Rapid Production of Elisa Antigens from Roller Cultures of Parainfluenza Virus Type 1 and Influenza Virus Type a Isolates

1995 ◽  
Vol 89 (s33) ◽  
pp. 47P-47P
Author(s):  
SJ Cai ◽  
WH Taylor
Keyword(s):  
Influenza Virus ◽  
Virus Type ◽  
Type A ◽  
Parainfluenza Virus ◽  
Rapid Production ◽  
Roller Cultures

Safety and immunogenicity of intranasal murine parainfluenza virus type 1 (Sendai virus) in healthy human adults

Vaccine ◽  
2004 ◽  
Vol 22 (23-24) ◽  
pp. 3182-3186 ◽  
Author(s):  
Karen S Slobod ◽  
Jerry L Shenep ◽  
Jorge Luján-Zilbermann ◽  
Kim Allison ◽  
Brita Brown ◽  
...  
Keyword(s):  
Virus Type ◽  
Sendai Virus ◽  
Parainfluenza Virus ◽  
Healthy Human ◽  
Human Adults

scholarly journals Human parainfluenza virus type 1 regulates cholesterol biosynthesis and establishes quiescent infection in human airway cells

2021 ◽  
Vol 17 (9) ◽  
pp. e1009908
Author(s):  
Yuki Kurebayashi ◽  
Shringkhala Bajimaya ◽  
Masahiro Watanabe ◽  
Nicholas Lim ◽  
Michael Lutz ◽  
...  
Keyword(s):  
Virus Type ◽  
Cholesterol Biosynthesis ◽  
Parainfluenza Virus ◽  
Type I ◽  
Human Airway ◽  
Virion Release ◽  
Infected Cells ◽  
Human Parainfluenza Virus ◽  
Airway Cells

Human parainfluenza virus type 1 (hPIV1) and 3 (hPIV3) cause seasonal epidemics, but little is known about their interaction with human airway cells. In this study, we determined cytopathology, replication, and progeny virion release from human airway cells during long-term infection in vitro. Both viruses readily established persistent infection without causing significant cytopathic effects. However, assembly and release of hPIV1 rapidly declined in sharp contrast to hPIV3 due to impaired viral ribonucleocapsid (vRNP) trafficking and virus assembly. Transcriptomic analysis revealed that both viruses induced similar levels of type I and III IFNs. However, hPIV1 induced specific ISGs stronger than hPIV3, such as MX2, which bound to hPIV1 vRNPs in infected cells. In addition, hPIV1 but not hPIV3 suppressed genes involved in lipid biogenesis and hPIV1 infection resulted in ubiquitination and degradation of 3-hydroxy-3-methylglutaryl-coenzyme A reductase, a rate limiting enzyme in cholesterol biosynthesis. Consequently, formation of cholesterol-rich lipid rafts was impaired in hPIV1 infected cells. These results indicate that hPIV1 is capable of regulating cholesterol biogenesis, which likely together with ISGs contributes to establishment of a quiescent infection.

scholarly journals Evidence that mild or asymptomatic human H5N1 infections have not occurred in a Cambodian village with poultry infections

2006 ◽  
Vol 11 (36) ◽  
Author(s):  
Collective Influenza team (ECDC)
Keyword(s):  
Influenza Virus ◽  
Risk Factor ◽  
Virus Type ◽  
Household Survey ◽  
Type A ◽  
Population Based ◽  
H5n1 Infection ◽  
Human H5n1

A retrospective serologic and risk factor population-based household survey for influenza virus type A/H5N1 infection was carried out in a Cambodian village where there had been extensive poultry deaths attributed to A/H5N1

scholarly journals A study of genetic variability of human parainfluenza virus type 1 in Croatia, 2011–2014

2016 ◽  
Vol 65 (8) ◽  
pp. 793-803 ◽  
Author(s):  
Tanja Košutić-Gulija ◽  
Anamarija Slovic ◽  
Sunčanica Ljubin-Sternak ◽  
Gordana Mlinarić-Galinović ◽  
Dubravko Forčić
Keyword(s):  
Genetic Variability ◽  
Virus Type ◽  
Parainfluenza Virus ◽  
Human Parainfluenza Virus

scholarly journals Start of the influenza season 2008-9 in Europe - increasing influenza activity moving from West to East dominated by A(H3N2)

2009 ◽  
Vol 14 (3) ◽  
Author(s):  
N Goddard ◽  
P Zucs ◽  
B Ciancio ◽  
F Plata ◽  
O Hungnes ◽  
...  
Keyword(s):  
Influenza Virus ◽  
Influenza Vaccine ◽  
Northern Hemisphere ◽  
Virus Type ◽  
Influenza Season ◽  
Type A ◽  
Neuraminidase Inhibitors ◽  
Influenza Activity

The influenza season 2008-9 started in week 49 of 2008 and is so far characterised by influenza virus type A subtype H3N2. Isolates of this subtype that were tested proved susceptible to neuraminidase inhibitors, but resistant to M2 inhibitors. The circulating A(H3N2) viruses are antigenically similar to the component in the current northern hemisphere influenza vaccine.

scholarly journals A novel human parainfluenza virus type 1 (HPIV1) with separated P and C genes is useful for generating C gene mutants for evaluation as live-attenuated virus vaccine candidates

Vaccine ◽  
2010 ◽  
Vol 28 (3) ◽  
pp. 767-779 ◽  
Author(s):  
Emmalene J. Bartlett ◽  
Ann-Marie Cruz ◽  
Jim Boonyaratanakornkit ◽  
Janice Esker ◽  
Adam Castaño ◽  
...  
Keyword(s):  
Virus Type ◽  
Virus Vaccine ◽  
Parainfluenza Virus ◽  
Vaccine Candidates ◽  
Attenuated Virus ◽  
Human Parainfluenza Virus

scholarly journals Attenuation and efficacy of human parainfluenza virus type 1 (HPIV1) vaccine candidates containing stabilized mutations in the P/C and L genes

2007 ◽  
Vol 4 (1) ◽  
pp. 67 ◽  
Author(s):  
Emmalene J Bartlett ◽  
Adam Castaño ◽  
Sonja R Surman ◽  
Peter L Collins ◽  
Mario H Skiadopoulos ◽  
...  
Keyword(s):  
Virus Type ◽  
Parainfluenza Virus ◽  
Vaccine Candidates ◽  
Human Parainfluenza Virus
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