Raised resting energy expenditure in Parkinson's disease and its relationship to muscle rigidity

1992 ◽  
Vol 83 (2) ◽  
pp. 199-204 ◽  
Author(s):  
H. S. Markus ◽  
M. Cox ◽  
A. M. Tomkins
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Energy Expenditure ◽  
Matched Control ◽  
Resting Energy Expenditure ◽  
Muscle Rigidity ◽  
Control Subjects ◽  
Treated State ◽  
Made In ◽  
Resting Energy

1. Resting energy expenditure was measured, by indirect calorimetry, in 12 patients with Parkinson's disease and in eight healthy age-matched control subjects. In the patients with Parkinson's disease measurements were made in both the untreated state and after an injection of the dopamine agonist apomorphine (treated state). In each state muscle rigidity was recorded. 2. Resting energy expenditure was higher in patients with Parkinson's disease in both the treated and untreated states than in the control subjects. Of the patients with Parkinson's disease, seven showed no difference in resting energy expenditure between the two treatment states, whereas four showed markedly increased resting energy expenditure in the untreated state. The change in resting energy expenditure in the untreated state, as compared with the treated state, was significantly related to the development of muscle rigidity in the untreated state. 3. In Parkinson's disease, even in optimally treated patients, resting energy expenditure is raised and this may contribute to the weight loss seen in this disease. Severe muscle rigidity occurring during untreated periods results in a further increase in resting energy expenditure.

Resting energy expenditure in Parkinson’s disease patients under dopaminergic treatment

2020 ◽  
pp. 1-10
Author(s):  
Michela Barichella ◽  
Emanuele Cereda ◽  
Samanta Andrea Faierman ◽  
Gabriele Piuri ◽  
Carlotta Bolliri ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Energy Expenditure ◽  
Resting Energy Expenditure ◽  
Resting Energy

RESTING ENERGY EXPENDITURE IN PARKINSON'S DISEASE PATIENTS UNDER DOPAMINERGIC TREATMENT

Nutrition ◽  
2020 ◽  
Vol 75-76 ◽  
pp. 110913
Author(s):  
E. Cereda ◽  
M. Barichella ◽  
C. Bolliri ◽  
S. Caronni ◽  
E. Cassani ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Energy Expenditure ◽  
Resting Energy Expenditure ◽  
Resting Energy

scholarly journals Compensatory stepping in Parkinson's disease is still a problem after deep brain stimulation randomized to STN or GPi

2015 ◽  
Vol 114 (3) ◽  
pp. 1417-1423 ◽  
Author(s):  
R. J. St George ◽  
P. Carlson-Kuhta ◽  
L. A. King ◽  
K. J. Burchiel ◽  
F. B. Horak
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Deep Brain Stimulation ◽  
Brain Stimulation ◽  
Step Response ◽  
Pd Control ◽  
Control Subjects ◽  
Compensatory Stepping ◽  
Treated State ◽  
Deep Brain

The effects of deep brain stimulation (DBS) on balance in people with Parkinson's disease (PD) are not well established. This study examined whether DBS randomized to the subthalamic nucleus (STN; n = 11) or globus pallidus interna (GPi; n = 10) improved compensatory stepping to recover balance after a perturbation. The standing surface translated backward, forcing subjects to take compensatory steps forward. Kinematic and kinetic responses were recorded. PD-DBS subjects were tested off and on their levodopa medication before bilateral DBS surgery and retested 6 mo later off and on DBS, combined with off and on levodopa medication. Responses were compared with PD-control subjects ( n = 8) tested over the same timescale and 17 healthy control subjects. Neither DBS nor levodopa improved the stepping response. Compensatory stepping in the best-treated state after surgery (DBS+DOPA) was similar to the best-treated state before surgery (DOPA) for the PD-GPi group and the PD-control group. For the PD-STN group, there were more lateral weight shifts, a delayed foot-off, and a greater number of steps required to recover balance in DBS+DOPA after surgery compared with DOPA before surgery. Within the STN group five subjects who did not fall during the experiment before surgery fell at least once after surgery, whereas the number of falls in the GPi and PD-control groups were unchanged. DBS did not improve the compensatory step response needed to recover from balance perturbations in the GPi group and caused delays in the preparation phase of the step in the STN group.

