAGMA showed that MHC and antigenic stimulus-related pathways were more significant in Korean CD, whereas cytokine and transcription factor-related pathways were more significant in European CD. Phenotype variance explained by the polygenic risk scores derived from Korean data explained up to 14 % of variance of CD whereas those derived from European data explained 10%, emphasizing the need for large-scale genetic studies in this population. Conclusions The identification of novel loci not previously associated with IBD suggest the importance of studying the inflammatory bowel disease genetics in diverse populations.

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