Moderate Exercise Enhances the Effect of Interferon Gamma on Murine Resident Peritoneal Macrophage

1994 ◽  
Vol 87 (s1) ◽  
pp. 25-26
Author(s):  
A Tamagawa ◽  
R Nagatomi ◽  
M Ohsako ◽  
H Ohmori ◽  
Y Yamauchi
Keyword(s):  
Interferon Gamma ◽  
Peritoneal Macrophage ◽  
Moderate Exercise ◽  
Resident Peritoneal Macrophage

scholarly journals Gata6 regulates aspartoacylase expression in resident peritoneal macrophages and controls their survival

2014 ◽  
Vol 211 (8) ◽  
pp. 1525-1531 ◽  
Author(s):  
Emmanuel L. Gautier ◽  
Stoyan Ivanov ◽  
Jesse W. Williams ◽  
Stanley Ching-Cheng Huang ◽  
Genevieve Marcelin ◽  
...  
Keyword(s):  
Peritoneal Macrophage ◽  
Endocrine Cells ◽  
Marked Decrease ◽  
Peritoneal Macrophages ◽  
Alternative Activation ◽  
Activation Markers ◽  
Normal Number ◽  
Proliferation And Differentiation ◽  
Resident Peritoneal Macrophage ◽  
Metabolic Regulators

The transcription factor Gata6 regulates proliferation and differentiation of epithelial and endocrine cells and cancers. Among hematopoietic cells, Gata6 is expressed selectively in resident peritoneal macrophages. We thus examined whether the loss of Gata6 in the macrophage compartment affected peritoneal macrophages, using Lyz2-Cre x Gata6flox/flox mice to tackle this issue. In Lyz2-Cre x Gata6flox/flox mice, the resident peritoneal macrophage compartment, but not macrophages in other organs, was contracted, with only a third the normal number of macrophages remaining. Heightened rates of death explained the marked decrease in peritoneal macrophage observed. The metabolism of the remaining macrophages was skewed to favor oxidative phosphorylation and alternative activation markers were spontaneously and selectively induced in Gata6-deficient macrophages. Gene expression profiling revealed perturbed metabolic regulators, including aspartoacylase (Aspa), which facilitates generation of acetyl CoA. Mutant mice lacking functional Aspa phenocopied the higher propensity to death and led to a contraction of resident peritoneal macrophages. Thus, Gata6 regulates differentiation, metabolism, and survival of resident peritoneal macrophages.

Interleukin-4, interferon-gamma and interleukin-5 in peripheral blood of children with moderate atopic asthma

1997 ◽  
Vol 27 (11) ◽  
pp. 1254-1260 ◽  
Author(s):  
M. O. HOEKSTRA ◽  
Y. HOEKSTRA ◽  
D. DE REUS ◽  
B. RUTGERS ◽  
J. GERRITSEN ◽  
...  
Keyword(s):  
Interferon Gamma ◽  
Peripheral Blood ◽  
Atopic Asthma ◽  
Interleukin 4 ◽  
Interleukin 5
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