Voltage- and Ca2+-Dependent K+ Channels in K+ Secreting Rat Distal Colon

1996 ◽  
Vol 90 (s34) ◽  
pp. 6P-6P
Author(s):  
I Butterfield ◽  
GI Sandle
Keyword(s):  
Distal Colon ◽  
K Channels ◽  
Rat Distal Colon

scholarly journals VIP- and PACAP-mediated nonadrenergic, noncholinergic inhibition in longitudinal muscle of rat distal colon: involvement of activation of charybdotoxin- and apamin-sensitive K+ channels

1996 ◽  
Vol 119 (4) ◽  
pp. 623-630 ◽  
Author(s):  
Masami Kishi ◽  
Tadayoshi Takeuchi ◽  
Naowarat Suthamnatpong ◽  
Toshiaki Ishii ◽  
Hideaki Nishio ◽  
...  
Keyword(s):  
Longitudinal Muscle ◽  
Distal Colon ◽  
K Channels ◽  
Rat Distal Colon

scholarly journals The flavonol quercetin activates basolateral K+ channels in rat distal colon epithelium

2002 ◽  
Vol 135 (5) ◽  
pp. 1183-1190 ◽  
Author(s):  
Rainer Cermak ◽  
Gisela Kuhn ◽  
Siegfried Wolffram
Keyword(s):  
Distal Colon ◽  
K Channels ◽  
Rat Distal Colon ◽  
Distal Colon Epithelium

W1645 Intermediate (KCNN4) and Large (maxi-K) Conductance K+ Channels Contribute to Enhanced K+ Secretion in Rat Distal Colon During Dietary K+- Loading

2009 ◽  
Vol 136 (5) ◽  
pp. A-709
Author(s):  
Nanda Kumar Navalpur Shanmugam ◽  
Geoffrey I. Sandle ◽  
Vazhaikkurichi M. Rajendran
Keyword(s):  
Distal Colon ◽  
K Channels ◽  
Rat Distal Colon ◽  
K Secretion

Adenosine A3 receptor expression in peplidergic neural circuits of the rat distal colon

2001 ◽  
Vol 120 (5) ◽  
pp. A177-A177
Author(s):  
S SHARP ◽  
J YU ◽  
J GUZMAN ◽  
J XUE ◽  
H COOKE ◽  
...  
Keyword(s):  
Neural Circuits ◽  
Distal Colon ◽  
Receptor Expression ◽  
Adenosine A3 Receptor ◽  
Rat Distal Colon

Fibre-free diet leads to impairment of neuronally mediated muscle contractile response in rat distal colon

2006 ◽  
Vol 18 (12) ◽  
pp. 1093-1101 ◽  
Author(s):  
r. mitsui ◽  
s.-i. karaki ◽  
y. kubo ◽  
y. sugiura ◽  
a. kuwahara
Keyword(s):  
Contractile Response ◽  
Distal Colon ◽  
Rat Distal Colon ◽  
Muscle Contractile

Dietary fish oils decrease bradykinin-induced secretion in rat distal colon

1997 ◽  
Vol 17 (4) ◽  
pp. 693-702 ◽  
Author(s):  
Kumiko Yamazaki ◽  
Takaji Yajima ◽  
Tamotsu Kuwata
Keyword(s):  
Distal Colon ◽  
Fish Oils ◽  
Rat Distal Colon ◽  
Dietary Fish

Melatonin inhibits prostaglandin E2- and sodium nitroprusside-induced ion secretion in rat distal colon

2008 ◽  
Vol 581 (1-2) ◽  
pp. 164-170 ◽  
Author(s):  
Libor Mrnka ◽  
Miroslav Hock ◽  
Markéta Rybová ◽  
Jiří Pácha
Keyword(s):  
Prostaglandin E2 ◽  
Sodium Nitroprusside ◽  
Distal Colon ◽  
Ion Secretion ◽  
Rat Distal Colon

Bicarbonate secretion in rat distal colon in vitro: a measurement technique

1988 ◽  
Vol 254 (3) ◽  
pp. C383-C390 ◽  
Author(s):  
G. M. Feldman ◽  
S. F. Berman ◽  
R. L. Stephenson
Keyword(s):  
Short Circuit ◽  
Distal Colon ◽  
Apparent Permeability ◽  
Chemical Gradients ◽  
Acid Generation ◽  
Rat Distal Colon ◽  
Tissue Surfaces ◽  
Apparent Permeability Coefficient ◽  
Transepithelial Voltage

To study HCO3- secretion in rat distal colon, we utilized a technique that permits control of electrical and chemical transepithelial gradients. With symmetrical solutions (pH 7.4, [HCO3-] 25 mM, and CO2 tension 40 mmHg) bathing both tissue surfaces and under short-circuit conditions, HCO3- secretion remained stable for greater than 4 h at 1 mueq. h-1.cm-2. As the mucosal solution was alkalinized, the serosal solution was acidified at 3.1 mueq.h-1.cm-2. Ninety-four percent of serosal acidification was accounted for by the rate of metabolic lactic acid generation and transepithelial HCO3- secretion. Clamping transepithelial voltage reversibly affected net HCO3- secretion, and a linear relationship existed between clamped mucosal voltage and net HCO3- flux (r = 0.99); mucosal voltage of -68 mV completely inhibited net secretion. The apparent permeability coefficient of the colon to HCO3- is 2.8 X 10(-6) cm/s. One millimolar ouabain completely inhibited net HCO3- secretion. Acetazolamide (10(-4) M) inhibited secretion by approximately 50%, whereas a 10(-3) M concentration inhibited secretion by 90%. These data demonstrate that net colonic HCO3- secretion can be measured without imposed electrical and chemical gradients and that this flux is voltage sensitive and depends on carbonic anhydrase and Na+-K+-ATPase activities.

Sign in / Sign up

Export Citation Format

Share Document