Non-Invasive Assessment of the Cardiovascular Eicosanoids, Thromboxane A2 and Prostacyclin, in Randomly Sampled Males, with Special Reference to the Influence of Inheritance and Environmental Factors

1990 ◽  
Vol 79 (6) ◽  
pp. 639-645 ◽  
Author(s):  
Å. Wennmalm ◽  
G. Benthin ◽  
K. Caidahl ◽  
E. F. Granström ◽  
B. Lanne ◽  
...  
Keyword(s):  
Environmental Factors ◽  
Vessel Wall ◽  
Acute Infection ◽  
Young Men ◽  
Thromboxane A2 ◽  
Platelet Activity ◽  
Recent Infection ◽  
Trained Subjects ◽  
Non Invasive ◽  
Noradrenaline And Adrenaline

1. We studied, in a random sample of 385 nonsmoking men born in 1968–1969 and 31 men born in 1913 or 1923, whether inheritance and environmental factors influenced platelet activity and vessel wall prostacyclin formation, as reflected non-invasively by the urinary excretion of the 2,3-dinor-metabolites of thromboxane A2 (2,3-dinor-thromboxane B2, Tx-M) and prostacyclin (2,3-dinor-6-keto-prostaglandin F1α, PGI-M), respectively. 2. Fathers of young men with high platelet activity did not excrete more Tx-M than fathers of young men with low platelet activity. Men born in 1913 or 1923 displayed higher Tx-M (563 versus 128 pg/mg of creatinine, P < 0.001) and PGI-M (163 versus 130 pg/mg of creatinine, P < 0.01) excretion than those born in 1968–1969. Excretion of both Tx-M and PGI-M was correlated to the urinary output of noradrenaline and adrenaline. 3. Well-trained subjects did not differ in their excretion of Tx-M or PGI-M from those who did not exercise regularly. A recent acute infection was also unrelated to the excretion of Tx-M or PGI-M. PGI-M excretion was, however, significantly correlated to Tx-M excretion (r = 0.51, P < 0.001). 4. This study provides the first non-invasive evidence that advancing age and sympathoadrenal tone are positively correlated to platelet activity in randomly sampled men, and that paternal inheritance, physical fitness and recent infection lack correlation to platelet activity.

Cigarette smoking and urinary excretion of markers for platelet/vessel wall interaction in healthy women

1991 ◽  
Vol 81 (1) ◽  
pp. 11-15 ◽  
Author(s):  
C. Rångemark ◽  
Å. Wennmalm
Keyword(s):  
Cigarette Smoking ◽  
Urinary Excretion ◽  
Platelet Activation ◽  
Vessel Wall ◽  
Thromboxane A2 ◽  
Epidemiological Studies ◽  
Thromboxane B2 ◽  
Platelet Activity ◽  
Healthy Women ◽  
Wall Interaction

1. Cigarette smoking is known to increase the risk of cardiovascular disease in both men and women. Experimental and epidemiological studies have demonstrated that cigarette smoking is associated with several indices of increased platelet activation and platelet/vessel wall interaction in men. The aim of the present study was to test the hypothesis that cigarette smoking is linked to an increased platelet activity in women also. 2. In 26 healthy smoking and non-smoking women (age 21–49 years) the urinary excretion of the thromboxane A2 metabolite 2,3-dinor-thromboxane B2 (an index of platelet activation) and of the prostacyclin metabolite 2,3-dinor-6-keto-prostaglandin F1α (an index of platelet/vessel wall interaction) were analysed by g.c.-m.s. in samples collected on days 3, 10 and 20 of their respective menstrual cycles. 3. The urinary excretion of 2,3-dinor-thromboxane B2 did not vary significantly during the menstrual cycle, either in the smokers or in the non-smokers. It was consistently higher (P < 0.004) in the group of smokers (average of days 3, 10 and 20, 395 ± 61 pg/mg of creatinine; mean ± sem) than in the group of non-smokers (average 188 ± 22 pg/mg of creatinine). 4. The urinary excretion of 2,3-dinor-6-keto-prostaglandin F1α did not differ between the groups on any of the days studied (average on days 3, 10 and 20 in the smokers and non-smokers was 281 ± 50 and 227 ± 30 pg/mg of creatinine, respectively). 5. These data demonstrate that smoking fertile women excrete more of the thromboxane A2 metabolite than do non-smokers, thereby supporting the hypothesis that cigarette smoking elicits platelet activation in healthy women. In contrast, platelet/vessel wall interaction does not appear to be facilitated in smoking compared with non-smoking women. The data suggest that platelet activation is not a major haemostatic mechanism during menstruation.