scholarly journals Impairments in Deductive Reasoning and Working Memory in Parkinson’s Disease

1997 ◽  
Vol 10 (1) ◽  
pp. 1-8 ◽  
Author(s):  
Shelley Channon
Keyword(s):  
Parkinson’S Disease ◽  
Working Memory ◽  
Parkinson's Disease ◽  
Deductive Reasoning ◽  
Matched Control ◽  
Memory Updating ◽  
Strategic Processing ◽  
Control Subjects

This study was designed to investigate the nature and extent of executive impairments in medicated subjects with Parkinson's disease (PD) and matched control subjects. They performed two tasks involving strategic processing, deductive reasoning and memory updating. PD patients differed significantly from controls in solving two- and four-dimensional deductive reasoning problems, and they also showed impairment in memory updating. The findings are discussed in relation to previous studies which have shown deficits in strategic processing in PD.

scholarly journals Increased energy expenditure in hemodialysis patients.

1996 ◽  
Vol 7 (12) ◽  
pp. 2646-2653
Author(s):  
T A Ikizler ◽  
R L Wingard ◽  
M Sun ◽  
J Harvell ◽  
R A Parker ◽  
...  
Keyword(s):  
Energy Expenditure ◽  
Respiratory Quotient ◽  
Resting Energy Expenditure ◽  
Hemodialysis Patients ◽  
Chronic Hemodialysis ◽  
Multiple Factors ◽  
Control Subjects ◽  
Protein Calorie Malnutrition ◽  
Resting Energy

Malnutrition is prevalent in chronic hemodialysis patients and is related to multiple factors; the hemodialysis procedure itself has been suggested as a catabolic factor. To examine the possible role of hemodialysis on energy metabolism, resting energy expenditure and respiratory quotient in ten chronic hemodialysis patients was measured in this study, using a whole-room indirect calorimeter. Measurements were done continuously: for 2 h before hemodialysis, during 4 h of hemodialysis, for 2 h after hemodialysis, and separately on a nondialysis day after 12 h of fasting. Age-, sex-, and body mass index-matched healthy volunteers were used as control subjects. Chronic hemodialysis patients have a significantly higher resting energy expenditure on a nondialysis day (1.18 +/- 0.15 kcal/min; P < 0.01) as compared with control subjects (1.10 +/- 0.16 kcal/ min). Resting energy expenditure further increased significantly during the hemodialysis procedure (1.32 +/- 0.18 kcal/min, averaged over the 4 h of hemodialysis; P < 0.01 versus predialysis) and was also significantly higher compared with the postdialysis period and nondialysis day resting energy expenditure (P < 0.001 for both). This effect was most pronounced during the first (1.37 +/- 0.19 kcal/min) and second (1.33 +/- 0.18 kcal/min) hours of hemodialysis (P < 0.001 for both). Respiratory quotient was not significantly affected by hemodialysis. It was concluded that chronic hemodialysis patients have higher than normal resting energy expenditure levels, which is further increased during hemodialysis. This process may significantly potentiate the protein-calorie malnutrition seen in this patient population.

Increased resting energy expenditure in cystic fibrosis

1988 ◽  
Vol 64 (5) ◽  
pp. 1810-1816 ◽  
Author(s):  
R. M. Buchdahl ◽  
M. Cox ◽  
C. Fulleylove ◽  
J. L. Marchant ◽  
A. M. Tomkins ◽  
...  
Keyword(s):  
Cystic Fibrosis ◽  
Energy Expenditure ◽  
Resting Energy Expenditure ◽  
Forced Expiratory Volume ◽  
Whole Body ◽  
Clinical State ◽  
Control Subjects ◽  
Blood Leukocyte ◽  
Poor Pulmonary Function ◽  
Resting Energy

