Diagnosis of Kallmann's Syndrome at Eighteen Months of Age by Demonstration of Base Substitution in Kal Gene by Direct PCR-Sequencing

1995 ◽  
Vol 89 (s33) ◽  
pp. 6P-7P
Author(s):  
V M Duke ◽  
P A De Zoysa ◽  
R Quinton ◽  
C S Smith ◽  
P-M G Bouloux
Keyword(s):  
Base Substitution ◽  
Direct Pcr ◽  
Kallmann's Syndrome ◽  
Kallmann’S Syndrome

A Case of Kallmann's Syndrome with Unilateral Renal Aplasia and Diabetes Mellitus

2005 ◽  
Vol 20 (1) ◽  
pp. 96 ◽  
Author(s):  
En Jung Lee ◽  
Sung Wook Hong ◽  
Yun Ki Hong ◽  
Ji Sung Yoon ◽  
Ji O Mok ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Kallmann's Syndrome ◽  
Renal Aplasia ◽  
Kallmann’S Syndrome

scholarly journals A Case of Kallmann's Syndrome Mildly Presenting as Secondary Amenorrhea

2007 ◽  
Vol 22 (2) ◽  
pp. 130
Author(s):  
Na Rae Joo ◽  
Cheol Young Park ◽  
Hong Ju Moon ◽  
Jun Goo Kang ◽  
Sung Hee Ihm ◽  
...  
Keyword(s):  
Secondary Amenorrhea ◽  
Kallmann's Syndrome ◽  
Kallmann’S Syndrome

Craniofacial Morphology in Patients with Kallmann's Syndrome with and without Cleft Lip and Palate

1997 ◽  
Vol 34 (5) ◽  
pp. 417-424 ◽  
Author(s):  
Kirsten Mølsted ◽  
Inger Kjær ◽  
Aleksander Giwercman ◽  
Søren Vesterhauge ◽  
Niels Erik Skakkebæk
Keyword(s):  
Luteinizing Hormone ◽  
Cleft Lip ◽  
Cleft Lip And Palate ◽  
Hypogonadotropic Hypogonadism ◽  
Craniofacial Morphology ◽  
Endocrine Treatment ◽  
Anterior Cranial Base ◽  
Kallmann's Syndrome ◽  
Maxilla And Mandible ◽  
Kallmann’S Syndrome

Objective: Kallmann's syndrome is characterized by the association of hypogonadotropic hypogonadism and anosmia or hyposmia. The principal endocrine defect of hypogonadotropic hypogonadism is a failure to secrete luteinizing hormone-releasing hormone (LHRH), resulting in underdevelopment of the pituitary gonadotropes and an inability to synthesize and release luteinizing hormone and follicle-stimulating hormone. The purpose of the present investigation was to describe the dentition and the craniofacial morphology in patients diagnosed with Kallmann's syndrome. Design: The sample consisted of 11 patients, 2 of whom also had bilateral cleft lip and palate. Radiographic investigations, including cephalometry, were performed. Comparisons were made to normal individuals and to cleft lip individuals without Kallmann's syndrome. Results: Dentition: tooth agenesis occurred more frequently in patients with Kallmann's syndrome. Craniofacial morphology: Increased mandibular inclination and mandibular angulation were seen in Kallmann patients. When clefting also occurred, extreme retrognathism of both maxilla and mandible was seen, a deviation which seemingly worsened during growth. The anterior cranial base and the sphenoid bone showed an altered morphology in one of the patients with Kallman's syndrome. Conclusions: An early diagnosis of Kallmann's syndrome is very important because the prognosis for endocrine treatment thereby improves, and therefore, it is recommended that the sense of smell be evaluated in patients with the craniofacial morphology described.

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