Urinary Endothelin-1-Like Immunoreactivity in Young Male Patients with Testicular Cancer Treated by CIS-Platinum: Comparison with other Urinary Parameters

1994 ◽  
Vol 86 (6) ◽  
pp. 703-707 ◽  
Author(s):  
Masayuki Takeda ◽  
Takeshi Komeyama ◽  
Toshiki Tsutsui ◽  
Takaki Mizusawa ◽  
GO Hideto ◽  
...  
Keyword(s):  
Testicular Cancer ◽  
Urinary Excretion ◽  
Young Male ◽  
Tubular Injury ◽  
Endothelin 1 ◽  
Β2 Microglobulin ◽  
Male Patients ◽  
Urinary Parameters ◽  
Renal Tubular

1. Urinary excretion of endothelin-1-like immunoreactivity and urinary excretion of other parameters (β2-microglobulin, N-acetyl-β-d-glucosaminidase and microalbumin) were measured before, within 1 week after and 2 weeks after the administration of cis-platinum in five young male patients with testicular cancer (mean age 33.0 years) and were compared. 2. Urinary endothelin-1-like immunoreactivity/creatinine during, 1 week after, and 2 weeks after cis-platinum treatment was significantly higher than before cis-platinum. There was no difference in urinary endothelin-1-like immunoreactivity/creatinine during, 1 week after and 2 weeks after cis-platinum. 3. Among the four parameters, urinary endothelin-1-like immunoreactivity/creatinine showed the highest level after cis-platinum treatment. Urinary β2-microglobulin/creatinine most rapidly returned to normal levels after cis-platinum. 4. Although urinary endothelin-1-like immunoreactivity/creatinine did not show any significant correlations with urinary N-acetyl-β-d-glucosaminidase (r = 0.291, not significant) or urinary microalbumin/creatinine (r = 0.076, not significant), it showed a significant correlation with urinary β2-microglobulin/creatinine (r = 0.475, P < 0.05). 5. These results suggest that endothelin-1 may be a sensitive urinary parameter in detecting cis-platinum-induced renal tubular injury.

Changes in Urinary Excretion of Endothelin-1-like Immunoreactivity in Patients With Testicular Cancer Receiving High-Dose Cisplatin Therapy

1994 ◽  
Vol 24 (1) ◽  
pp. 12-16 ◽  
Author(s):  
Masayuki Takeda ◽  
Takeshi Komeyama ◽  
Toshiki Tsutsui ◽  
Takaki Mizusawa ◽  
Hideto Go ◽  
...  
Keyword(s):  
Testicular Cancer ◽  
Urinary Excretion ◽  
High Dose ◽  
Endothelin 1 ◽  
Cisplatin Therapy

scholarly journals Urinary β2-Microglobulin is a Sensitive Indicator for Renal Tubular Injury

2014 ◽  
Vol 1 (1) ◽  
Author(s):  
Zeng X ◽  
Hossain D ◽  
Bostwick DG ◽  
Herrera GA ◽  
Ballester B ◽  
...  
Keyword(s):  
Sensitive Indicator ◽  
Tubular Injury ◽  
Β2 Microglobulin ◽  
Renal Tubular

Assessment of urinary retinol-binding protein as an index of proximal tubular injury.

1987 ◽  
Vol 33 (6) ◽  
pp. 775-779 ◽  
Author(s):  
A M Bernard ◽  
A A Vyskocil ◽  
P Mahieu ◽  
R R Lauwerys
Keyword(s):  
Urinary Excretion ◽  
Binding Protein ◽  
Retinol Binding Protein ◽  
Tubular Damage ◽  
Tubular Injury ◽  
Renal Tubular Damage ◽  
Acid Urine ◽  
Beta 2 ◽  
Renal Tubular ◽  
Beta 2 Microglobulin