To explore the hypothesis that there is an increased metabolic rate in cystic fibrosis, resting energy expenditure was measured by indirect calorimetry in 23 subjects with cystic fibrosis in a stable clinical state and in 42 normal control subjects. Resting energy expenditure was found to be elevated by an average of 0.45 MJ/24 h [95% confidence interval (CI) = 0.26–0.64, t = 4.91, P less than 0.001] (108 kcal/24 h), or 9.2% above expected values derived from the regression relating resting energy expenditure to whole body weight and sex in control subjects. When related to lean body mass, values were still elevated by 0.36 MJ/24 h (95% CI = 0.18–0.53, t = 4.15, P less than 0.001) (86 kcal/24 h), or 7.2%. The increased values were found to be independent of age, sex, or body size. There were significant correlations between increased values and poor pulmonary function as measured by the ratio of the forced expiratory volume in 1 s to forced vital capacity (r = -0.44, P less than 0.05) and subclinical infection as indicated by the blood leukocyte count (r = 0.40, P less than 0.05). However, the correlations were low, suggesting that other factors may contribute to the increased resting energy expenditure, possibly including the putative metabolic defect in cystic fibrosis.

scholarly journals Swallowing in Parkinson Patients versus Healthy Controls: Reliability of Measurements in Videofluoroscopy

2011 ◽  
Vol 2011 ◽  
pp. 1-9 ◽  
Author(s):  
Laura W. J. Baijens ◽  
Renée Speyer ◽  
Valéria Lima Passos ◽  
Walmari Pilz ◽  
Nel Roodenburg ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Interrater Reliability ◽  
Matched Control ◽  
Healthy Controls ◽  
Swallowing Function ◽  
Age And Gender ◽  
Control Subjects ◽  
Healthy Control ◽  
And Gender

Objective. To determine and describe the pathophysiological aspects of oropharyngeal swallowing in patients with Parkinson's disease more accurately, a pilot study of qualitative as well as quantitative parameters of swallowing was performed using videofluoroscopy (VFS).Methods. Ten patients with a diagnosis of idiopathic Parkinson's disease having dysphagic complaints and ten healthy age- and gender-matched control subjects underwent a standardized videofluoroscopic swallowing protocol. Information on the swallowing function was derived from temporal, spatial, and descriptive visuoperceptual parameters. Intra- and interrater reliability was calculated.Results. No significant differences were found between Parkinson patients and healthy control subjects for the majority of the reliable variables.Conclusions. It was concluded that swallowing function seemed to be preserved in the early stages of Parkinson's disease. Furthermore, the reliability of many quantitative as well as qualitative swallowing parameters proved insufficient, raising questions about the interpretation of study outcomes in videofluoroscopy.

scholarly journals Facial Expressions and Parkinson’s Disease

1995 ◽  
Vol 8 (2) ◽  
pp. 115-119 ◽  
Author(s):  
P. Madeley ◽  
A. W. Ellis ◽  
R. H. S. Mindham
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Facial Expressions ◽  
Face Processing ◽  
Matched Control ◽  
Control Subjects ◽  
Significant Difference ◽  
Healthy Control ◽  
Facial Expressiveness

Patients with Parkinson's disease (PD) and matched control subjects were photographed posing a range of facial expressions. The same subjects were later asked to identify the posed expressions of the other subjects. They were also asked to rate the quality of expressions posed by the control subjects after being told what each expression was. Expressions posed by healthy control subjects were more readily identifiable than expressions posed by Parkinson's patients, but the two groups did not differ in their ability to recognize facial expressions or in the goodness ratings they gave, and their error patterns were closely similar. There was no significant difference between the groups on other tests of face processing or on ratings of emotionality except for greater reported anxiety in the Parkinson's patients. We conclude that although patients with PD have reduced facial expressiveness, there is no apparent diminution in their comprehension of facial expressions or their day-to-day experience of emotion.

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