Antibodies to Acetaldehyde Adducts of Human Heart in Patients with Alcoholic Heart Muscle Disease

1993 ◽  
Vol 85 (s29) ◽  
pp. 36P-36P
Author(s):  
A Harcombe ◽  
J Koskinas ◽  
G Kenna ◽  
Hjf Why ◽  
PJ Richardson ◽  
...  
Keyword(s):  
Heart Muscle ◽  
Human Heart ◽  
Muscle Disease ◽  
Alcoholic Heart Muscle Disease

Alcoholic Heart Muscle Disease - a Reversible Entity

1991 ◽  
Vol 81 (s25) ◽  
pp. 16P-16P
Author(s):  
A J Jacob ◽  
K M McLaren ◽  
N A Boon
Keyword(s):  
Heart Muscle ◽  
Muscle Disease ◽  
Alcoholic Heart Muscle Disease

scholarly journals 799-5 Point Mutations of Mitochondrial DNA in Alcoholic Heart Muscle Disease

1995 ◽  
Vol 25 (2) ◽  
pp. 386A
Author(s):  
Masakazu Teragaki ◽  
Masahiko Takagi ◽  
Tomoko Tani ◽  
Minoru Yoshiyama ◽  
Iku Toda ◽  
...  
Keyword(s):  
Mitochondrial Dna ◽  
Heart Muscle ◽  
Point Mutations ◽  
Muscle Disease ◽  
Alcoholic Heart Muscle Disease

Effects of abstinence on alcoholic heart muscle disease

1991 ◽  
Vol 68 (8) ◽  
pp. 805-807 ◽  
Author(s):  
Ashok J. Jacob ◽  
Kathryn M. McLaren ◽  
Nicholas A. Boon
Keyword(s):  
Heart Muscle ◽  
Muscle Disease ◽  
Alcoholic Heart Muscle Disease

Testing Genetic Susceptibility Loci for Alcoholic Heart Muscle Disease

2001 ◽  
Vol 25 (10) ◽  
pp. 1409-1413 ◽  
Author(s):  
Olli A. Kajander ◽  
Markku Kupari ◽  
Markus Perola ◽  
Jarkko Pajarinen ◽  
Vesa Savolainen ◽  
...  
Keyword(s):  
Genetic Susceptibility ◽  
Heart Muscle ◽  
Muscle Disease ◽  
Susceptibility Loci ◽  
Alcoholic Heart Muscle Disease

Circulating Antibodies to Cardiac Protein—Acetaldehyde Adducts in Alcoholic Heart Muscle Disease

1995 ◽  
Vol 88 (3) ◽  
pp. 263-268 ◽  
Author(s):  
A. A. Harcombe ◽  
L. Ramsay ◽  
J. G. Kenna ◽  
J. Koskinas ◽  
H. J. F. Why ◽  
...  
Keyword(s):  
Heart Disease ◽  
Heart Muscle ◽  
Muscle Disease ◽  
Protein Antigens ◽  
Serum Samples ◽  
Igg Antibody ◽  
Western Immunoblotting ◽  
Molecular Sizes ◽  
Circulating Antibodies ◽  
Alcoholic Heart Muscle Disease

1. Serum samples from patients with alcoholic heart muscle disease and from control subjects with and without heart disease who did not drink to excess were screened by Western immunoblotting for antibodies to acetaldehyde-modified cardiac cytosolic proteins. 2. Two of the 64 control samples (from subjects with and without heart disease who were not drinking and from subjects with alcoholic liver disease) had detectable (IgG) antibody to acetaldehyde-modified cardiac proteins. 3. By contrast, 7 of 21 (33%) patients with alcoholic heart muscle disease had antibodies against cyanoborohydride-stabilized, acetaldehyde-modified human cardiac cytosolic protein antigens (P < 0.001). 4. Antibodies were of IgG class in six patients and IgA class in five. The molecular sizes of the protein antigens observed ranged from 58 to 120 kDa. 5. These results suggest that a proportion of patients with alcoholic heart muscle disease develop immunogenic cardiac protein—acetaldehyde adducts. The presence of antibodies to these adducts may be a marker for the diagnosis of this heart disease, or possibly for its pathogenesis.

A Rodent Model of Alcoholic Heart Muscle Disease and Its Evaluation by Echocardiography

2001 ◽  
Vol 25 (3) ◽  
pp. 457-463 ◽  
Author(s):  
Shann D. Kim ◽  
Jennifer Beck ◽  
Teresa Bieniarz ◽  
Autumn Schumacher ◽  
Mariann R. Piano
Keyword(s):  
Heart Muscle ◽  
Rodent Model ◽  
Muscle Disease ◽  
Alcoholic Heart Muscle Disease

Genetics of coxsackievirus B cardiovirulence and inflammatory heart muscle disease

1996 ◽  
Vol 4 (5) ◽  
pp. 175-179 ◽  
Author(s):  
Steven Tracy ◽  
Nora M. Chapman ◽  
José Romero ◽  
Arlene I. Ramsingh
Keyword(s):  
Heart Muscle ◽  
Muscle Disease ◽  
Coxsackievirus B
Sign in / Sign up

Export Citation Format

Share Document