Cigarette Smoking Increases Thromboxane A2 Formation without Affecting Platelet Survival in Young Healthy Females

1992 ◽  
Vol 68 (05) ◽  
pp. 583-588 ◽  
Author(s):  
Annika Dotevall ◽  
Christina Rångemark ◽  
Elsa Eriksson ◽  
Jack Kutti ◽  
Hans Wadenvik ◽  
...  
Keyword(s):  
Cardiovascular Disease ◽  
Cigarette Smoking ◽  
Blood Cell ◽  
Urinary Excretion ◽  
Life Span ◽  
Cell Count ◽  
Thromboxane A2 ◽  
Blood Cell Count ◽  
Platelet Activity ◽  
Pai 1

SummarySmoking is a risk factor for the development of atherosclerotic cardiovascular disease, in men as well as in women. An increased urinary excretion of the thromboxane metabolite 2,3-dinor-thromboxane B2 (Tx-M) has been observed in smokers of both genders, suggesting that cigarette smoking may facilitate cardiovascular disease via an action on the platelets. The present study addressed the hypothesis that the increased Tx-M excretion in female smokers reflects a true facilitation of platelet reactivity in vivo, rather than an increased destruction of the platelets. In healthy female volunteers (aged 20–46 years, 18 smokers and 17 non-smokers) platelet life-span and indices of platelet activity were determined, together with plasma levels of plasminogen activator inhibitor-1 (PAI-1), fibrinogen, peripheral blood cell counts and hematocrit. The urinary excretion of Tx-M was higher in smokers than in non-smokers (361 vs. 204 pg/mg creatinine, respectively, p <0.05), while plasma and urinary β-thromboglobulin, plasma platelet factor 4, platelet mean life-span and platelet production rate did not differ between the groups. PAI-1 activity, white blood cell count and hematocrit were higher in smokers than in non-smokers (p <0.05). These data indicate that smoking facilitates platelet formation of thromboxane A2 without affecting platelet survival; i.e. it increases the activity of platelets without affecting their viability to a measurable extent. Such an increase in platelet activity, operating in parallel to a reduced fibrinolytic activity and a higher hematocrit and white blood cell count, may play an etiological role in smoking-induced cardiovascular disease in women.

scholarly journals Mammary Gland Pathology Subsequent to Acute Infection with Strong versus Weak Biofilm Forming Staphylococcus aureus Bovine Mastitis Isolates: A Pilot Study Using Non-Invasive Mouse Mastitis Model

PLoS ONE ◽  
2017 ◽  
Vol 12 (1) ◽  
pp. e0170668 ◽  
Author(s):  
Jully Gogoi-Tiwari ◽  
Vincent Williams ◽  
Charlene Babra Waryah ◽  
Paul Costantino ◽  
Hani Al-Salami ◽  
...  
Keyword(s):  
Staphylococcus Aureus ◽  
Mammary Gland ◽  
Pilot Study ◽  
Acute Infection ◽  
Bovine Mastitis ◽  
Non Invasive

scholarly journals Acute melioidosis outbreak in Western Australia

1999 ◽  
Vol 123 (3) ◽  
pp. 437-443 ◽  
Author(s):  
T. J. J. INGLIS ◽  
S. C. GARROW ◽  
C. ADAMS ◽  
M. HENDERSON ◽  
M. MAYO ◽  
...  
Keyword(s):  
Environmental Factors ◽  
Water Supply ◽  
Western Australia ◽  
Burkholderia Pseudomallei ◽  
Acute Infection ◽  
Exposure Period ◽  
Pfge Type ◽  
Chromosomal Dna ◽  
Potable Water Supply

