Sex Differences in Correlates of Steady State and Pulsatile Component of Blood Pressure

1996 ◽  
Vol 91 (4) ◽  
pp. 385-389 ◽  
Author(s):  
A. Scuteri ◽  
A. M. Cacciafesta ◽  
M. G. Di Bernardo ◽  
A. M. De Propris ◽  
D. Recchi ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Body Mass Index ◽  
Regression Analysis ◽  
Mean Arterial Pressure ◽  
Arterial Pressure ◽  
Multiple Regression Analysis ◽  
Multiple Regression ◽  
Body Mass ◽  
Pulse Pressure ◽  
Coronary Insufficiency

1. The aim of the present study was to evaluate whether metabolic factors are linked to the steady component and the pulsatile component of blood pressure, evaluated as mean arterial pressure and pulse pressure respectively, in a sex-specific manner. 2. A cohort of 299 subjects (152 males, 147 females; 25–80 years of age) was studied. Patients presenting congestive heart failure, coronary insufficiency, severe valvular heart disease, neurological accident in the last 6 months, renal or respiratory failure, cancer, diabetes mellitus or acute infectious disease were excluded. None of the women was taking oral contraceptives or oestrogen supplementation. All cardioactive drugs were withdrawn at least 2 weeks before the subjects entered the study. 3. Men presented higher mean arterial pressure (120 ± 15 compared with 115 ± 16 mmHg, P < 0.01) and lower pulse pressure values (63 ± 16 compared with 67 ± 18 mmHg, P < 0.05) than women. In men, no significant relation between mean arterial pressure and the tested variables was detected; multiple regression analysis demonstrated that age contributed independently to the model for pulse pressure with a multiple r2 of 0.10 (P < 0.01). In women, body mass index contributed independently to the model for mean arterial pressure, with a multiple of 0.12 (P < 0.005); age and, to a lesser extent, body mass index, glycaemia and triglyceridaemia persisted as independent determinants of pulse pressure at the multiple regression analysis, with a multiple r2 of 0.20 (P < 0.001). 4. Our findings suggest that metabolic risk factors are associated differently with pulse pressure and mean arterial pressure values in the two sexes.

scholarly journals Raised body mass index and cardiovascular indices in secondary school students, South-South Nigeria

2018 ◽  
Vol 5 (5) ◽  
pp. 1719
Author(s):  
Bertilla U. Ezeonwu ◽  
Clifford O. Okike ◽  
Hyginus I. Opara ◽  
Leonard E. Abonyi ◽  
Obinna C. Ajaegbu ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Body Mass Index ◽  
Mean Arterial Pressure ◽  
Arterial Stiffness ◽  
Arterial Pressure ◽  
Body Mass ◽  
Pulse Pressure ◽  
School Students ◽  
Cross Sectional ◽  
Mean Values

Background: Raised body mass index (obesity and overweight), is abnormal or excessive accumulation of fat that may impair health.The prevalence of obesity in Nigerian adolescents ranges between 1 and 10%.In children, raised body mass index is complicated with the development of cardiovascular diseases,which are consequences of arterial stiffness. The hallmark of arterial stiffness is wide pulse pressure which precedes isolated elevation of systolic blood pressure. Other manifestations of arterial stiffness are elevated diastolic blood pressure and increased mean arterial pressure. This study educated the students on healthy lifestyle and checked their cardiovascular indices.Methods: This was a descriptive cross-sectional study of students. Their weight, height and blood pressure were measured and cardiovascular indices were calculated.Results: There were 248 students, age between 8 and 16 years, 135 (54.4%) were males with adolescents comprising 96.8%. The prevalence rate of wide pulse pressure, raised body mass index, elevated blood pressure and increased mean arterial pressure was 26.6%, 16.1%, 8.5% and 4.0% respectively. More females and early adolescents comparably had raised body mass index.Conclusions: The mean values for cardiovascular indices were comparably higher in those with raised body mass index.

Influence of Obesity on Plasma Fructosamine Concentration

1992 ◽  
Vol 38 (11) ◽  
pp. 2190-2192 ◽  
Author(s):  
J Woo ◽  
C Cockram ◽  
E Lau ◽  
A Chan ◽  
R Swaminathan
Keyword(s):  
Body Mass Index ◽  
Regression Analysis ◽  
Glycemic Control ◽  
Multiple Regression Analysis ◽  
Multiple Regression ◽  
Body Mass ◽  
Total Protein ◽  
Stepwise Multiple Regression ◽  
Stepwise Multiple Regression Analysis ◽  
Chinese Community

Abstract The influence of obesity on plasma fructosamine concentration was studied in 68 diabetic and 1335 nondiabetic subjects from a Chinese community. Obese nondiabetic men (body mass index &gt; 25 kg/m2) had lower fructosamine concentrations than nonobese nondiabetic men (body mass index &lt; or = 25 kg/m2); the pattern was similar for diabetic women. Stepwise multiple-regression analysis showed that, apart from known factors (total protein, albumin, and indices of glycemic control), fructosamine was also associated with body mass index and plasma fasting triglycerides. However, the contribution of these were small except in diabetic women. We conclude that the effect of obesity on fructosamine is small.