Abstract The urinary excretion of retinol-binding protein (RBP), beta 2-microglobulin (beta 2-m), and beta-N-acetyl-D-glucosaminidase was monitored in patients with renal tubular damage secondary to multiple injuries, rhabdomyolysis, antibiotic treatment, or poisoning by various chemicals such as solvents, heavy metals, or pesticides. In almost all cases, RBP proved to be a more sensitive index of renal tubular damage than was beta-N-acetyl-D-glucosaminidase and, being more stable in acid urine, a more practical analyte to measure than was beta 2-m. We corroborated this finding by studying the relationships between these three analytes in more than 150 patients. On the average, an increase in the urinary excretion of beta-N-acetyl-D-glucosaminidase becomes detectable when urinary RBP already exceeds the normal value by 50- to 100-fold. In urines with pH greater than 6, RBP and beta 2-m concentrations are well correlated (r = 0.93, n = 150), beta 2-m tending to be more frequently positive (i.e., greater than 311 micrograms/L). But in urines with pH less than 6 (about 30-40% of the samples), the RBP/beta 2-m concentration ratio increases as pH decreases, up to 500 in some patients with massive tubular injury. Because the renal uptake of proteins involves a saturable process, the urinary excretion of RBP, like that of beta 2-m, specifically reflects the reabsorption capacity of proximal tubules only when the glomerular filtration rate is normal or slightly impaired (i.e., serum creatinine less than 20 mg/L). Under these conditions the determination of RBP protein in urine appears the most appropriate test when early detection of tubular injury is desirable.

THE INFLUENCE OF 17α-METHYL-19-NORTESTOSTERONE ON THE ENDOCRINE FUNCTION OF THE ADRENAL CORTEX

1960 ◽  
Vol XXXIII (III) ◽  
pp. 388-400 ◽  
Author(s):  
L. G. Huis in 't Veld ◽  
B. Louwerens ◽  
P. A. F. van der Spek
Keyword(s):  
Urinary Excretion ◽  
Adrenal Cortex ◽  
Direct Effect ◽  
Chorionic Gonadotrophin ◽  
Endocrine Function ◽  
List Type ◽  
Prolonged Administration ◽  
Acth Secretion ◽  
Male Patients ◽  
Normal Males

ABSTRACT In two male patients and two castrated males, the influence of corticotrophin (ACTH) on the urinary excretion of neutral 17-ketosteroids and 17-hydroxycorticosteroids was determined before and during a period in which patients were treated with 5 mg 17α-methyl-19-nortestosterone (MNT) daily. In two castrated males, moreover, the influence of chorionic gonadotrophin and ACTH + chorionic gonadotrophin on the urinary excretion of 17-ketosteroids and 17-hydroxycorticosteroids was determined before and during a period of treatment with 5 mg MNT daily. Prolonged administration of MNT causes a decrease in the urinary excretion of neutral 17-ketosteroids and 17-hydroxycorticosteroids both in the normal males and in the male castrates. ACTH caused an increase in the urinary excretion of 17-ketosteroids and 17-hydroxycorticosteroids before and during MNT administration. During MNT administration this increase (expressed in mg/24 hours) was ≤ the increase produced by the same dose of ACTH prior to MNT administration. In two male castrates treated with MNT, chorionic gonadotrophin caused no increase in the urinary excretion of 17-ketosteroids and 17-hydroxycorticosteroids. The effect obtained before and during MNT administration by administration of ACTH + chorionic gonadotrophin did not exceed the effect obtained by the same dose of ACTH alone. Our conclusion is that the effect of MNT on the excretion of adrenocortical steroids is not due to the inhibition of the ACTH secretion. The possibility of a direct effect of MNT on the adrenal cortex has not been excluded with complete certainty. A change in the corticosteroid metabolism due to the influence of MNT, however, must also be taken into consideration.

470-P: SIK2 Protects against Renal Tubular Injury by Inhibiting Endoplasmic Reticulum Stress

Diabetes ◽  
2020 ◽  
Vol 69 (Supplement 1) ◽  
pp. 470-P
Author(s):  
XIAOYU LIAO ◽  
BINGYAO LIU ◽  
HONGTING ZHENG
Keyword(s):  
Endoplasmic Reticulum ◽  
Endoplasmic Reticulum Stress ◽  
Tubular Injury ◽  
Renal Tubular

scholarly journals Effect of suramin on urinary excretion of diabetes-induced glomerular and tubular injury parameters in rats

2021 ◽  
Vol 139 ◽  
pp. 111683
Author(s):  
K. Sałaga-Zaleska ◽  
P. Pikul ◽  
E. Kreft ◽  
S. Herman ◽  
G. Chyła ◽  
...  
Keyword(s):  
Urinary Excretion ◽  
Tubular Injury

68 – Neurophysiological profile (EEG, auditory ERP) in the first episode young male patients

2008 ◽  
Vol 98 ◽  
pp. 61-62
Author(s):  
I. Lebedeva ◽  
V. Kaleda ◽  
A. Barkhatova ◽  
M. Omelchenko ◽  
S. Golubev
Keyword(s):  
Young Male ◽  
First Episode ◽  
Male Patients ◽  
Auditory Erp
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