A cluster of acute melioidosis cases occurred in a remote, coastal community in tropical Western Australia. Molecular typing of Burkholderia pseudomallei isolates from culture-confirmed cases and suspected environmental sources by pulsed-field gel electrophoresis (PFGE) of XbaI chromosomal DNA digests showed that a single PFGE type was responsible for five cases of acute infection in a community of around 300 during a 5 week period. This temporal and geographical clustering of acute melioidosis cases provided a unique opportunity to investigate the environmental factors contributing to this disease. B. pseudomallei isolated from a domestic tap at the home of an asymptomatic seroconverter was indistinguishable by PFGE. Possible contributing environmental factors included an unusually acid communal water supply, unrecordable chlorine levels during the probable exposure period, a nearby earth tremor, and gusting winds during the installation of new water and electricity supplies. The possible role of the potable water supply as a source of B. pseudomallei was investigated further.

scholarly journals Increasing corvid tolerance to humans in urban ecosystems with increasing latitude

2020 ◽  
Vol 64 (4) ◽  
Author(s):  
Nadezhda Poddubnaya ◽  
Tatyana Korotkova ◽  
Polina Vanicheva
Keyword(s):  
Environmental Factors ◽  
Human Disturbance ◽  
Urban Ecosystems ◽  
Flight Initiation Distance ◽  
Protection Measures ◽  
Non Invasive ◽  
Alert Distance ◽  
Behaviour Changes ◽  
Hooded Crows ◽  
Flight Initiation

The rapid growth of cities causes behaviour changes in birds in response to urban environmental factors. The avian response to human disturbance has recently been studied by a non-invasive research tool as an alert distance (AD) and a flight initiation distance (FID) assessment. The tolerance of hooded crows (n = 395), jackdaws (n = 394) and rooks (n = 169) to humans was assessed by AD and FID. It was shown that the FID of all species is maximal during the summer, when the parents send clear “danger—fly away” signals to the young and the birds fly away. The AD and FID of the three species reliably correlates with the season. Rooks showed FID species-specificity in seven cities of Eastern Europe. Comparison of the attitude of birds to people in cities that have similarities in human culture showed that tolerance increases with increasing latitude in all species and is statistically significant only in the jackdaw. This should be taken into account in environmental protection measures.

scholarly journals The effect of vascular diseases on bioimpedance measurements: mathematical modeling

2018 ◽  
Vol 5 (6) ◽  
Author(s):  
Yomna H. Shash ◽  
Mohamed A. A. Eldosoky ◽  
Mohamed T. Elwakad
Keyword(s):  
Mathematical Models ◽  
Vessel Wall ◽  
Vascular Diseases ◽  
Impedance Analysis ◽  
Wide Field ◽  
Vascular Disorders ◽  
Non Invasive ◽  
Novel Method ◽  
Inner Vessel ◽  
Arteries And Veins