scholarly journals Factors Predicting Coronary Sinus Rupture following Cannula Insertion for Retrograde Cardioplegia

2011 ◽  
Vol 6 ◽  
pp. CMC.S7861 ◽  
Author(s):  
Feridoun Sabzi ◽  
Abdolhamid Zokaei
Keyword(s):  
Body Mass Index ◽  
Regression Analysis ◽  
Multiple Regression Analysis ◽  
Multiple Regression ◽  
Body Mass ◽  
Coronary Sinus ◽  
Artery Bypass ◽  
Bypass Graft ◽  
Retrograde Cardioplegia ◽  
Inexperienced Surgeon

Background Coronary sinus rupture (CSR) is a rare preventable complication of cannula insertion for retrograde cardioplegia. In the hands of an inexperienced surgeon, this complication has the risk of potential mortality and morbidity, and its repair is technically challenging. Techniques for repairing CSR have been reported previously. In this study, we determined predictors of CSR following coronary artery bypass graft (CABG) surgery. Methods Over a four-year period, we retrospectively analyzed 1500 patients in whom a retrograde coronary sinus catheter was used to administer cardioplegic solution. CSR occurred in 15 patients. (12 women and 3 men). Variables such as age, weight, body mass index, gender, aortic clamp time, pump time, cardiomegaly, ejection fraction, and number of grafts were determined for each patient. Factors correlated with CSR were analyzed using multiple regression analysis, and odd ratios of significant variables were determined. Results In multiple regression analysis, factors such as female gender, age, weight, and body mass index showed a significant correlation with CSR, and their odd ratios were 4.2, 1.0, 0.96, and 2.2, respectively. Conclusion In all 15 cases, a retrograde cannula with a self-inflatable balloon was used and 12 patients were woman with low body mass index. Forceful insertion due to coronary sinus web, fragility of arteries in thin patients, or a small coronary sinus caused CSR in the hands of an inexperienced surgeon.

scholarly journals Impact of body mass index on the psychopathological profile of obese women

2010 ◽  
Vol 32 (1) ◽  
pp. 42-46 ◽  
Author(s):  
Marcelo Papelbaum ◽  
Rodrigo Oliveira Moreira ◽  
Caroline Wust do Nascimento Gaya ◽  
Carolina Preissler ◽  
Walmir Ferreira Coutinho
Keyword(s):  
Body Mass Index ◽  
Regression Analysis ◽  
Multiple Regression Analysis ◽  
Multiple Regression ◽  
Beck Depression Inventory ◽  
Body Mass ◽  
Symptom Checklist ◽  
Obese Women ◽  
Medical Disorders ◽  
The Impact

OBJECTIVE: Obesity is a complex condition associated with a host of medical disorders. One common assumption is that obesity is also related to psychological and emotional complications. However, some studies have shown that obesity itself does not appear to be systematically associated with psychopathological outcomes.The objective of the present study was to evaluate the impact that the various degrees of obesity have on the psychopathological profile of obese patients. METHOD: The study sample consisted of 217 women classified as obese (body mass index > 30 kg/m²) who sought medical treatment for weight loss and were consecutively invited to participate in the study. Anthropometric data were registered for all participants. Psychiatric evaluations were performed using the Beck Depression Inventory and Symptom Checklist-90. Multiple regression analysis was used in order to determine whether any of the studied variables (age, level of education, Beck Depression Inventory score and body mass index) were independently correlated with the score on the different subscales of the Symptom Checklist-90. RESULTS: Only body mass index was found to correlate significantly with the score on the somatization subscale of the Symptom Checklist-90 (r = 0.148, p = 0.035). This correlation remained significant after multiple regression analysis (p = 0.03). No correlation was found between body mass index and the score on any of the other subscales. CONCLUSION: The degree of obesity did not correlate with any of the psychological profiles commonly described in the medical literature, including depression and anxiety. The correlation between obesity and somatization, although weak, might simply be related to an overlapping of symptoms.

Norepinephrine Dosing in Obese and Nonobese Patients With Septic Shock

2016 ◽  
Vol 25 (1) ◽  
pp. 27-32 ◽  
Author(s):  
John J. Radosevich ◽  
Asad E. Patanwala ◽  
Brian L. Erstad
Keyword(s):  
Body Mass Index ◽  
Septic Shock ◽  
Mean Arterial Pressure ◽  
Arterial Pressure ◽  
Body Mass ◽  
Secondary Outcome ◽  
Obese Patients ◽  
Hemodynamic Status ◽  
Norepinephrine Infusion ◽  
Nonobese Patients

