Acute Neutral Endopeptidase Inhibition in Patients with Normal Glomerular Filtration Rate

1992 ◽  
Vol 83 (s27) ◽  
pp. 27P-27P
Author(s):  
GW Lipkin ◽  
ABS Dawnay ◽  
SM Harwood ◽  
WR Cattell ◽  
AEG Raine
Keyword(s):  
Glomerular Filtration Rate ◽  
Glomerular Filtration ◽  
Filtration Rate ◽  
Neutral Endopeptidase ◽  
Normal Glomerular Filtration Rate

Bone Modulating Factors in Nephrotic Children with Normal Glomerular Filtration Rate

PEDIATRICS ◽  
1985 ◽  
Vol 76 (2) ◽  
pp. 280-285
Author(s):  
Michael Freundlich ◽  
Jacques J. Bourgoignie ◽  
Gaston Zilleruelo ◽  
Allan I. Jacob ◽  
Janet M. Canterbury ◽  
...  
Keyword(s):  
Glomerular Filtration Rate ◽  
Glomerular Filtration ◽  
Filtration Rate ◽  
Vitamin D Metabolites ◽  
Hydroxyvitamin D ◽  
Dihydroxyvitamin D ◽  
25 Hydroxyvitamin D ◽  
Nephrotic Children ◽  
Normal Glomerular Filtration Rate ◽  
Immunoreactive Parathyroid Hormone

Factors influencing bone and mineral metabolism were evaluated in 16 children with active nephrotic syndrome and normal glomerular filtration rate. All patients were proteinuric and/or hypoalbuminemic and had elevated serum triglyceride and cholesterol levels. Seven patients had never received or had discontinued glucocorticoid treatment at least 6 months before the study; six patients were receiving prednisone at the time of study. Although all patients were hypocalcemic (serum total or ionized calcium), none was hypomagnesemic. Despite the low serum calcium levels, circulating immunoreactive parathyroid hormone was elevated in only nine of 16. Plasma 25-hydroxyvitamin D was low in all 16 patients, averaging 7.6 ± 1.2 ng/mL for the group. In contrast, levels of 1,25-dihydroxyvitamin D were normal in 12 of 14 patients. Bone mineral content measured by photon absorptiometry averaged 83% and was less than 90% of normal in six of nine patients tested. The findings were not influenced by the recent or concurrent administration of glucocorticoid. The data demonstrate abnormalities of mineral and bone modulation in nephrotic children even in the absence of impaired glomerular filtration rate and irrespective of glucocorticoid therapy. The decrease in serum ionized calcium may be related to an absolute deficiency in 25-hydroxyvitamin D and/or a relative deficiency in 1,25-dihydroxyvitamin D. Undermineralization of bone may result from the low levels of vitamin D metabolites and, in some patients, from an increase in immunoreactive parathyroid hormone. Whether treatment with vitamin D metabolites and/or calcium supplementation will prevent the abnormalities remains to be demonstrated.

Effects of a kinin antagonist on renal function in rats

1990 ◽  
Vol 258 (3) ◽  
pp. F643-F648
Author(s):  
M. Nakagawa ◽  
J. M. Stewart ◽  
R. J. Vavrek ◽  
A. Nasjletti
Keyword(s):  
Renal Function ◽  
Glomerular Filtration Rate ◽  
Glomerular Filtration ◽  
Plasma Flow ◽  
Sodium Excretion ◽  
Filtration Rate ◽  
Renal Plasma Flow ◽  
Combined Treatment ◽  
Neutral Endopeptidase ◽  
Kinin Receptor

We contrasted the effects of D-Arg-Arg-Pro-Hyp-Gly-Thi-Ser-DPhe-Thi-Arg-TFA (kinin receptor antagonist), of aprotinin (kallikrein inhibitor), and of combined treatment with captopril (kininase II inhibitor) and phosphoramidon (neutral endopeptidase 24.11 inhibitor) on renal function of rats with and without 14-day deoxycorticosterone pretreatment (DOC, 25 mg.kg-1.wk-1 sc). Neither the kinin antagonist nor aprotinin affected renal function in rats with and without DOC pretreatment. Combined treatment with captopril and phosphoramidon caused in rats with and without DOC pretreatment augmentation (P less than 0.05) of kinin excretion (50-64%), glomerular filtration rate (12-11%), and sodium excretion (46-48%). In DOC-pretreated rats undergoing infusion of captopril and phosphoramidon, the superimposed administration of either the kinin antagonist or aprotinin caused the lowering of renal plasma flow, glomerular filtration rate, and sodium excretion. These effects of the kinin antagonist and aprotinin in rats infused with kininase inhibitors may be the consequence of blockade, respectively, of the renal actions and synthesis of kinins that, when in excess, elicit renal vasodilation and increase glomerular filtration rate and sodium excretion. Collectively, these observations suggest regulatory influence of kinins during conditions featuring increased renal kinin levels.

