Atherogenic Lipid Profiles Occur in Type 2 (Non-Insulin Dependent) Diabetic Patients with “Acceptable” Concentrations of Total Plasma Cholesterol and Triglycerides

1992 ◽  
Vol 82 (s26) ◽  
pp. 40P-40P
Author(s):  
MW Stewart ◽  
MF Laker ◽  
RG Dyer ◽  
F Game ◽  
J Mitcheson ◽  
...  
Keyword(s):  
Plasma Cholesterol ◽  
Lipid Profiles ◽  
Diabetic Patients ◽  
Total Plasma Cholesterol ◽  
Total Plasma ◽  
Insulin Dependent ◽  
Insulin Dependent Diabetic ◽  
Atherogenic Lipid

scholarly journals A controlled trial of a high fibre, low fat and low sodium diet for mild hypertension in type 2 (non-insulin-dependent) diabetic patients

Diabetologia ◽  
1984 ◽  
Vol 27 (5) ◽  
pp. 522-526 ◽  
Author(s):  
P. M. Dodson ◽  
P. J. Pacy ◽  
P. Bal ◽  
A. J. Kubicki ◽  
R. F. Fletcher ◽  
...  
Keyword(s):  
Mild Hypertension ◽  
Controlled Trial ◽  
Diabetic Patients ◽  
Low Fat ◽  
Low Sodium Diet ◽  
Low Sodium ◽  
High Fibre ◽  
Insulin Dependent ◽  
Insulin Dependent Diabetic

scholarly journals Cellular and humoural autoimmunity markers in Type 2 (non-insulin-dependent) diabetic patients with secondary drug failure

Diabetologia ◽  
1992 ◽  
Vol 35 (12) ◽  
pp. 1159-1164 ◽  
Author(s):  
A. V. Zavala ◽  
L. E. Fabiano de Bruno ◽  
A. I. Cardoso ◽  
A. H. Mota ◽  
M. Capucchio ◽  
...  
Keyword(s):  
Diabetic Patients ◽  
Insulin Dependent ◽  
Secondary Drug Failure ◽  
Insulin Dependent Diabetic

Cholesterol feeding exacerbates myocardial injury in Zucker diabetic fatty rats

2000 ◽  
Vol 278 (1) ◽  
pp. H256-H262 ◽  
Author(s):  
Shiro Hoshida ◽  
Nobushige Yamashita ◽  
Kinya Otsu ◽  
Tsunehiko Kuzuya ◽  
Masatsugu Hori
Keyword(s):  
Infarct Size ◽  
Myocardial Injury ◽  
Coronary Occlusion ◽  
Plasma Cholesterol ◽  
Diabetic Rats ◽  
Total Plasma Cholesterol ◽  
Total Plasma ◽  
Cholesterol Feeding ◽  
Insulin Dependent ◽  
Zdf Rats

We measured infarct size after coronary occlusion (30 min) and reperfusion (24 h) in genetic non-insulin-dependent Zucker diabetic fatty (ZDF) rats with and without 4-wk cholesterol feeding. Infarct size was similar in ZDF rats and lean control rats but was significantly larger in cholesterol-fed diabetic rats than in cholesterol-fed lean rats ( P < 0.05). Plasma levels of glucose, insulin, and triglycerides were significantly higher in diabetic rats and were not influenced by cholesterol feeding. The increase in total plasma cholesterol induced by cholesterol feeding was significantly greater in diabetic rats than in lean rats ( P < 0.05). A significant positive correlation was found between total plasma cholesterol and infarct size ( P < 0.05). Myeloperoxidase activity, as an index of neutrophil accumulation, was significantly higher and expression of P-selectin was more marked in the ischemic myocardium of cholesterol-fed diabetic rats than of cholesterol-fed lean rats. Acetylcholine-induced endothelium-dependent relaxation (EDR) of aortic rings was markedly impaired in cholesterol-fed diabetic rats. Thus cholesterol feeding significantly exacerbated myocardial injury produced by coronary occlusion-reperfusion in non-insulin-dependent diabetic rats, possibly because of enhanced expression of P-selectin and impairment of EDR in the coronary bed.

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