Nebulised Diamorphine Increases Maximal Exercise Capacity in Chronic Left Ventricular Failure

1991 ◽  
Vol 80 (s24) ◽  
pp. 24P-24P
Author(s):  
NG Uren ◽  
SW Davies ◽  
SL Jordan ◽  
DP Lipkin
Keyword(s):  
Exercise Capacity ◽  
Maximal Exercise ◽  
Left Ventricular ◽  
Left Ventricular Failure ◽  
Ventricular Failure ◽  
Maximal Exercise Capacity

Maximal exercise capacity and oxygen consumption of lambs with an aortopulmonary left-to-right shunt

1990 ◽  
Vol 69 (4) ◽  
pp. 1479-1485 ◽  
Author(s):  
J. W. Gratama ◽  
J. J. Meuzelaar ◽  
M. Dalinghaus ◽  
J. H. Koers ◽  
A. J. Werre ◽  
...  
Keyword(s):  
Oxygen Consumption ◽  
Exercise Capacity ◽  
Maximal Exercise ◽  
Left Ventricular ◽  
Peak Oxygen Consumption ◽  
Systemic Blood ◽  
Systemic Blood Flow ◽  
Ventricular Performance ◽  
Left Ventricular Output ◽  
Maximal Exercise Capacity

We determined maximal exercise capacity and measured hemodynamics in 10 6-wk-old lambs with an aortopulmonary left-to-right shunt [S, 57 +/- 11%, (SD)] and in 9 control lambs (C) during a graded treadmill test 8 days after surgery. Maximal exercise capacity (3.7 +/- 0.2 km/h and 10 +/- 5% inclination vs. 4.0 +/- 0.9 km/h and 15 +/- 0% inclination, P less than 0.02) and peak oxygen consumption (25 +/- 7 vs. 34 +/- 8 ml O2.min-1.kg-1, P less than 0.02) were both lower in the shunt than in the control lambs. This was due to a lower maximal systemic blood flow in the shunt lambs (271 +/- 38 vs. 359 +/- 71 ml.min-1.kg-1, P less than 0.01). Despite their high maximal left ventricular output, which was higher than in the control lambs (448 +/- 87 vs. 359 +/- 71 ml.min-1.kg-1, P less than 0.05), the left-to-right shunt could not be compensated for during maximal exercise because of a decreased reserve in heart rate (S: 183 +/- 22 to 277 +/- 38 beats/min; C: 136 +/- 25 to 287 +/- 29 beats/min) and in left ventricular stroke volume (S: 1.8 +/- 0.3 to 1.6 +/- 0.4 ml/kg; C: 1.0 +/- 0.3 to 1.3 +/- 0.2 ml/kg). We conclude that exercise capacity of shunt lambs is lower than that of control lambs, despite a good left ventricular performance, because a part of the reserves for increasing the left ventricular output is already utilized at rest.

scholarly journals Cardiovascular risk associated with long-term anabolic-androgenic steroid abuse: an observational study from Norway

2021 ◽  
Vol 42 (Supplement_1) ◽  
Author(s):  
T Saetereng ◽  
P Vanberg ◽  
K Steine ◽  
D Atar ◽  
S Halvorsen
Keyword(s):  
Exercise Capacity ◽  
Ventricular Arrhythmias ◽  
Maximal Exercise ◽  
Left Ventricular ◽  
Control Group ◽  
User Group ◽  
Exercise Ecg ◽  
Cardiovascular Evaluation ◽  
Maximal Exercise Capacity

Abstract Background The use of anabolic-androgenic steroids (AAS) has become highly prevalent among recreational weightlifters. Numerous case reports have suggested an association between AAS use and a vast range of different cardiovascular diseases, including sudden cardiac death (SCD) and coronary artery disease (CAD). Few clinical studies have evaluated the risk of SCD and the prevalence of CAD in individuals with long-term AAS use. Purpose To evaluate the risk of ventricular arrhythmias and the prevalence of CAD among men with long-term AAS use. Methods Strength-trained men with at least three years of cumulative AAS use were recruited from recreational gyms. The control group consisted of strength-trained competing athletes who self-reported never using any performance enhancing drugs (non-users). AAS use was verified by sophisticated blood and urine analyses. Study participants went through a comprehensive cardiovascular evaluation including exercise ECG, 24 h ECG, heart rate variability (HRV) measures, signal averaged ECG (SAECG) and QT dispersion (QTd). Coronary computed tomography angiography (CCTA) was performed in AAS users. Not all participants had all tests. Results We included 51 AAS users and 21 non-users. Median age (25th-75th percentile) was 33 (29–37) years in the user group and 33 (29–42) years in the non-user group. Forty-eight (94%) of the users had been using AAS for five years or more. Characteristics are presented in the table. AAS users had significantly lower HDL values compared to non-users (p<0.001). No signs of ischemia or arrhythmias were detected during exercise ECG, however maximal exercise capacity was lower than in the control group and also compared to age-standardized values. A considerable, but statistically non-significant reduction was seen in overall HRV estimated as the standard deviation of the RR intervals for normal sinus beats (SDNN) (p=0.05). No difference was seen regarding left ventricular late potentials or QTd (table). Eight (19%) of the forty-two AAS users undergoing CCTA had at least a mild degree of CAD, and four of them three-vessel disease. Conclusion No ECG-findings indicated an increased risk of ventricular arrhythmias among the long-term AAS users. However, their maximal exercise capacity was lower than in controls, and one fifth of the long-term AAS users had verified CAD on CT coronary angiography. FUNDunding Acknowledgement Type of funding sources: None. Table 1

scholarly journals Left ventricular regional function and maximal exercise capacity in aortic stenosis

2015 ◽  
Vol 17 (2) ◽  
pp. 217-224 ◽  
Author(s):  
R. Dulgheru ◽  
J. Magne ◽  
L. Davin ◽  
A. Nchimi ◽  
C. Oury ◽  
...  
Keyword(s):  
Aortic Stenosis ◽  
Exercise Capacity ◽  
Maximal Exercise ◽  
Left Ventricular ◽  
Regional Function ◽  
Maximal Exercise Capacity
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