Introduction: The non-invasive nature of bioimpedance technique is the reason for the adoption of this technique in the wide field of bio-research. This technique is useful in the analysis of a variety of diseases and has many advantages. Cardiovascular diseases are the most dangerous diseases leading to death in many regions of the world. Vascular diseases are disorders that affect the arteries and veins. Most often, vascular diseases have greater impacts on the blood flow, either by narrowing or blocking the vessel lumen or by weakening the vessel wall. The most common vascular diseases are atherosclerosis, wall swelling (aneurysm), and occlusion. Atherosclerosis is a disease caused by the deposition of plaques on the inner vessel wall, while a mural aneurysm is formed as a result of wall weakness. The main objective of this study was to investigate the effects of vascular diseases on vessel impedance. Furthermore, this study aimed to develop the measurement of vessel abnormalities as a novel method based on the bioimpedance phenomenon. Methods: Mathematical models were presented to describe the impedance of vessels in different vascular cases. In addition, a 3D model of blood vessels was simulated by COMSOL MULTIPHYSICS.5, and the impedance was measured at each vascular condition. Results: The simulation results clarify that the vascular disorders (stenosis, blockage or aneurysm) have significant impact on the vessel impedance, and thus they can be detected by using the bio-impedance analysis. Moreover, using frequencies in KHz range is preferred in detecting vascular diseases since it has the ability to differentiate between the healthy and diseased blood vessel. Finally, the results can be improved by selecting an appropriate electrodes configuration for analysis. Conclusion: From this work, it can be concluded that bioimpedance analysis (BIA) has the ability to detect vascular diseases. Furthermore, the proposed mathematical models are successful at describing different cases of vascular disorders.

Diabetic Retinopathy And Thromboxane Like Substance

1981 ◽  
Author(s):  
M A Lazzari ◽  
M Gimeno ◽  
N M Sutton ◽  
J R Lopez
Keyword(s):  
Diabetes Mellitus ◽  
Arachidonic Acid ◽  
Diabetic Retinopathy ◽  
Risk Factor ◽  
Platelet Aggregation ◽  
Platelet Rich Plasma ◽  
Thromboxane A2 ◽  
Initial Step ◽  
Platelet Activity

Diabetes Mellitus (DM) is a risk factor in the development of vasculopathies and its complications. It produces also its own microangiopathy. Evidence was reported of increased platelet activity in DM in different assays. Platelets aggregation and the arachidonic cycle could play a key role in the increased tendency to thrombosis. A disorder of ratio TXA2/PGI2, two opposing prostaglandin derivatives, could be the initial step. We intended to evaluate a thromboxane like substance (TLS) produced from platelet rich plasma (PRP) and to compare between normals and diabetic retinopathy (DR) patients. TLS was measured in 16 controls and 16 patients. Assay was done with the aggregating activity developed in PRP (considered TLS) after addition of arachidonic acid (f.c. 2 mM). The supernatant of the PRP (100 μl) was taken 40 sec. after the aggregation started and were added to a normal PRP treated with aspirin (f.c. 40 μl/ml) adjusted to 250.000 - 300.000 pl/μl and the degree of platelet aggregation measured in a Chrono Log Aggregometer. TLS was inactivated after its incubation during 2 min. at 37°C. This finding suggests this activity is due to TXA2.The results obtained (expressed in % of platelet aggregation) were: controls x 16.37% ± 6.28 and DR x 36.00% ± 9.72.The increase detected in the DR group supports previous experimental reports suggesting the role of the thromboxane A2 in vaso occlusive complication of diabetes mellitus.

Influence of environmental factors on chronic prostatitis-like symptoms in young men: results of a community-based survey

Urology ◽  
2001 ◽  
Vol 58 (6) ◽  
pp. 853-858 ◽  
Author(s):  
Ja Hyeon Ku ◽  
Min Eui Kim ◽  
Nam Kyu Lee ◽  
Young Ho Park
Keyword(s):  
Environmental Factors ◽  
Chronic Prostatitis ◽  
Young Men ◽  
Community Based

scholarly journals Non-invasive vagus nerve stimulation acutely improves spontaneous cardiac baroreflex sensitivity in healthy young men: A randomized placebo-controlled trial

2017 ◽  
Vol 10 (5) ◽  
pp. 875-881 ◽  
Author(s):  
Diego Antonino ◽  
André L. Teixeira ◽  
Paulo M. Maia-Lopes ◽  
Mayara C. Souza ◽  
Jeann L. Sabino-Carvalho ◽  
...  
Keyword(s):  
Vagus Nerve ◽  
Nerve Stimulation ◽  
Vagus Nerve Stimulation ◽  
Baroreflex Sensitivity ◽  
Controlled Trial ◽  
Young Men ◽  
Non Invasive
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