The Synthesis of Cardiac Contractile Proteins in Hypertension and Its Modulation by Acute Ethanol Toxicity

1994 ◽  
Vol 86 (s30) ◽  
pp. 28P-28P
Author(s):  
T Siddiq ◽  
P J Richardson ◽  
V R Preedy
Keyword(s):  
Contractile Proteins ◽  
Cardiac Contractile ◽  
Ethanol Toxicity ◽  
Acute Ethanol ◽  
Cardiac Contractile Proteins

scholarly journals Relative synthesis of cardiac contractile proteins. Evidence for synthesis from the same precursor pool

1981 ◽  
Vol 194 (3) ◽  
pp. 673-678 ◽  
Author(s):  
C D Evans ◽  
S S Schreiber ◽  
M Oratz ◽  
M A Rothschild
Keyword(s):  
Light Chain ◽  
Contractile Proteins ◽  
Light Chains ◽  
Myosin Heavy Chains ◽  
Perfused Heart ◽  
Precursor Pool ◽  
Heavy Chains ◽  
Cardiac Contractile ◽  
Specific Activities ◽  
Cardiac Contractile Proteins

The relative molar synthesis of cardiac contractile proteins has been measured in the perfused heart under control haemodynamic conditions. This synthesis, of myosin heavy chains, individual light chains (1 and 2), actin and tropomyosin, was determined from isolated guinea-pig hearts perfused for 3h simultaneously with constant specific radioactivities and concentrations of [3H]lysine and [3H]phenylalanine.The data strongly suggest that all of the proteins studied were synthesized from the same precursor pools of lysine and phenylalanine, since the ratio of the specific activities of the two labels was the same in all of the proteins. Measurement of molar synthesis of each contractile protein was the same with either labelled amino acid. Under control haemodynamic-perfusion conditions, the relative molar synthesis of the contractile proteins was actin greater than heavy chains greater than light chain 2 greater than light chain 1 greater than tropomyosin.

scholarly journals Endothelial cells are required for the cAMP regulation of cardiac contractile proteins.

1993 ◽  
Vol 90 (7) ◽  
pp. 2885-2889 ◽  
Author(s):  
G. McClellan ◽  
A. Weisberg ◽  
L. E. Lin ◽  
D. Rose ◽  
C. Ramaciotti ◽  
...  
Keyword(s):  
Endothelial Cells ◽  
Contractile Proteins ◽  
Cardiac Contractile ◽  
Cardiac Contractile Proteins

scholarly journals Alterations in cardiac contractile proteins due to oxygen free radicals

1991 ◽  
Vol 1074 (1) ◽  
pp. 95-100 ◽  
Author(s):  
Shingo Suzuki ◽  
Masanori Kaneko ◽  
Donald C. Chapman ◽  
Naranjan S. Dhalla
Keyword(s):  
Free Radicals ◽  
Oxygen Free Radicals ◽  
Contractile Proteins ◽  
Cardiac Contractile ◽  
Cardiac Contractile Proteins
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