scholarly journals 1594 INAPPROPRIATELY LOW PLASMA CALCITRIOL (CD IN CHILDREN WITH NEPHROTIC SYNDROME (NS) AND NORMAL GLOMERULAR FILTRATION RATE(GFR)

1985 ◽  
Vol 19 (4) ◽  
pp. 376A-376A
Author(s):  
Michael Freundllch ◽  
Jacques J Bourgolgnie ◽  
Gaston Zllleruelo ◽  
Carolyn Ahithol ◽  
Jose Strauss
Keyword(s):  
Nephrotic Syndrome ◽  
Glomerular Filtration Rate ◽  
Glomerular Filtration ◽  
Filtration Rate ◽  
Normal Glomerular Filtration Rate

scholarly journals Activity of lysosomal urine enzymes in children after acute kidney injury

2019 ◽  
pp. 31-39
Author(s):  
I.V. Bagdasrova ◽  
L.V. Korol ◽  
O.V. Lavrenchuk ◽  
L.Ya. Migal
Keyword(s):  
Acute Kidney Injury ◽  
Glomerular Filtration Rate ◽  
Glomerular Filtration ◽  
Interstitial Nephritis ◽  
Lysosomal Enzymes ◽  
Filtration Rate ◽  
Reference Group ◽  
Kidney Injury ◽  
History Of ◽  
Normal Glomerular Filtration Rate

 The importance of the problem of acute kidney injury in children is due to the high risk of developing chronic kidney disease as a consequence. Lysosomal enzymes of β-galactosidase (GAL) and N-acetyl-β-D-hexozoaminidase (NAG) in urine are considered to be informative markers of renal parenchyma damage. The objective of this study - to determine the activity of lysosomal enzymes in urine as markers of progression of interstitial nephritis in children after acute kidney injury. Methods. 41 children were examined after acute kidney injury, achievement of self-diuresis and improvement. Group I included 22 patients with a disease period of up to 2 years after acute kidney injury, group II - 19 patients with a disease period of 2 years or more. The control (reference) group consisted of 28 children who were conditionally healthy, without kidney disease, as well as without acute diseases and severe metabolic disorders and anatomical defects. Results. NAG and GAL activity were found to exceed 8 and 3 times parameters in the reference group of healthy children, respectively, in patients who had acute kidney injury during the year (p <0.001). In patients with a history of 2 years or more, enzyme levels decreased, but remained higher than normal up to 4 times (p <0.001). The highest level of NAG activity was observed in patients of group 1 with the combination of hemolytic-uremic syndrome with hemolytic anemia, and the lowest - in children with toxic kidney. Determination of the activity of lysosomal enzymes NAG and GAL is a more informative marker of torpid course of interstitial nephritis with a progressive decrease in renal function than indicators of glomerular filtration rate. In twelve months after acute kidney damage in 75% of children, the level of NAG and GAL activity remained significantly elevated at normal glomerular filtration rate. A correlation between glomerular filtration rate and NAG activity (r = -0.473) and GAL (r = -0.333) and a direct correlation between NAG and GAL activity (r = 0.845) were observed. Conclusions. The levels of lysosomal enzymes of NAG and GAL were found to be 8 and 3 times higher than normal, respectively, in patients who suffered acute kidney injury during the year, and in patients with a history of 2 years or more, enzyme activity levels decreased, but remained higher than normal 4-fold (p <0.001). In a year after acute kidney damage in 75% of children, the level of NAG and GAL activity remained significantly elevated despite of normal glomerular filtration rate. Therefore, the detection of NAG and β-galactosidase in the urine of children after acute kidney injury are informative markers of renal parenchyma damage, which may serve as objective criteria for progressive decline in renal functional status, and the lack of normalization of their levels is not a sign of progression of interstitial nephritis in corresponding group of children.

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