Background Whether or not norepinephrine infusions for support of hemodynamic status in patients with septic shock should be weight based is unknown. This situation is particularly pertinent in patients who are extremely overweight or obese. Objective To compare dosing requirements and effect of norepinephrine on blood pressure in obese and nonobese patients with septic shock. Methods In a retrospective cohort study, data on adult patients with septic shock who received norepinephrine infusion for support of hemodynamic status in a tertiary care, academic medical center were analyzed. Patients were categorized as obese (body mass index ≥ 30) or nonobese (body mass index &lt; 30). The primary outcome was dosing requirements of norepinephrine at 60 minutes after the start of the infusion. The secondary outcome was the log-transformed ratio of mean arterial pressure to norepinephrine. Results The final cohort consisted of 100 obese and 100 nonobese patients. Mean norepinephrine infusion rate at 60 minutes was 0.09 (SD, 0.08) μg/kg per minute in the obese group and 0.13 (SD, 0.14) μg/kg per minute in the nonobese group (P = .006). The non–weight-based dose at 60 minutes was 9 μg/min in obese patients and 8 μg/min in nonobese patients (P = .72). The log transformed mean arterial pressure to norepinephrine ratio at 60 minutes was 2.5 (SD, 0.9) in obese patients and 2.5 (SD, 0.8) in nonobese patients (P = .54) Conclusions Compared with nonobese patients, obese patients with septic shock require lower weight-based doses of norepinephrine and similar total norepinephrine doses.

Aerobic Capacity, Obesity, and Atherosclerotic Risk Factors in Male Adolescents

PEDIATRICS ◽  
1985 ◽  
Vol 75 (5) ◽  
pp. 813-818
Author(s):  
Raymond R. Fripp ◽  
James L. Hodgson ◽  
Peter O. Kwiterovich ◽  
John C. Werner ◽  
H. Gregg Schuler ◽  
...  
Keyword(s):  
Risk Factors ◽  
Blood Pressure ◽  
Body Mass Index ◽  
Regression Analysis ◽  
Body Mass ◽  
Linear Regression Analysis ◽  
Density Lipoprotein ◽  
Plasma Triglyceride ◽  
Lipoprotein Cholesterol ◽  
Atherosclerotic Risk Factors

Correlations between aerobic capacity, obesity, and atherosclerotic risk factors were evaluated in adolescents with low-to-moderate levels of physical fitness. Subjects with higher levels of fitness had a more favorable risk profile with decreased body mass index, lower systolic and diastolic blood pressure and plasma triglyceride levels, and higher plasma high-density lipoprotein-cholesterol levels. Simple linear regression analysis revealed an association between body mass index and blood pressure, plasma triglyceride and plasma highdensity lipoprotein-cholesterol. The level of aerobic fitness as determined by exercise duration was also associated with the same atherosclerotic risk factors. However, multiple linear regression analysis demonstrated that body mass index provided the largest explanation, by those variables examined, of the interindividual variance in blood pressure, plasma triglyceride, and high-density lipoprotein-cholesterol. Aerobic fitness contributed only minimally to the variation in these risk factors. These findings suggest that if aerobic conditioning is used to modify atherosclerotic risk factors, it should be accompanied by a reduction in weight in adolescents with low-to-moderate levels of physical fitness.

The influence of different surgical procedures on hypertension after repair of coarctation

2005 ◽  
Vol 15 (5) ◽  
pp. 477-480 ◽  
Author(s):  
Ugo Giordano ◽  
Salvatore Giannico ◽  
Attilio Turchetta ◽  
Fatma Hammad ◽  
Flaminia Calzolari ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Cardiac Output ◽  
Mean Arterial Pressure ◽  
Arterial Pressure ◽  
Systolic Blood Pressure ◽  
Diastolic Blood Pressure ◽  
Pulse Pressure ◽  
Ambulatory Monitoring ◽  
Peak Exercise ◽  
End To End

We measured resting and exercise haemodynamics, as well as 24-hour ambulatory blood pressure, so as to study the influence on development of hypertension in children after repair of coarctation by either construction of a subclavian flap or end-to-end anastamosis. The patients in both groups were studied a mean time of 13 years after surgery. Thus, we divided 43 children who had undergone surgical repair of coarctation, and who were not on antihypertensive therapy, into a group of 22 patients who had undergone subclavian flap repair, with a mean age of 14 plus or minus 2.6 years, and another group of 21 patients undergoing end-to-end anastomosis, with a mean age of 13.5 plus or minus 3.9 years. We examined blood pressure at rest and during exercise, along with the measurement of cardiac output using impedance cardiography, and during 24-hour ambulatory monitoring. We recorded systolic and diastolic blood pressures, pulse pressure, cardiac output and total peripheral vascular resistance at rest and at peak exercise. During ambulatory monitoring, we measured mean pressures over 24 hours, in daytime and nighttime, 24-hour pulse pressure, and 24-hour mean arterial pressure. Student's t test was used to judge significance, accepting this when p was less than 0.05. The group repaired using the subclavian flap showed significantly disadvantageous differences for diastolic blood pressure at rest, systolic blood pressure at peak exercise and for 24-hour systolic and diastolic blood pressure, 24-hour mean arterial pressure, and daytime and nighttime systolic blood pressure during ambulatory monitoring. Our findings suggest that, after repair using the subclavian flap in comparison to end-to-end anastomosis, patients show a higher incidence of late hypertension, both during exercise and ambulatory monitoring. The data indicate different residual aortic stiffnesses, these being lower after end-to-end anastomosis, which may be due to the greater resection of the abnormal aortic tissue when coarctation is repaired using the latter technique.

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